I am involved in studying the acquired genetic abnormalities leading to human lung and other cancers using global genomic approaches. My projects include a genome wide search for oncogenes and tumor suppressor genes that should provide a comprehensive view of the genetic determinants of lung and other cancers as well as identify putative targets for cancer therapies; identification of gene signatures associated with sensitivity or resistance to common anti-cancer agents with the aim of identifying drugs to which patients will respond favorably; identification of genetic changes leading to tumor transformation in cell lines irradiated with accelerated high energy particles, as a contribution to a NASA study on the effects of cosmic radiation on astronauts. These studies all involve microarrays, a technique that can scan the genome of a test sample for global changes in mRNA expression, or for DNA amplification and deletion (CGH microarrays). Computational methods are a central part of this, many of which are commercially available while others need to be designed or customized according to specific project requirements. Microarray data also creates an important resource that can be queried for individual gene changes for the benefit of multiple other projects and collaborations.
RESEARCH INTERESTS
Lung Cancer
Microarrays
Bioinformatics
SIGNIFICANT PUBLICATIONS
Girard, L., Zochbauer-Muller, S., Virmani, A. K., Gazdar, A. F., and Minna, J. D., "Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering" Cancer Research, 60:4894-4906, 2000
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