Working on how calcium signaling is transducted and/or translated into precise transmitted information to regulate a variety of cellular functions from exocytosis to gene regulation. To control the downstream messengers and effectors, cells generate precisely defined Ca2+ signals, often in the form of propagating Ca2+ waves, or by assembling Ca2+ signaling complexes in cellular microdomains. Electrophysiological, confocal and TIRF imaging techniques are used to monitor Ca2+ in subcellular compartments and to follow the activity of Ca2+ pumps and channels. These approaches are complemented by a variety of molecular techniques to study organization of Ca2+ signaling complexes. Another interest is function and regulation of ion transport in epithelial cells. Current focus is on SLC26A transporters and purinergic receptors.
RESEARCH INTERESTS
Ca2+ signaling and its transduction pathway
Effects and regulation of ion transport in epithelial cells
RECENT PUBLICATIONS
Li Q, Luo X, Muallem S, "Functional mapping of Ca2+ signaling complexes in plasma membrane microdomains of polarized cells." J Biol Chem, 279(27):27837-40, July 2004
Wang YJ, Li WH, Wang J, Xu K, Dong P, Luo X, Yin HL, "Critical role of PIP5KIγ87 in InsP3-mediated Ca2+ signaling." J Cell Biol, 167(6):1005-10, December 2004
Luo X, Shin DM, Wang X, Konieczny SF, Muallem S, "Aberrant localization of intracellular organelles, Ca2+ signaling, and exocytosis in Mist1 null mice." J Biol Chem, 280(13):12668-75, April 2005
Li Q, Luo X, Muallem S, "Regulation of the P2X7 receptor permeability to large molecules by extracellular Cl- and Na+." J Biol Chem, 280(29):26922-7, July 2005
Jennings JJ Jr, Zhu JH, Rbaibi Y, Luo X, Chu CT, Kiselyov K, "Mitochondrial aberrations in mucolipidosis type IV." J Biol Chem, [Epub ahead of print] October 2006
SIGNIFICANT PUBLICATIONS
Luo X, Shin DM, Wang X, Konieczny SF, Muallem S, "Aberrant localization of intracellular organelles, Ca2+ signaling, and exocytosis in Mist1 null mice." J Biol Chem, 280(13):12668-75, April 2005
Shin DM, Dehoff M, Luo X, Kang SH, Tu J, Nayak SK, Ross EM, Worley PF, Muallem S, "Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCβ GAP activities." J Cell Biol, 162(2):293-303, July 2003
Luo X, Popov S, Bera AK, Wilkie TM, Muallem S, "RGS proteins provide biochemical control of agonist-evoked [Ca2+]i oscillations." Mol Cell, 7(3):651-60, March 2001
Luo X, Zheng W, Yan M, Lee MG, Muallem S, "Multiple functional P2X and P2Y receptors in the luminal and basolateral membranes of pancreatic duct cells." Am J Physiol, 277(2 Pt 1):C205-15, August 1999
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