Chemical synthesis of biofunctional natural products
RECENT PUBLICATIONS
Gelin Wang, Libin Shang, Anthony W. G. Burgett, Patrick G. Harran, and Xiaodong Wang, "Diazonamide toxins reveal an unexpected function for ornithine d-amino transferase in mitotic cell division." Proc Natl Acad Sci USA, 104(7):2068-2073, 2007
Noelle S. Williams, Anthony W. G. Burgett, Ashley S. Atkins, Xiaodong Wang, Patrick G. Harran, and Steven L. McKnight, "Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity" Proc Natl Acad Sci USA, 104(7):2074-2079, 2007
Hugo Garrido-Hernandez, Masakazu Nakadai, Mark Vimolrantana, Qingyi Li, Thomas Doundoulakis, Patrick G. Harran, "Spirocycloisomerization of Tethered Alkylidene Glycocyamidines: Synthesis of a Base Template Common to Paulau’amine Family Alkaloids" Angew.Chem Intl. Ed. Engl., 44:765-769, 2005
Lin Li, Ranny Mathew Thomas, Hidetaka Suzuki, Jef K. De Brabander, Xiaodong Wang, Patrick G. Harran, "A Small Molecule Smac Mimic Potentiates TRAIL- and TNFa-Mediated Cell Death." Science, 305:1471-1474, 2004
SIGNIFICANT PUBLICATIONS
Li, J., Jeong, S., Esser, L., and Harran, P.G., "Total Synthesis of Nominal Diazonamides: Part 1. Convergent Preparation of the Structure Proposed for (-)-Diazonamide A." Angew. Chem Intl. Ed. Engl., 40:4765-4770, 2001
Li, J., Burgett, A., Esser, L., Amezcua, C., and Harran, P. G., "Total Synthesis of Nominal Diazonamides: Part 2. On the True Structure and Origin of Natural Isolates." Angew. Chem Intl. Ed. Engl., 40:4770-4773, 2001
Anthony W. G. Burgett, Qingyi Li, Qi Wei, and Patrick G. Harran, "A Concise and Flexible Total Synthesis of (-)-Diazonamide A" Angew. Chem. Intl. Ed. Engl, 42:4961-4966, 2003
Iryna Zubovych, Thomas Doundoulakis, Patrick G. Harran and Michael G. Roth, "A missense mutation in Caenorhabditis elegans prohibitin 2 confers an atypical multidrug resistance" Proc Natl Acad Sci USA, 103(42):15523-15528, 2006
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