Dr. Euhus’ primary research interests are in the areas of cancer genetics, breast cancer risk assessment and breast cancer prevention. In collaboration with the BayesMendel Group at Johns Hopkins University, he continues to develop his CancerGene program, a software suite for cancer risk assessment and counseling with a special focus on inherited cancer syndromes. His laboratory is actively engaged in identifying markers in breast tissue that could be used to identify women at high risk for breast cancer or that could be used as surrogate endpoints in prevention trials. Most recently his work has focused on DNA methylation, a chemical change in DNA that inappropriately turns off important tumor suppressor genes. These changes are being evaluated in breast cells obtained from high risk women by nipple duct lavage or fine needle aspiration biopsy. Markers of proliferation, programmed cell death and gene expression are also being evaluated as part of a multi-institutional National Cancer Institute-funded chemoprevention trial for which he serves as the principal investigator. His research group is currently exploring mammographic density as a potential marker of breast cancer risk and a potential surrogate endpoint for prevention trials. The ultimate goal of the research program is to discover ways to prevent breast cancer in women who are at high risk for the disease.
RESEARCH INTERESTS
Mathematical Models in Breast Cancer Risk Assessment
Cancer Genetics
Molecular Biology of Breast Preneoplasia
RECENT PUBLICATIONS
Euhus D, Bu D, Ashfaq R, Xie X, Bian A, Leitch M, Lewis C., "Atypia and DNA Methylation in Nipple Duct Lavage in Relation to Predicted Breast Cancer Risk" Cancer Epidemiol Biomark Prev, 16:in press, September 2007
Bushnaq Z, Ashfaq R, Leitch AM, Euhus D, "Patient Variables That Predict Atypical Cytology by Nipple Duct Lavage" Cancer, 109:1247-1254, April 2007
Bu D, Tomlinson G, Lewis CM, Zhang C, Kildebeck E, Euhus DM., "An Intronic Polymorphism Associated with Increased XRCC1 Expression, Reduced Apoptosis and Familial Breast Cancer." Breast Cancer Res Treat, 99:257-265, October 2006
Lewis C, Herbert B-S, Bu D, Halloway S, Beck A, Shadeo A, Zhang C, Ashfaq R, Shay JW, Euhus DM, "Telomerase immortalization of human mammary epithelial cells derived from a BRCA2 mutation carrier." Breast Cancer Res Treat, 99:103-115, September 2006
Chen S, Iversen ES, Friebel T, Finkelstein, Weber B, Eisen A, Peterson L, Schildkraut JM, Isaacs C, Peshkin BN, Corio C, Leondaridis L, Tomlinson G, Dutson D, Kerber R, Amos CI, Strong LC, Berry DA, Euhus DM, Parmigiani G., "Characterization of BRCA1 and BRCA2 Mutations in a Large US Sample." J Clin Oncol, 24:863-71, February 2006
SIGNIFICANT PUBLICATIONS
Euhus DM, Smith KC, Robinson L, Stukey FA, Olopade O, Cummings S, Garber JE, Chittenden A, Mills GB, Reiger P, Esserman L, Crawford B, Hughes KS, Roche C, Ganz P, Sheldon J, Fabian CJ, Klemp J, Tomlinson G., "Pretest Prediction of BRCA1 or BRCA2 Mutation by Risk Counselors and the Computer Model BRCAPRO." Journal of the National Cancer Institute, Vol. 94 No. 11:844-851, June 2002
Euhus DM, Cler L, Sivapurkar N, Milchgrub S, Peters GN, Leitch AM, Heda S, Gazdar AF., "Loss of Heterozygosity in Benign Breast Epithelium in Relation to Breast Cancer Risk." Journal of National Cancer Institute, Vol. 94 No. 11:858-860, June 2002
Shames DS, Girard L, Gao B, Sato M, Jian A Shyr Y, Fong K, Gerald W, Pollack JR, Perou CM, Gazdar AF, Euhus DM, Shay JS, Minna JD., "A Genome-wide Screen for Methylation in Lung Cancer Identifies Novel Methylation Markers for Multiple Malignancies" PLoS Medicine, 3:e486, December 2006
Chen S, Wang W, Lee S, Nafa K, Lee J, Romans K, Watson P, Gruber S, Euhus DM, Kinzler K, Jass J, Gallinger S, Lindor N, Casey G, Ellis N, Giardiello F, Offit K, Parmigiani G., "Prediction of Germline Mutations and Cancer Risk in the Lynch Syndrome." JAMA, 296:1479-1487, September 2006
Lewis C, Cler L, Bu D, Zochbauer-Muller S, Milchgrub S, Naftalis E, Leitch AM, Minna J, Euhus DM., "Promoter Hypermethylation in Benign Breast Epithelium in Relation to Predicted Breast Cancer Risk." Clin Cancer Res, 11:166-72, January 2005
Point and right click (click and hold for Mac users) your mouse onand select "Save this link (or target) as..." option to save the file to your local computer.
