My laboratory is primarily focused on research relating to how specific receptors regulate lymphocyte function. Our current efforts are aimed at receptors common to both the innate and adaptive immune response. We are interested in defining how these receptors transmit signals to natural killer cells and T and B lymphocytes to regulate their behavior with regards to infection, tumors and autoimmunity. We are especially focused on the molecular mechanisms whereby these lymphocytes integrate the various signals generated by the engagement of these receptors and we wish to define methods to manipulate these events to allow us to modify immune responses in vivo. Our current studies have focused on a family of receptors (the SLAM family) that are involved in fatal lymphoproliferative disorders and the autoimmune disorder lupus.
RESEARCH INTERESTS
Natural killer cells
cytotoxic mechanisms
immune regulation
cancer immunotherapy
autioimmunity
RECENT PUBLICATIONS
Lee, KM, Forman, JP, McNerney, ME, Stepp, S, Kuppireddi, S, Guzior, D, Latchman, YE, Sayegh MH, Yagita, H, Park, CK, Oh SB, Wulfing, C, Schatzle J, Mathew PA, Sharpe AH, Kumar V., "Requirement of homotypic NK cell interactions through CD48/2B4 in the generation of NK effector functions" Blood, 107(8):3181-3188, Spring 2006
Calpe S, Erdos E, Liao G, Wang N, Rietdijk S, Simarro-Grande M, Scholtz B, Mooney J, Lee C, Shin M, Rajnavolgyi E, Schatzle J, Morse H, Terhorst C, Lanyi A., "Identification and Characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2 domain adaptors" Immunogenetics, Jan:1-11, January 2006
Kumar KR, Li L, Yan M, Bhaskarabhatla M, Mobley AB, Nguyen C, Mooney JM, Schatzle JD, Wakeland EK and Mohan C, "Regulation of B cell tolerance by the lupus susceptibility gene Ly108" Science, 312(5780):1665-1669, Summer 2006
Chan AY, Westcott JM, Mooney JM, Wakeland EK and Schatzle JD, "The role of SAP and the SLAM family in autoimmunity" Curr. Opin. Immunol., 18 Winter 2006
Johannson MH, Taylor MA, Jagodic M, Tus K, Schatzle JD, Wakeland EK and Bennett M., "Mapping of quantitative trait loci determining NK cell-mediated resistance to MHC class I-deficient bone marrow grafts in perforin-deficient mice." J. Immunology, 177(11):7923-7929, December 2006
SIGNIFICANT PUBLICATIONS
Williams NS, Moore TA, Schatzle JD, Puzanov IJ, Sivakumar PV, Zlotnik A, Bennett M, Kumar V., "Generation of lytic natural killer 1.1+, Ly-49- cells from multipotential murine bone marrow" Journal of Experimental Medicine, 186(9):1609-1614, November 1997
Schatzle JD, Sheu S, Stepp SE, Mathew PA, Bennett M, Kumar V., "Characterization of inhibitory and stimulatory forms of the murine natural killer cell" Proc Natl Acad Sci U S A, 96(7):3870-3875, March 1999
Sayos J, Nguyen KB, Wu C, Stepp SE, Howie D, Schatzle JD, Kumar V, Biron CA, Terhorst C., "Potential pathways for regulation of NK and T cell responses: differential X-linked" International Immunology, 12(12):1749-1757, December 2000
Wulfing C, Tskvitaria-Fuller, I, Burruoghs, N, Sjaastad, MD, Klem, J, and Schatzle JD., "Interface accumulation of receptor/ligand couples in lymphocyte activation: methods, mechanisms, and significance." Immunol. Rev., 189:64-83, 2002
Wulfing, C., Klem, J., Purtic, B. and Schatzle J.D., "Distinguishing cytoskeletal polarization in innate and adaptive cytolytic killing." PNAS, 100(13):7767-72, 2003
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