Validation of myocardial triglyceride in vivo in respect to: obesity, ethnicity, gender, and diabetes. The aim of this project is to determine the role of triglyceride deposits within myocardial cells with a focus on the development of cardiac spectroscopy to evaluate relationship between triglyceride content within cardiac muscle and myocardial function.
Response of myocardial triglyceride to pharmacological interventions or life style changes.
In vivo metabolism of hepatic triglyceride.
RESEARCH INTERESTS
Development of noninvasive, spectroscopic tests for ectopic triglyceride with applications to myocardium skeletal muscle and liver.
Research in the field of prevention of diabetes and heart failure.
RECENT PUBLICATIONS
Szczepaniak LS, Babcock EE, Schick F, Dobbins RL, Garg A, Burns DK, McGarry JD, Stein DT., "Measurement of intracellular triglyceride stores by H1 spectroscopy: validation in vivo." Am J Physiol, 276(5 Pt 1):E977-89, May 1999
Szczepaniak LS, Dobbins RL, Stein DT, McGarry JD, "Bulk magnetic susceptibility effects on the assessment of intra- and extra-myocellular lipids in vivo." Magn Reson Med, 47(3)::607-10, March 2002
Nurenberg P, Sartoni-D’Ambrosia G, Szczepaniak LS, "Magnetic resonance spectroscopy of renal and other retroperitoneal tumors." Curr Opin Urol, 12(5)::375-80, September 2002
Szczepaniak LS, Dobbins RL, Metzger GJ, Sartoni-D’Ambrosia G, Arbique D, Vongpatanasin W, Unger R, Victor RG, "Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imaging" Magn Reson Med, 49(3):417-23, March 2003
Simha V, Szczepaniak LS, Wagner AJ, DePaoli AM, Garg A, "Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy" Diabetes Care, 26(1):30-5, January 2003
SIGNIFICANT PUBLICATIONS
Dobbins RL, Szczepaniak LS, Zhang W, McGarry JD, "Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion" Am J Physiol Endocrinol Metab, 284(4):E778-87, April 2003
LS Szczepaniak, EE Babcock, AD Sherry, C Malloy, "Oxidation of acetate in rabbit skeletal muscle: detection by 13C NMR spectroscopy in vivo" Magn Reson Med, 36:451, 1996
LS Szczepaniak, A Sargeson, M Tweedle, RG Bryant, "Nuclear Magnetic Spin-Relaxation of Water Protons Caused by Metal Cage Compounds" Bioconjugate Chemistry, 3:27, 1992
LS Szczepaniak, RG Bryant, "Proton Nuclear Relaxation in Aqueous Copper(II) Amine Chelate Solutions" Inorganica Chimica Acta, 184:7, 1991
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