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Alan Varley

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Alan Varley, Ph.D.

Details of Research

Alan Varley

Name:		Alan Varley, Ph.D.
Academic Title:		Assistant Professor
Primary Appointment:		Internal Medicine - Infectious Diseases
Affiliations:		Internal Medicine
Department Website:		Infectious Diseases
Lab Website:		Molecular Host Defense Laboratory

RESEARCH INTERESTS

	Application of Physiologically-regulated Gene Therapy to Inflammatory Diseases

RECENT PUBLICATIONS

	Miagkov AV, Varley AW, Munford RS, Makarov SS, "Endogenous Regulation of a Therapeutic Transgene Restores Homeostasis in Arthritic Joints" Journal of Clinical Investigation, 109 (9):1223-1229, May 2002
	Cowan J, Sinton CM, Varley AW, Wians FH, Haley RW, Munford RS, "Gene Therapy to Prevent Organophosphate Intoxication" Toxicology and Applied Pharmacology, 173 (1):1-6, May 2001
	Bakker, AC, van de Loo FAJ, Joosten LAB, Arntz OJ, Varley AW, Munford RS, van den Berg WB, "C3-Tat/HIV-Regulated Intraarticular Human Interleukin-1 Receptor Antagonist Gene Therapy Results in Efficient Inhibition of Collagen-Induced Arthritis Superior to Cytomegalovirus-Regulated Expression of the Same Transgene" Arthritis and Rheumatism, 46 (6):1661-1670, June 2002
	Varley AW, Munford RS, "Physiologically Responsive Gene Therapy" Molecular Medicine Today, 4 (10):445-451, October 1998

SIGNIFICANT PUBLICATIONS

	Varley AW, Geiszler SM, Gaynor RB, Munford RS, "A Two-Component Expression System that Responds to Inflammatory Stimuli in Vivo" Nature Biotechnology, 15 (10):1002-1006, October 1997
	Varley AW, Coulthard MG, Meidell RS, Gerard RD, Munford RS, "Inflammation-Induced Recombinant Protein Expression in Vivo using Promoters from Acute-Phase Protein Genes" Proceedings of the National Academy of Sciences of the United States of America, 92 (12):5346-5350, June 1995
	Department of Microbiology, "Cell Division Genes of Bacillus subtilis: The minicell locus (divIVB) encodes septum placement (min) and cell shape determinants (mre)" The University of Texas Southwestern Medical Center, 1993
	Seminar, Microbiology Seminar Series, "Cloning and Molecular Analysis of the divIVB Locus of B.subtilis" USC School of Medicine, 1992

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