My scientific interests have focused on understanding the regulatory role of T helper (Th) cells and the cytokines that they secrete. Murine CD4+ Th cell clones can be divided into two distinct groups, defined by their patterns of cytokine secretion. In response to stimulation, Th1 clones secrete IL-2, IFN-gamma and lymphotoxin, whereas Th2 clones secrete IL-4, IL-5, IL-6, IL-10 and IL-13. Cells with these two different cytokine patterns have very different functional capabilities. Th2 cells are most effective at providing B cell help, whereas Th1 cells are able to mediate delayed-type hypersensitivity reactions and activate macrophages. Th1 and Th2 subsets, both in mouse and human, have been implicated in susceptibility and resistance to a wide spectrum of diseases and autoimmune disorders. Recent characterization of CD8+ (Tc1 and Tc2), NK cell (NK1 and NK2) and gamma/delta T cell (Tgamma/delta 1 and T gamma/delta 2) subsets have led to the conclusion that the immune system, in response to any particular antigen, can mount either a Type 1 or a Type 2 immune response. Understanding the mechanisms responsible for this decision have far-reaching implications for immunotherapy.
RESEARCH INTERESTS
T helper cell subsets
Immune regulation of disease
RECENT PUBLICATIONS
JD Farrar, KH Katz, JL Windsor, G Thrush, RH Scheueymann, JW Uhr and NE Street, "Cancer dormancy VII: A regulatory role for CD8+ T cells and IFN-gamma in establiching and maintaining the dormant state." Journal of Immunology, 162:2842, 1999
KA Hoag, MF Lipscomb, AA Izzo, and NE Street, "IL-12 and IFN-gamma are required for initiating the protective Th1 response to pulmonary cryptococcosis in resistant C.B-17 mice" American Journal of Respiratory Cell and Molecular Biology, 17:733, 1997
VM sanders, BA Fuchs, and NS Street, "Differential expression of the beta-2-adrenergic receptor by Th1 and Th2 clones: Implications for cytokine production and B cell help" Journal of Immunology, 158:4200, 1997
SIGNIFICANT PUBLICATIONS
NE Street, JH Schumacher, TAT Fong, H Bass, DF Fiorentino, JA Leverah and TR Mosmann, "Heterogeneity of mouse helper T cells: Evidence from bulk culture and limiting dilution cloning for precursors of Th1 and Th2 cells" Journal of Immunology, 144:1629, 1990
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