Our group performs research on the genetics of the Human Leukocyte Antigens (HLA), their distribution in different ethnic groups and the description and nucleotide sequencing of novel alleles found in isolated populations. We also study the MICA and MICB antigens encoded in the human Major Histocompatibility Complex (MHC). These recently described molecules are of interest because of their polymorphism and predominant expression in endothelial cells, monocytes, fibroblasts and epithelial cells including keratinocytes. The possible role of MICA antigens in predisposition to certain diseases and their capacity to induce the production of alloantibodies and possibly serve as targets for graft rejection are being investigated.
RESEARCH INTERESTS
Major and Minor Histocompatibility Antigens
Autoimmunity and histocompatibility antigens
Molecular methods for histocompatibility testing
Anthropological studies of HLA antigens
Immunology of allograft rejection
RECENT PUBLICATIONS
Zou Y, Bresnahan W, Taylor RT, Stastny P, "Effect of human cytomegalovirus on expression of MHC class I-related chains A." Journal of Immunology, 174:3098, 2005
Zou Y, Heinemann FM, Grosse-Wilde H, Sireci G, Wang Z, Lavingia B, Stastny P, "Detection of anti-MICA antibodies in patients awaiting kidney transplantation, during the post-transplant course and in eluates from rejected kidney allografts by Luminex flow cytometry." Human Immunology, 67:230, 2006
Stastny P, "Introduction: MICA/MICB in innate immunity, adaptive immunity, autoimmunity, cancer and in the immune response to transplants." Human Immunology, 67:141, 2006
Zhang Y, Stastny P, "MICA antigens stimulate T cell proliferation and cell-mediated cytotoxicity." Human Immunology, 67:215, 2006
Han M, Fallena M, Guo Y, Stastny P, "Natural killer cell crossmatch functional analysis of inhibitory killer immunoglobulin-like receptors (KIR) and their HLA ligands." Human Immunology, 68:507, 2007
SIGNIFICANT PUBLICATIONS
Stastny P, Stembridge VA, Ziff M, "Homologous disease in the adult rat, a model for human autoimmune disease." Journal of Experimental Medicine, 118:635, 1963
Stastny P, "Association of the B-cell alloantigen DRw4 with rheumatoid arthritis." New England Journal of Medicine, 298:449, 1977
Feighery C, Stastny P, "HLA-D region-associated determinants serve as targets for human cell-mediated lysis." Journal of Experimental Medicine, 149:485, 1979
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