The genetic and vascular risk disease causes of Alzheimer’s disease are my main areas of clinical basic science research. Families with Alzheimer’s disease and patients with diabetes, hypertension, hypercholesterolemia and cerebrovascular disease are of interest to our research group. The immunoptherapy of treating Alzheimer’s disease is the area of my laboratory research directed at implementing a clinical trial with a DNA gene vaccine for Abeta42 to develop anti-Abeta42 antibodies which will reduce the Abeta42 (amyloid) levels in the brain of Alzheimer’s disease patients.
RESEARCH INTERESTS
Alzheime's Disease
Neurogenerative Disorders
Clinical and Molecular Neurogenetics
RECENT PUBLICATIONS
Rosenberg RN, "Genomic Neurology" Archives of Neurology, 58:1739-1741, 2001
Rosenberg RN, "Genomics and the Transformation of Neurology" JAMA, 286:2869-2870, 2001
Rosenberg RN, "Mitochondrial Therapy for Parkinson Disease" Archives of Neurology, 59:1523, 2002
Qu B-X, Boyer PJ, Johnston SA, Hynan LS, Rosenberg RN, "Abeta42 gene vaccination reduces brain amyloid plaque burden in transgenic mice" J. Neurol. Sci., 244:151-158, May 2006
Tang K, Hynan LS, Baskin F, and Rosenberg RN, "Platelet amyloid precursor protein processing: a bio-marker for Alzheimer disease" J. Neurol. Sci., 240:53-58, Fall 2006
SIGNIFICANT PUBLICATIONS
Rosenberg RN, Richter RW, Risser RC, et al., "Genetic Factors for the Development of Alzheimer's Disease in the Cherokee Indian" Archives of Neurology, 53:997-1000, 1996
Rosenberg RN, "Evolutionary Time and Human Memory" JAMA, 288:3045-3047, 2002
Rosenberg RN, Baskin F, Fosmire J, Risser R, et al., "Altered Amyloid Protein Processing in Alzheimer's Disease Patient Platelets" Archives of Neurology, 54:139-144, 1997
Qu B-X, Boyer PJ, Johnston SA, Hynan, LS, Rosenberg RN, "Abeta42 gene vaccination reduces brain amyloid plaque burden in transgenic mice" J. Neurol. Sci., 244:151-158, May 2006
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