Dr. Roehrborn is involved in all aspects of basic, translational and clinical research in benign prostatic hyperplasia (BPH) and prostate cancer. He has conducted numerous trials in the areas of medical management, minimally invasive and surgical treatment for lower urinary tract symptoms and BPH as well as prostate cancer. His clinical activities also involve research in various aspects of prostate cancer, tumor marker research and outcomes from urological interventions.
RESEARCH INTERESTS
Prostate cancer
Benign prostatic hyperplasia
Tumor markers
Outcomes research
Urological Ultrasound
RECENT PUBLICATIONS
Serfling R, Shulman M, Thompson GL, Xiao Z, Benaim E, Roehrborn CG, Rittmaster R, "Quantifying the impact of prostate volumes, number of biopsy cores and 5alpha-reductase inhibitor therapy on the probability of prostate cancer detection using mathematical modeling" J Urol, 177:2352-2356, 2007
Leonard S. Marks, Claus G. Roehrborn, Eric Wolford and Timothy Wilson, "The effect of dutasteride on the peripheral and transition zones of the prostate and the value of the transition zone index in predicting treatment response" Journal of Urology, 177(4):1408-1413, 2007
Chun FK, Briganti A, Salonia A, Rigatti P, Saad F, Huland H, Montorsi F, Graefen M, Karakiewicz PI, "Prostate-specific antigen improves the ability of clinical stage and biopsy gleason sum to predict the pathologic stage at radical prostatectomy in the new millenium" European Urology, 2007
Karam JA, Lotan Y, Roehborn CG, Ashfaq R, Karakiewicz PI, Shariat SF, "Caveolin-1 overexpression is associated with aggressive prostate cancer recurrence" Prostate, 67:614-622, 2007
Stephenson AJ, Scardino PT, Kattan MW, Pisansky TM, Slawin KM, Klein EA, Anscher MS, Michalski JM, Sandler HM, Lin DW, Forman JD, Zelefsky MJ, Kestin LL, Roehrborn CG, Catton CN, DeWeese TL, Liauw SL, Valicenti RK, Kuban DA, Pollack A, "Predicting the outcome of salvage radiation therapy for recurrent prostate cancer after radical prostatectomy" J Clin Oncol, 25:2035-2041, 2007
SIGNIFICANT PUBLICATIONS
John D. McConnell, Claus G. Roehrborn, Oliver M. Bautista, Gerald L. Andriole, Jr., et al, "The long-term effect of doxazosin finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia" New England Journal of Medicine, 349:2387-2389, 2003
Andrew J. Stephenson, Shahrokh F. Shariat, Michael J. Zelefsky, Michael W. Kattan, E. Brian Butler, Bin S. Teh, Eric A. Klein, Patrick A. Kupelian, Claus G. Roehrborn, David A. Pistenmaa, Heather D. Pacholke, Stanley L. Liauw, Matthew S. Katz, Steven Leibel, Peter T. Scardino and Kevin M. Slawin, "Salvage radiotherapy for recurrent prostate cancer after radical prostatectomy" American Medical Association (Reprinted JAMA), 1325-1332, 2004
Kaplan SA, Roehrborn CG, Rovner EDs, Carlsson M, Bavendam T, Guan Z, "Tolterodine and tamsulosin for treatment of men with lower urinary tract symtpoms and overactive bladder, a randomized controlled trial" JAMA, 296(19):2319-2328, 2006
D’Amico AV, Roehrborn CG, "Effect of 1 mg/day finasteride on concentrations of serum prostate-specific antigen in men with androgenic alopecia: a randomised controlled trial" Lancet Oncol, 8:21-25, 2007
Jose A. Karam, Yair Lotan, Pierre I. Karakiewicz, Raheela Ashfaq, Arthur I. Sagalowsky, Claus G. Roehrborn, Shahrokh F. Shariat, "Use of combined apoptosis biomarkers for prediction of bladder cancer recurrence and mortality after radical syctectomy" The Lancet, 8:128-136, 2007
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