My research interests lay in the area of anatomy and physiology of the peripheral ear (temporal bone). My lab is involved in investigations into the effects of otologic agents and other types of interventions for treatment of temporal bone diseases. We are also working with various otic agents and biomedical engineering technologies to determine the benefits/risks these treatments create in temporal bone applications. For instance, we are investigating the formation of biofilms on implant materials, in particular, cochlear implants and in tissues of the head and neck. Our goal is to develop a means to reduce their occurrence. We are currently investigating the cellular and molecular mechanisms involved in hearing loss due to mutation in the gene that causes Usher’s syndrome type 1F, the gene that produces Protocadherin 15.
RESEARCH INTERESTS
Cellular mechanisms involved in sensory neural hearing loss
Investigations of biomedical engineering technologies applied to the temporal bone and auditory system
Role of biofilms in chronic recurrent infections of the temporal bone
RECENT PUBLICATIONS
Pawlowski KS, Kikkawa YS, Wright CG, Alagramam KN, "Progression of inner ear pathology in Ames waltzer mice and the role of protocadherin 15 in hair cell development" Journal of the Association for Research in Otolaryngology, 7(1):in press, 2006
Pawlowski KS, Wawro D, Roland PS, "Bacterial Biofilm Formation on a Human Cochlear Implant" Otology and Neurotology, 26:972-975, 2005
Alagramam KN, Stahl JS, Jones SM, Pawlowski KS, Wright CG, "Characterization of vestibular dysfunction in the mouse model for Usher syndrome 1F" Journal of the Association for Research in Otolaryngology, 6(2):106-118, 2005
Pawlowski KS, "Anatomy and Physiology of the Cochlea" Ototoxicity, 2004
Zheng QY, Yu H, Washington JL III, Kisly LB, Kikkawa YS, Pawlowski KS, Wright CG, Alagramam KN, "A new spontaneous mutation in the mouse protocadherin 15 gene" Hearing Research, 1-2/219:110-20, 2006
SIGNIFICANT PUBLICATIONS
Alagramam KN, Murcia CL, Kwon HY, Pawlowski KS, Wright CG, and Woychik RP, "The mouse Ames Waltzer gene encodes a protocadherin required for the normal development of inner ear neuroepithelial cells" Nature Genetics, 27(1):99-102, 2001
Wright CG, Pawlowski KS, Roland PS, and Meyerhoff WL, "An animal model for external ear canal inflammation" Laryngoscope; (Also presented at the Southern Section of the American Laryngological, Rhinological, and Otological Society Meeting, St. Petersburg Beach, Fla. Jan. 2000.), 110(7):1112-1118, 2000
Pawlowski KS, Wright CG, Meyerhoff WL, "Histologic demonstration of glycosaminoglycans in inner ear fluids" Acta Otolaryngologica (Stockholm), 118/4:505-510, 1998
Badr-El-Dine M, Gerken GM, Wright CG, Robinson KS, Meyerhoff WL, "Electrocochleographic evaluation of the guinea pig model of endolymphatic hydrops" Annals of Otology Rhinology and Laryngology, 106/11:934-942, 1997
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