Our long-term goals are to elucidate the transcriptional regulatory mechanisms of genes involved in vascular diseases and to characterize the signaling pathways coupling these transcriptional programs to the extracellular signals that trigger these diseases. There are three projects that are currently being pursued in the lab.
(1) To characterize the molecular mechanism by which a forkhead transcription factor FOXO4 regulates matrix metalloproteinase and smooth muscle gene expression and phenotypes of smooth muscle cells.
(2) To characterize the molecular mechanism of FOXO4 in regulation of inflammatory gene expression and its role in inflammatory bowel disease and atherosclerosis.
(3) To characterize the signaling pathways that regulate FOXO4 activities in epithelial cells, macrophages, and vascular smooth muscle cells.
RESEARCH INTERESTS
Molecular mechanism of cardiovascular diseases
Vascular biology
Intracellular signaling
Transcriptional regulation
RECENT PUBLICATIONS
Li H, Liang J, Castrillon DH, DePinho RA, Olson EN, Liu Z-P, "Foxo4 regulates TNFa-directed smooth muscle cell migration by activating matrix metalloproteinase 9 gene transcription" Molecular and Cellular Biology, 27:2676-2686, 2007
Liu, ZP, Wang, Z, Yanagisawa, H, Olson, EN, "Phenotypic Modulation of Smooth Muscle Cells through Interaction of Foxo4 and Myocardin" Developmental Cell, 9:161-270, 2005
Shin*, CH, Liu*, ZP, Passier*, R, Zhang, CL, Wang, DZ, Harris, TM, Yamagishi, H, Richardson, JA, Childs, G, Olson, EN, "Modulation of cardiac growth and development by HOP, an unusual homeodomain protein" Cell, 110:725-35, 2002
Liu, ZP, Olson, EN., "Suppression of proliferation and cardiomyocyte hypertrophy by CHAMP, a cardiac-specific RNA helicase" Proc Natl Acad Sci USA, 99:2043-2048, 2002
Liu, ZP, Nakagawa, O, Nakagawa, M, Yanagisawa, H, Passier, R, Richardson, JA, Srivastava, D, Olson, EN, "CHAMP, a novel cardiac-specific helicase regulated by MEF2C" Dev Biol., 234:497-509, 2001
SIGNIFICANT PUBLICATIONS
Liu, ZP, Wang, Z, Yanagisawa, H, Olson, EN, "Phenotypic Modulation of Smooth Muscle Cells through Interaction of Foxo4 and Myocardin" Developmental Cell, 9:161-270, 2002
Shin*, CH, Liu*, ZP, Passier*, R, Zhang, CL, Wang, DZ, Harris, TM, Yamagishi, H, Richardson, JA, Childs, G, Olson, EN, "Modulation of cardiac growth and development by HOP, an unusual homeodomain protein" Cell, 110:725-735, 2002
Liu, ZP, Nakagawa, O, Nakagawa, M, Yanagisawa, H, Passier, R, Richardson, JA, Srivastava, D, Olson, EN, "CHAMP, a novel cardiac-specific helicase regulated by MEF2C" Dev Biol., 234:497-509, 2001
Liu, ZP, Galindo, RL, Wasserman, SA, "A role for CKII phosphorylation of the cactus PEST domain in dorsoventral patterning of the Drosophila embryo" Genes Dev., 11:3413-3422, 1997
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