For most new imaging modalities, the idea of a general reconstruction algorithm as found with classical computed tomography (CT) is often not feasible. There are fundamental mathematical difficulties with relating the measured data to the parameters of interests. If, however, some refinement of the imaging task can be performed, then it may be possible to restore the feasibility of the approach. My research involves the development of specific imaging methods that address specific questions of biological relevance. There methods include: detection and characterization of breast microcalcification morphology, application of advanced algorithms for the inverse source problem to the task of measuring tumor volume, and the measurement of elasticity in anisotropic bone using reflected and transmitted waves. This multi-disciplinary approach includes methods from physics, applied mathematics, signal processing, and statistical decision theory.
RESEARCH INTERESTS
acoustic inverse scattering for breast sonography
task-based inverse methods
ultrasonic assessment the bone elasticity tensor
microSPECT and bioluminescent tomography
biomedical compressive sensing and sparsity
RECENT PUBLICATIONS
Soesbe TC, Lewis MA, Richer E, Slavine NV, Antich PP, "Development and Evaluation of an EMCCD based Gamma Camera for Preclinical SPECT Imaging" IEEE Trans Nuc Sci, 54(5):1516-1524, October 2007
NV Slavine, MA Lewis, E Richer, PP Antich, "Iterative reconstruction method for light emitting sources based on the diffusion equation" Medical Physics, 33(1):61-68, 2006
Lewis MA, Arbique G, Richer E, Slavine N, Jennewein M, Constantinescu A, Brekken R, Guild J, Tsyganov EN, Mason RP, Antich PP, "Projection and pinhole based data acquisition for small animal SPECT using storage phosphor technology" Small-Animal SPECT Imaging (Springer), Chapter 24, 2005
Durkee JW, Antich PP, Lewis MA, Parkey, RW, "A Fully Coupled Binary Biochemical Reactive-diffusion Model with Analytic Solution." Journal of Theoretical Biology, 221:163-191, March 2003
Richer E, Lewis MA, Smith B, Li X, Seliounine S, Mason RP, Antich PP, "Comparison of CsI(Tl) and Scintillating Plastic in a Multi-Pinhole/CCD-based Gamma Camera for Small Animal Low Energy SPECT" Small-Animal SPECT Imaging (Springer), Chapter 11, 2005
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