This laboratory has changed its primary focus over the last several years. In the past, we focused on important clinical issues in drug hypersensitivity. However, now our primary research efforts are related to pediatric asthma. We have recently completed a large multi-center NIH-funded study that evaluated the relationship between indoor allergens and pollutants and asthma-associated morbidity in inner city children with asthma. We now are involved in another multi-center NIH-funded inner city pediatric asthma study that is evaluating the effectiveness of various immunomodulatory interventions in children with asthma. In addition to the clinical projects, our group is carrying out mechanistic studies that will attempt to dissect the mechanisms responsible for the clinical effects of the immunomodulatory agents.
RESEARCH INTERESTS
Pediatric Asthma Clinical Research
RECENT PUBLICATIONS
Szefler AJ, Mitchell H, Sorkness CA, Gergen PJ, O’Connor GT, Morgan WJ, Kattan M, Pongracic JA, Teach SA, Bloomberg GR, Eggleston PA, Gruchalla RS, Kercsmar CM, Liu AH, Wildfire JJ, Curry MD, Busse WW, "Management of asthma based on exhaled nitric oxide in addition to guidelines-based treatment for inner-city adolescents and young adults: a randomized controlled trial" Lancet, 372 (9643):1065-72, 2008
Gruchalla RS, Pongracic J, Plaut M, Evans R, Visness CM, Walter M, Crain EF, Kattan M, Morgan WJ, Steinback S, Stout J, Malindzak G, Smartt E, Mitchell H, "The Inner City Asthma Study: Relationships between sensitivity, exposure and morbidity" Journal of Allergy and Clinical Immunology, 115:584-91, March 2005
Morgan WJ, Crain E, Gruchalla RS, O’Connor G, Kattan M, Evans R, Stout J, Malindzak G, Smartt E, Plaut M, Walter M, Vaughn B, Mitchell H, "The Inner City Asthma Study: A home-based environmental intervention in inner city children with asthma" N England Journal of Medicine, 351:1068-80, August 2004
Crain EF, Walter, M, O’Conner GT, Mitchell H, Gruchalla RS, Kattan M, Malindzak GS, Enright P, Evans R 3rd, Morgan W, Stout JW, "Home and allergic characteristics of children with asthma in seven US urban communities and design of an environmental intervention: the Inner-City Asthma Study" Environ Health Perspect, 9/110:939-945, September 2002
Gruchalla RS, "Drug metabolism, danger signals and drug hypersensitivity" J Allergy Clin Immunol, 108:475-478, 2001
SIGNIFICANT PUBLICATIONS
Szefler SJ, Mitchell H, Sorkness CA, Gergen PJ, O’Connor GT, Morgan WJ, Kattan M, Pongracic JA, Teach SA, Bloomberg GR, Eggleston PA, Gruchalla RS, Kercsmar CM, Liu AH, Wildfire JJ, Curry MD, Busse WW, "Management of asthma based on exhaled nitric oxide in addition to guidelines-based treatment for inner-city adolescents and young adults: a randomized controlled trial" Lancet, 372 (9643):1065-72, 2008
Gruchalla RS, Pongracic J, Plaut M, Evans R, Visness CM, Walter M, Crain EF, Kattan M, Morgan WJ, Steinback S, Stout J, Malindzak G, Smartt E, Mitchell H, "The Inner City Asthma Study: Relationships between sensitivity, exposure and morbidity" Journal of Allergy and Clinical Immunology, 115:584-91, March 2005
Daulat S, Solensky R, Earl HS, Casey W, Gruchalla, "Safety of cephalosporin administration to patients with histories of penicillin allergy" J Allergy Clin Immunol, 6/113:1220-1222, June 2004
Gruchalla RS, "Clinical evaluation of drug-induced disease" Lancet, 356:1505-1511, 2000
Solensky R, Earl HS, Gruchalla RS., "Lack of penicillin resensitization in patients with a history of penicillin allergy" Archives of Internal Medicine, 162:822-826, 2002
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