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Elliot Frohman

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Elliot Frohman, M.D., Ph.D.

Details of Research

Name:		Elliot Frohman, M.D., Ph.D.
Endowed Title:		Kenney Marie Dixon-Pickens Distinguished Professorship in Multiple Sclerosis Research Irene Wadel and Robert I. Atha, Jr., Distinguished Chair in Neurology, in Honor of Elliot Frohman, M.D., Ph.D.
Academic Title:		Professor
Primary Appointment:		Neurology
Secondary Appointment:		Ophthalmology
Department Website:		Department of Neurology
Physician Profile:		Elliot Frohman, M.D., Ph.D.

RESEARCH OVERVIEW

	Dr. Frohman’s research is focused on the development of ophthalmological models from which to characterize the processes of neurodegeneration, neuroprotection, and neurorestoration in multiple sclerosis (MS). These studies utilize advanced retinal imaging techniques such as optical coherence tomography (OCT) and laser polarimetry (GDx) and non-conventional MRI techniques such as diffusion tensor and magnetization transfer imaging. Neuroprotection clinical trials aimed at demonstrating preservation of neurons and axons within the retina after acute optic neuritis in MS patients are currently underway.

RESEARCH INTERESTS

	Multiple Sclerosis Clinical Trials
	Neuro-Ophthalmology
	Neuroradiology of MS
	Neuroimmunology
	Neurorehabilitation

RECENT PUBLICATIONS

	Davis, S., Frohman, T.C., Brown, M., Mills, D., Crandall, C., Stuve, O., Frohman, E.M., "Modeling the pathophysiology of Uhthoff’s phenomenon in multiple sclerosis" Neurology, 70:1098-1106, 2008
	Frohman, E.M., Fujimoto, J.G., Frohman, T.C., Calabresi, P.A., Cutter, G., Balcer, L., "Imaging retinal architecture in multiple sclerosis with optical coherence tomography." Nature Neurology, 4:664-675., 2008
	Zaveri, M, Conger, A, Frohman, TC, Galetta, SL, Cutter, GR, Maguire, MG, Calabresi, PA, Balcer, LJ, Frohman, EM., "Retinal Imaging by Laser Polarimetry and optical coherence tomography Evidence of Axonal Degeneration in MS." Arch Neurol, 65:924-928, 2008
	Fox, RJ, McColl, RJ, Lee, J, Frohman, TC, Frohman EM., "A Validation Study of Diffusion tensor imaging as a measure of functional brain injury." Arch Neurol, 65:1179-1184, 2008
	Salter, AR, Conger, A, Frohman, TC, Zivadinov, R, Eggenberger, E, Calabresi, P, Cutter, G, Balcer, LJ, Frohman, EM, "Retinal architecture predicts pupillary reflex metrics in MS" Mult Scler (in press), 2008

SIGNIFICANT PUBLICATIONS

	Frohman, E.M., Goodin, D., Calabresi, P., et al, "The utility of MRI in suspeced MS. The Therapeutics and Technology Assessment Committee of the American Academy of Neurology." Neurology, 61:602-611, 2003
	Frohman, E.M., Raine, C. Racke, M.K., "Multiple Sclerosis: The plaque and its pathogenesis" New England Journal of Medicine, 354:942-955, 2006
	Frohman, E.M., Frohman, T.C., Zhang, H., Hawker, K., Racke, M.K., Frawley, W., Kramer, P.D., "Quantitative Oculographic Characterization of INO in MS." J Neurol Neurosurg Psychiatry, 73:51-55, 2002
	Frohman, E.M., Frohman, T.C., O?Suilleabhean, P., Dewey, R.B., Kramer, P.D., "A new measure of dysconjugacy in INO:The first-pass amplitude." J Neurol Sci, 210:65-71, 2003
	Zaveri, M, Conger, A, Frohman, TC, Galetta, SL, Cutter, GR, Maguire, MG, Calabresi, PA, Balcer, LJ, Frohman, EM., "Retinal Imaging by Laser Polarimetry and optical coherence tomography Evidence of Axonal Degeneration in MS." Arch Neurol, 65:924-928, 2008

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