Screening Breast Ultrasound in High Risk Women is a study comparing the cancer detection capability of breast ultrasound to that of mammography. This study is funded by the National Cancer Institute and The Avon Foundation. The greatest weakness of mammography in finding breast cancer is in women with dense breast tissue. Ultrasound seems to overcome this difficulty and find some breast cancers that are not seen with mammography. This investigation will determine the independent value of screening ultrasound in finding breast cancer in high risk women with dense breast tissue. The study is closed to accrual now. Women in the study will have a screening ultrasound and screening mammogram yearly for two years (three times), and these exams will be interpreted independently by different radiologists. The results of the study are expected in 2008.
A Multicenter, Prospective, Blinded-reader Study to Determine the Sensitivity and Specificity of the ComfortScan to Detect Malignancy as an Adjunct to Mammography in Patients < 50 Years of Age is sponsored by DOBI Medical International, Inc. The purpose of this research is to see if the ComfortScan system, which produces Dynamic Optical Breast Image (DOBI), can determine if certain breast masses are benign or malignant in younger women.
Cryoablation is a technique used at the Center for Breast Care to treat certain breast benign masses, such as fibroadenomas, by freezing the tumor. The freezing process destroys the unwanted tissue, and in most cases, the tumor disappears. The treatment is an office procedure performed through a small skin incision using ultrasound guidance. Later in 2006, a clinical trial will begin to determine if breast cancer can be successfully treated with this technique.
Tomosynthesis is a mammographic technique that has been developed as an adjunct to digital mammography. This method produces a three dimensional breast image that allows a radiologist to page through the breast tissue from one side of the breast to the other. It appears that it will be most useful in separating overlapping breast tissue structures which is the most common reason women are recalled for additional imaging from screening and finding cancer in dense breast tissue. Currently the tomosynthesis device is not FDA approved, and a clinical trial will begin later this year to determine its usefulness.
RECENT PUBLICATIONS
Evans WP, Warren-Burhenne LJ, Laurie L, O'Shaughnessy K, Castellion RA, "Invasive Lobular Carcinoma of the Breast: Mammographic Characteristics and Computer-Aided Detection" Radiology, Vol 225:182-189, 2002
Brenner RJ, Jackman R, Evans WP, Parker SH, Philpotts L, et al., "Percutaneous Core Needle Biopsy of Radial Scars: When Is Excision Necessary?" American Journal of Roentgenology, 179:1173-1184, 2002
Smith RA, Saslow D, Sawyer KA, Burke W, Costanza ME, Evans WP, Foster RS Jr., Hendrick E, Eyre HJ, Sener S, "American Cancer Society High-Risk Group; American Cancer Screening Older Women Work Group; American Cancer Society Breast Cancer Advisory Group: American Cancer Society Guidelines for Breast Cancer Screening" California Cancer J Clin., 53(3):141-169, May 2003
Spigel JJ, Evans WP, Grant MD, Langer TG, Krakos PA, Wise DK, ""Male Inflammatory Breast Cancer"" Clinical Breast Cancer, 153-155, July 2001
Brenner RJ, Bassett LW, Fajardo LL, Dershaw DD, Evans WP, Hunt R, et al., ""Stereotactic Core-Needle Breast Biopsy: A Multi-Institutional Prospective Trial"" Radiology, 218:866-872, 2001
SIGNIFICANT PUBLICATIONS
Evans WP, Cade SH, ""Needle Localization and Fine Needle Aspiration Biopsy of Non-Palpable Breast Lesions Using Standard and Stereotactic Equipment"" Radiology, 173:53-56, 1989
Evans WP, Starr AL, Bennos ER, ""Comparison of the Relative Incidence of Impalpable Invasive Breast Carcinoma in Situ in Cancers Detected in Patients Older and Younger than 50 Years of Age"" Radiology, 204:489-491, 1997
Evans WP, Warren-Burhenne LJ, Laurie L, O’Shaughnessy K, Castellino RA, ""Invasive Lobular Carcinoma of the Breast: Mammographic Characteristics and Computer-Aided Detection"" Radiology, 225:182-189, 2002
Brenner RJ, Jackman R, Evans WP, Parker SH, Philpotts L, et al., ""Percutaneous Core Needle Biopsy of Radial Scars: When Is Excision Necessary?"" American Journal of Roentgenology, 179:1173-1184, 2002
Smith RA, Saslow D, Sawyer KA, Burke W, Costanza ME, Evans WP, Foster RS Jr., Hendrick E, Eyre HJ, Sener S, "American Cancer Society High-Risk Work Group; American Cancer Society Screening Older Women Work Group; Ameican Cancer Society Mammography Work Group; American Cancer Society guidelines for Breast Cancer Screeing" California Cancer J Clin., 53(3):141-169, May 2003
Spigel JJ, Evans WP, Grant MD, Langer TG, Krakos PA, Wise DK, ""Male Inflammatory Breast Cancer"" Radiology, 153-155, July 2001
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