Our laboratory is interested in the molecular mechanisms through which CNS tissues respond to acute and chronic injury. This includes cellular and molecular pathways activated by acute injury which result in further secondary neurologic insults, as well as pathways that result in limiting secondary injury and fostering repair and regeneration. Work on animal models is focused on mechanisms of oxidative stress and lipid second messengers, particularly products of cytosolic phospholipase A2. Our group is also involved in patient-oriented studies in traumatic brain injury (TBI) and Alzheimer’s disease (AD), including studies of genetic factors influencing outcome after TBI and affecting rate of progression of AD. We are also involved in neuroimaging studies attempting to define endophenotypes of TBI and AD. Finally, our group is also involved in clinical trials in these two conditions.
RESEARCH INTERESTS
Genetic factors in outcome after TBI
Allelic association studies in AD
MRI Biomarkers in Traumatic Brain Injury
Homocysteine and one-carbon metabolism in aging and neurodegenerative disease.
