The focus of our research is directed at understanding human CD4+ T cell activation and cytokine production. Recent studies are focused on dissecting the mechanisms involved in the development of T helper-1 (Th-1) proinflammatory effector cells that secrete interferon-gamma, Th-2 effector cells that secrete cytokines such as IL-4 and regulatory T cells that downregulate inflammatory responses. Another goal is to identify lymphocyte cell surface markers and intracellular molecules that correlate with activation states or stages of post-thymic differentiation. Information gained from these studies is applied to investigations of chronic inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus. These studies will lead to a better understanding of the mechanisms involved in autoimmunity.
RESEARCH INTERESTS
T Lymphocyte Activation
Molecular Mechanisms Inducing Autoimmunity
RECENT PUBLICATIONS
BK Han, AM White, KH Dao, DR Karp, EK Wakeland and LS Davis, "Increased prevalence of activated CD70+ CD4+ T cells in the periphery of patients with systemic lupus erythematosus" Lupus, 14:598-606, 2005
J Hutcheson, JC Scatizzi, AM Siddiqui, GK Haines 3rd, T Wu, QZ Li, LS Davis, C Mohan and H Perlman., "Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity." Immunity, 28:206-217, February 2008
T Wu, X Qin, Z Kurepa, KR Kumar, K Liu, H Kanta, XJ Zhou, AB Satterthwaite, LS Davis and C Mohan., "Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus." J Clin Invest, 117(8):2186-2196, August 2007
AM Davis, HJ Ramos, LS Davis and JD Farrar, "Cutting Edge: A T-bet independent role for IFN-a/b in regulating IL-2 secretion in human CD4+ central memory T cells" J Immunol, 181:8204-8208, December 2008
A Luong, LS Davis and BF Marple, "Peripheral blood mononuclear cells from allergic fungal rhinosinusitis adults elicit a Th2 cytokine response to fungal antigens" Amer J Rhinology, (in press) 2009
SIGNIFICANT PUBLICATIONS
AF Kavanaugh, LS Davis, LA Nichols, SH Norris, R Rothlein, LA Scharschmidt and PE Lispky, "Treatment of refractory rheumatoid arthritis with a monoclonal antibody to intercellular adhesion molecule-1 (ICAM-1)" Arthritis and Rheumatism, 37:992-999, 1994
H Schulze-Koops, PE Lipsky, and LS Davis, "Differentiation of human memory T cells into Th2-like effector cells is dependent on IL-4 and CD28 stimulation and inhibited by T cell receptor ligation" European Journal of Immunology, 28:2517-2529, 1998
R Thomas, LS Davis and PE Lipsky, "Rheumatoid synovium is enriched in mature antigen-presenting dendritic cells" J Immunol, 152:2613-2623, 1994
LS Davis, AF Kavanaugh, LA Nichols and PE Lipsky, "Induction of persistent T cell hyporesponsiveness in vivo by monoclonal antibody to ICAM-1 in patients with rheumatoid arthritis" Journal of Immunology, 154:3523-3537, 1995
LS Davis, M Sackler, RI Brezinschek, E Lightfoot, JL Bailey, N Oppenheimer-Marks, PE Lipsky, "Inflammation, immune reactivity, and angiogenesis in a SCID model of rheumatoid arthritis" Amer J Pathol, 160:357-367, 2002
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