My research interests over the last decade have shifted from laboratory investigation and animal models of inflammatory skin disease to clinical investigation and to mentoring of young faculty members. This work includes development of a Pigmented Lesion Clinic for patients at risk for the development of malignant melanoma. In addition to caring for patients, we are working on scanning and computer-based technology that scans pigmented lesions several times over months and years and then through subtraction techniques identifies changes that signify radial growth, which typifies melanoma. I am also collaborating in studies that characterize localized scleroderma (morphea). Finally, I am engaged in a five-year term (2007 - 2012) as Editor-in-Chief of the major science journal for skin biology, the Journal of Investigative Dermatology.
RESEARCH INTERESTS
Photobiology
Melanoma
Inflammatory Skin Diseases
RECENT PUBLICATIONS
Yokota K, Takashima A, Bergstresser PR and Ariizumi K, "Identification of a Human Homologue of the Dendritic Cell-Associated C-Type Lectin-1, Dectin-1." Gene, 272:51-60, 2001
Ariizumi K, Shen G-L, Shikano S, Xu, Ritter R, Kumamoto T, Edelbaum D, Morita A, Bergstresser PR, and Takashima A, "Identification of a Novel, Dendritic Cell-associated Molecule, Dectin-1, by Subtractive cDNA Cloning." J Biol Chem, 275/26:20157-20167, 2000
Abeyama K, Eng W, Jester JV, Vink AA, Edelbaum D, Cockerell CJ, Bergstresser PR, Takashima A, "A Role for NF-kappaB-Dependent Gene Transactivation in Sunburn." J Clin Invest, 105:1751-1759, 2000
Matsue H, Edelbaum D, Hartmann AC, Morita A, Bergstresser PR, Yagita H, Okumura K, and Takashima A, "Dendritic Cells Undergo Rapid Apoptosis in In Vitro During Antigen-Specific Interaction with CD4+ T Cells." Journal of Immunology, 162:5287-5298, 1999
Sellati TJ, Waldrop SL, Salazar JC, Bergstresser PR, Picker LB and Radolf JD, "The Cutaneous Response in Humans to Treponema Pallidum Lipoproteins Analogues Involves Cellular elements of both Innate and Adaptive Immunity." Journal of Immunology, 166/6:4131-4140, 2001
SIGNIFICANT PUBLICATIONS
Lenz P, Elbe A, Stingl G, Bergstresser PR, "MHC Class I Expression on Dendritic Cells is Sufficient to Sensitize for Transplantation Immunity." Journal for Investigative Dermatology, 107:844-848, 1996
Cruz PD Jr, Tigelaar RE, Bergstresser PR, "Langerhans Cells that Migrate to Skin Following Intravenous Infusion Regulate the Induction of Contact Hypersensitivity" Journal of Immunology, 144:2486-2492, 1990
Streilein JW, Bergstresser PR, "Haptens can Serve as Surrogate Transplantation Antigens in a Manner that Demonstrates H-2 Restriction of Graft Rejection." J Exp Med, 157:1354-1359, 1983
Streilein JW, Lonsberry LW, Bergstresser PR, "Depletion of Epidermal Langerhans Cells and Ia Immunogenicity from Tape-Stripped Mouse Skin." J Exp Med, 155:863-871, 1982
Kitajima T, Caceres-Dittmar G, Tapia FJ, Jester J, Bergstresser PR, Takashima A, "T Cell-Mediated Terminal Maturation of Dendritic Cells: Loss of Adhesive and Phagocytotic Capacities." Journal of Immunology, 157:2340-2347, 1996
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