Center for Hypothalamic Research Gastroenterology Internal Medicine
RESEARCH INTERESTS
Bariatric Surgery
Obesity
Diabetes
Animal Models of Bariatric Surgery
RECENT PUBLICATIONS
Stylopoulos N and Aguirre V, "Mechanisms of bariatric surgery and implications for the development of endoluminal therapies for obesity." Gastrointestinal Endoscopy, ePub June 2009
Goldfine AB, Shoelson SE, Aguirre V, "Expansion and contraction: treating diabetes with bariatric surgery." Nature Medicine, 15(6):616-617, June 2009
Aguirre V, Stylopoulos N, Davis P, Grinbaum R, Kaplan L, "An endoluminal sleeve induces substantial weight loss and normalizes glucose homeostasis in rats with diet-induced obesity." Obesity, 16(12):2585-2592, December 2008
SIGNIFICANT PUBLICATIONS
Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF., "Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action." Journal of Biological Chemistry, 277(2):1531-1537, January 2002
Aguirre V, Uchida T, Yenush L, Davis R, White MF., "The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)." Journal of Biological Chemistry, 275(12):9047-9054, March 2000
Rui L, Aguirre V, Kim JK, Shulman GI, Lee A, Corbould A, Dunaif A, White MF., "Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways." Journal of Clinical Investigation, 107(2):181-189, January 2001
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