Human nuclear DNA is assembled into repeating macromolecular complexes termed chromatin. The structure of chromatin is tightly regulated by well choreographed actions of multiple elements. Disruption of the normal pattern of chromatin often leads to mis-regulation of gene expression, a common feature of cancer and other human diseases. The broad interests of my lab are to understand the specific regulatory events that control transcription initiation and elongation in a chromatin context. We will take advantage of combinatorial tools including biochemistry, genetics and genome-wide approaches to dissect the detailed molecular mechanisms.
RESEARCH INTERESTS
Chromatin Biology
Transcription Regulation
Biochemistry
Genetics
Genomics and Proteomics
RECENT PUBLICATIONS
Bing Li, Madelaine Gogol, Mike Carey, Daeyoup Lee, Chris Seidel and Jerry Workman, "Combined action of PHD and Chromo domains directs the Rpd3S HDAC to transcribed chromatin." Science, 316:1050-1054, 2007
Bing Li, Madelaine Gogol, Mike Carey, Samantha Pattenden, Chris Seidel and Jerry Workman, "Infrequently transcribed long genes depend on the Set2/Rpd3S pathway for accurate transcription" Genes& Development, 21/11:1422-30, 2007
Erica Larschan, Artyom A. Alekseyenko, Andrey A. Gortchakov, Shouyong Peng, Bing Li, Pok Yang, Jerry L. Workman, Peter J. Park, and Mitzi I. Kuroda, "MSL Complex Is Attracted to Genes Marked by H3K36 Trimethylation Using a Sequence-Independent Mechanism" Molecular Cell, 28/1:121-133, 2007
Chia-Hui Lin, Bing Li, Selene Swanson, Ying Zhang, Laurence Florens, Michael P. Washburn, Susan M. Abmayr and Jerry L. Workman, "Heterochromatin Protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase" Molecular Cell, 32(5):696-706, November 2008
Bing Li, Jessica Jackson, Matthew D. Simon, Brian Fleharty, Madelaine Gogol, Chris Seidel, Jerry L. Workman and Ali Shilatifard, "Histone H3 lysine 36 di-methylation (H3K36me2) is sufficient to recruit the Rpd3S histone deacetylase complex and to repress spurious transcription" J. Biol. Chem., 2009
SIGNIFICANT PUBLICATIONS
Bing Li, Madelaine Gogol, Mike Carey, Daeyoup Lee, Chris Seidel and Jerry Workman, "Combined action of PHD and Chromo domains directs the Rpd3S HDAC to transcribed chromatin." Science, 316:1050-1054, 2007
Bing Li, Madelaine Gogol, Mike Carey, Samantha Pattenden, Chris Seidel and Jerry Workman, "Infrequently transcribed long genes depend on the Set2/Rpd3S pathway for accurate transcription" Genes& Development, 21/11:1422-30, 2007
Bing Li, Michael Carey and Jerry Workman, "The role of chromatin during transcription" Cell, 128/4:707-719, 2007
M. Carrozza, Bing Li, Laurence Florens, Tamaki Suganuma, Selene Swanson, Kenneth Lee,Wei-Jong Shia, Scott Anderson, John Yates, Michael Washburn and Jerry Workman, "Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription" Cell, 123/4:581-592, 2005
Bing Li, Samantha Pattenden, Daeyoup Lee, Jose Gutierrez, Jie Chen, Chris Seidel, Jennifer Gerton and Jerry Workman, "Preferential occupancy of histone variant H2AZ at inactive promoters influence local histone modifications and chromatin remodeling" Proc. Natl. Acad. Sci. USA, 102/51:18385-18390, 2005
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