The Patrie lab is taking rotation students this fall.
Our interests range widely but generally are affiliated with understanding the roles post-translational modifications (PTMs) play in diseases such as autoimmune disorders and cancers. This includes developing state of the art Fourier Transform Mass Spectrometry (FTMS), Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS) and protein biochip technologies to simplify the discovery of PTMs and characterize their function.
Initially, we will apply these technologies in two distinct areas. The first is related to understanding of how PTMs drive interactions between proteins in gene transcription in cancer biology. The second is in the creation of a translational proteomics pipeline that rapidly identifies and validates PTM-based biomarkers in autoimmune disorders enabling a new class of early detection or prognostic tools for hospital laboratories.
Our lab seeks to transcend interdisciplinary research boundaries. To do so we are developing two labs. The first is in the Department of Internal Medicine at UTSW where we will focus on the discovery and characterization of novel PTMs. The second is in the Division of Materials Science and Engineering at UT at Dallas (UTD) where we will develop novel MS and protein array technologies to facilitate our efforts at UTSW.
RESEARCH INTERESTS
Translational Proteomics
Mass Spectrometry & protein biochips
Post-translational modifications
Gene Transcription & cancers
Autoimmune disorders
RECENT PUBLICATIONS
Patrie, S. M.; Mrksich, M., "Self-Assembled Monolayers for MALDI-TOF Mass Spectrometry for Immunoassays of Human Protein Antigens" Analytical Chemistry, 79/15:5878-87, August 2007
Patrie, S. M.; Ferguson, J. T. ; Robinson, D. E.; Rother, M.; Metcalf, W. W.; Kelleher, N. L., "Top-Down Mass Spectrometry of < 60 kDa Proteins from Methanosarcina acetivorans using Q-FTMS with Octopole Collisionally Activated Dissociation (OCAD)" Molecular and Cellular Proteomics, 1:14-25, January 2006
Patrie, S. M.; Mrksich, M., "Self-Assembled Monolayers for MALDI-TOF Mass Spectrometry for Immunoassays of Human Protein Antigens" Analytical Chemistry, 79/15:5878-87, August 2007
Patrie, S. M.; Charlebois, J. P.; Quinn, J. P.; Whipple, D.; Marshall, A. G. Hendrickson, C. L.; Kelleher, N. L., "Construction of a Hybrid Quadrupole / Fourier Transform Mass Spectrometer for Versatile MS/MS Above 10 kDa" Journal of the American Society of Mass Spectrometry, 15/7:1099-1108, July 2004
Patrie, S. M.; Robinson, D. E.; Meng, F.; Du, Y.; Kelleher, N. L., "Strategies for Automating Top Down Protein Analysis with Q-FTICR MS" International Journal of Mass Spectrometry, 234/1-3:175-184, 2004
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