Dr. Adinoff’s research has focused upon the neurobiologic alterations in chronic alcohol or cocaine dependent patients that may increase relapse risk. Using neuroendocrine and pharmacologic probes, examinations of cerebrospinal fluid, and neuroimaging (SPECT and fMRI) techniques, Dr. Adinoff explores both central nervous activity and peripheral stress-response systems in alcohol- and cocaine-dependent subjects.
RESEARCH INTERESTS
Neurobiology of Addictive Disorders
Neuroimaging and Neuroendocrine Probes of Alcohol and Drug Addiction
RECENT PUBLICATIONS
Porcu P, O?Buckley TK, Morrow AL, Adinoff B., "Differential hypothalamic-pituitary-adrenal activation of the neuroactive steroids pregnenolone sulfate and deoxycorticosterone in healthy controls and alcohol-dependent subjects." Psychoneuroendocrinology, 33:214-226, 2008
Schepis T, Adinoff B, Rao U, "Neurobiological processes in adolescent addictive disorders" Am J Addictions, 17:16-23, 2008
Hardin E, Adinoff B, "Family history of alcoholism does not influence adrenocortical hyporesponsiveness in abstinent alcohol-dependent men" Am J Drug Alcohol Abuse, 34:151-160, 2008
Adinoff B, Rilling LM, Williams MJ, Schreffler E, Schepis TS, Rosvall T, Rao U., "Impulsivity, neural deficits, and the addictions: The ’Oops’ factor in relapse." J Addict Dis., 26:25-39, 2007
Field C, Duncan J, Washington K, Adinoff B., "Association of baseline characteristics and motivation to change among patients seeking treatment for substance dependence." Drug Alcohol Depend, 91:77-84, 2007
SIGNIFICANT PUBLICATIONS
Adinoff B, Martin PR, Bone GHA, Eckardt MJ, Roehrich L, George DT, Moss H, Eskay R, Linnoila M, Gold PW, "Hypothalamic-pituitary-adrenal axis functioning and cerebrospinal fluid CRH and ACTH in alcoholics following recent and long term abstinence" Arch Gen Psychiatry, 47:325-330, 1990
Adinoff B, Risher-Flowers D, De Jong J, Ravitz B, Bone GHA, Nutt DJ, Roehrich L, Martin PR, Linnoila M, "Disturbances of hypothalamic-pituitary-adrenal axis functioning during the ethanol withdrawal syndrome in six men" American Journal of Psychiatry, 148:1023-1025, 1991
Adinoff B., "Neurobiological processes in drug reward and addiction." Harv Rev Psychiatry., 12:305-320, 2004
Adinoff B, Anton R, Linnoila M, Guidotti A, Nemeroff C, Bissette G, "Cerebrospinal fluid concentrations of corticotrophin-releasing hormone (CRH) and diazepam-binding inhibitor (DBI)during alcohol withdrawal and abstinence" Neuropsychopharmacology, 15:288-295, 1996
Adinoff B, Devous MD, Best S, George MS, Alexander D, Payne K., "Limbic responsiveness following IV procaine in cocaine addiction" American Journal of Psychiatry, 158:390-398, 2001
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