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Christian Forst

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Christian Forst, Ph.D.

Details of Research

Name:		Christian V Forst, Ph.D.
Academic Title:		Assistant Professor
Primary Appointment:		Clinical Sciences
School:		Graduate School of Biomedical Sciences
Degree Program:		Molecular Biophysics
Non-degree Program:		STARS
Department Website:		Department of Clinical Sciences
Email:		Christian Forst, Ph.D.

RESEARCH OVERVIEW

	Researcher in computational systems biology. Interested in host-pathogen interactions, drug response, drug development and emergence of infectious diseases as well as metagenomic analysis and multi-level biosystems comparisons. Applications include the study of infectious diseases caused by influenza virus and multidrug resistant M. tuberculosis.

RESEARCH INTERESTS

	Host-pathogen systems biology (Influenza, M. tuberculosis)
	Biological network reconstruction, comparison, dynamic simulation
	Metagenomic analysis from sparse data
	Computational systems biology tools development

RECENT PUBLICATIONS

	Gebert J., Motameny S., Faigle U., Forst C.V., Schrader R., "Identifying genes of gene regulatory networks using formal concept analysis" J. Comp. Biol., 15:185-194, 2008
	Forst C.V., Cabusora L., Mawuenyega K.G., and Chen X, "Biological Systems Analysis by a Network Proteomics Approach and Subcellular Protein Profiling" Adv. Complex Sys., 9:299-314, 2006
	Forst C.V., Flamm C., Hofacker I.L., Stadler P.F., "Algebraic Comparison of Metabolic Networks, Phylogenetic Inference, and Metabolic Innovation" Bioinformatics, 7:67, 2006
	Cabusora L., Sutton E., Fulmer A., Forst C.V., "Differential Network Expression During Drug and Stress Response" Bioinformatics, 21:2898-2905, 2005
	Mawuenyega K.G., Forst C.V., Dobos K.M., Belisle J.T., Chen J., Bradbury M.E., Bradbury A., Chen X., "Mycobacterium tuberculosis network analysis by global subcellular protein profiling" Mol. Biol. Cell, 16:396-404, 2005

SIGNIFICANT PUBLICATIONS

	Forst C.V., "Host-Pathogen Systems Biology" Drug Discovery Today, 11:220-227, 2006
	Forst C.V., and Schulten K., "Phylogenetic Analysis of Metabolic Pathways" J. Mol. Evol., 52:471-489, 2001
	Forst C.V., and Schulten K., "Evolution of Metabolisms: A new Method for the Comparison of Metabolic Pathways using Genomics Information" J. Comput. Biol., 64:343-360, 1999
	Forst,C.V., Reidys, C. and Weber,J., "Evolutionary Dynamics and Optimization" Lecture Notes in Artificial Intelligence (Advances in Artificial Life), 929 1995

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