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John Dietschy

 
 
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John Dietschy, M.D.

 Details of Research

Biographical Sketch Details of Research Personal Overview How to Contact
John Dietschy
Name:
  John M. Dietschy, M.D.
Endowed Title:
  The H. Ben and Isabelle T. Decherd Chair in Internal Medicine, in Honor of Henry M. Winans, Sr., M.D.
Academic Title:
  Professor
Primary Appointment:
  Internal Medicine - Digestive and Liver Diseases
School:
  Southwestern Medical School
Department Website:
  Internal Medicine - Digestive and Liver Diseases

 RESEARCH INTERESTS
 
Cholesterol metabolism
Lipoprotein metabolism
Malabsorption
Heart disease
Neurodegeneration
 
 RECENT PUBLICATIONS
 
Repa, J.J., Turley, S.D., Quan, G. and Dietschy, J.M., "Delineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption" J. Lipid Res., 46:779-789, 2005
Li, H., Repa, J.J., Valasek, M.A., Beltroy, E., Turley, S.D., German, D.C. and Dietschy, J.M., "Molecular, anatomical and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease" J. Neuropathol. Exp. Neurol., 64:323-333, 2005
Garver, W.S., Xie, C., Repa, J.J., Turley, S.D., Dietschy, J,M., "Niemann-Pick C1 expression is not regulated by the amount of cholesterol flowing through cells in the mouse" J. Lipid Res., 46:1745-1754, 2005
Beltroy, E.P., Richardson, J.A., Horton, J.D., Turley, S.D., Dietschy, J.M., "Cholesterol accumulation and liver cell death in the mouse with Niemann-Pick type C disease." Hepatology, 42:886-893, 2005
Xie C, Richardson JA, Turley SD, Dietschy JD, "Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein" J. Lipid Res., 47:953-963, 2006
 
 SIGNIFICANT PUBLICATIONS
 
Dietschy, J.M., "Mechanisms for the intestinal absorption of bile acids" J. Lipid Res., 9:297-309, 1968
Dietschy, J.M., Turley, S.D., and Spady, D.K., "Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans" J. Lipid Res., 34:1637-1659, 1993
Repa, J.J., Turley, S.D., Lobaccaro, J.-M.A., Medina, J., Li, L., Lustig, K. Shan, B., Heyman, R.A., Dietschy, J.M., Mangelsdorf, D.J., "Regulation of absorption and ABC1 mediated efflux of cholesterol by RXR heterodimers" Science, 289:1524-1529, 2000
Dietschy, J.M. and Wilson, J.D., "Regulation of cholesterol metabolism. (In three parts)" New Eng. J. Med., 282:1128-1138, 1179-1183, 1241-1249, 1970
Spady, D.K., Woollett, L.A. and Dietschy, J.M., "Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids" Annu. Rev. Nutr., 13:355-381, 1993
 
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