Dr. Chan is interested in both basic and applied studies of the human larynx at many different levels. In particular, the focus is on vocal fold tissue mechanics and biorheology, and their relationships with voice acoustics and laryngeal physiology. Another area of emphasis is tissue engineering and regenerative medicine, where various types of extracellular matrix scaffolds are being developed as tissue replacements for surgical applications. Our laboratory projects involve the use of cell culture models, animal models, physical models and computer models of the larynx.