Instructor (October 2005- Present) Department of Pathology, UT Southwestern Medical Center, Dallas. Project: Delineation of the signaling pathway regulating Forkhead transcription factors in the ovary.
Postdoctoral fellow (Jan 2004- August 2005) Department of Pathology, UT Southwestern Medical Center, Dallas. Project: Germ cell renewal in the mouse ovary and the role of Kit and Kit ligand in ovarian physiology. Achievments: (i) Studies have shown that germ cell renewal does not occur in the ovary. Futher studies have shown that Kit and Kit ligand do not have a role in controlling FoxO3 function in the ovary (Manuscript in preparation)
Post-doctoral Fellow (Jan 2001-Dec 2003) Department of Pathology, UT Southwestern Medical Center, Dallas. Project: Functional characterization of mitofilin. Achievements: (i) Studies led to the delineation of the role of mitofilin in maintaining the mitochondrial inner membrane structure (John et al, Mol Biol Cell 2005 Mar16(3):1543-1544). (ii) Worked on the knockout mouse model to delineate the in vivo function of mitofilin (manuscript in preparation).
Senior Research Fellow (Jan 1997- Dec 2000) Center for Cellular and Molecular Biology (CCMB), Hyderabad, India. Project: Mechanisms of apoptosis induction by the proapoptotic protein Bax. Achievements: (i) Studies showed that the mitochondrial import inhibition of Bax in normal cells can be overcome by a strong mitochondrial matrix targeting sequence and its localization to the mitochondrial membrane is necessary for proapoptotic function ( John et al, Exp Cell Res, Aug, 2002, 278, 198).
Junior Research Fellow (Aug 1994- Dec 1996) Center for Cellular and Molecular Biology (CCMB), Hyderabad, India. Project: Studies on the structure and function of membrane ion transporting cystine peptides. Achievements: (i) Developed novel fluorescence assays to monitor ion transport across membrane vesicles (Angew Chem Intl Ed Engl, 1996, 35, 1105). (ii) Structural charaterization of the cyclic novel depsipeptides with ion transport function (J Am Chem Soc, 1997, 119, 11578).
