Dr. Repa’s research at UT Southwestern focuses on the effects of diet and drugs on nuclear receptor regulation of gene expression, and how these signaling pathways contribute to such diseases as atherosclerosis and Type II diabetes. Her research is aimed at understanding the molecular mechanisms by which nuclear orphan receptors regulate lipid and carbohydrate metabolism in the liver, intestine and pancreatic beta-cell. The results of this research may provide clues to novel therapies for the treatment of these two very serious diseases.
