1980-1985 Graduate Research Assistant Department of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY Ph.D. Thesis Advisor: Efraim Racker, M.D.
1985-1987 Research Assistant Professor Dept. Internal Medicine, UT Southwestern Medical Center, Dallas, Texas
1987-1990 Assistant Professor of Physiology Department of Physiology, UT Southwestern Medical Center, Dallas, Texas
1987-present Member of Graduate Faculty, Graduate Program of Biological Chemistry, UT Southwestern Graduate school of Biomedical Sciences
1990-1998 Associate Professor of Internal Medicine and Physiology Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas
1998-present Professor of Internal Medicine Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas
2001-present Professor of Internal Medicine and Physiology McDermott Center for Human Growth and Development UT Southwestern Medical Center, Dallas, Texas
Research Projects Ongoing or Completed During the Last Three Years:
1. ?The Structure and Function of Mammalian V-type proton Translocation ATPases.? The long-term goal of this project is to determine the structural basis of the function and regulation of V-type proton pumps. The project characterizes the catalytic center and a regulatory component of the V-type proton pump of clathrin-coated vesicles and studies the isoform structure of the major subunits in its membrane domain to determine the structural basis for the regulation of this pump. 2. ?Structure and Function of ABCG5 and ABCG8.? The long-term goal of this project is to determine the structure and function of this newly discovered ABC transport system. The project in the current phase is focusing on the purification and biochemical characterization of both native ABCG5/8 transport system and the recombinant proteins. 3 ?Lipid asymmetry in plasma membrane and Apoptosis-induced PS exposure? The long-term goal of this project is to elucidate the mechanism by which the maintenance of lipid asymmetry in plasma membrane and PS exposure during apoptosis are regulated.
