Dr. Steven M. Patrie is an Endowed Scholar in the Division of Translational Research in the Department of Internal Medicine and holds a joint appointment with the Division of Material Sciences and Engineering at The University of Texas at Dallas. He received a B.S. in Chemistry from the University of Northern Iowa (1998) and a Ph.D. from the Department of Chemistry at the University of Illinois (2004). During his graduate career in Dr. Neil Kelleher’s Laboratory, Dr. Patrie constructed a Quadrupole-Fourier Transform Mass Spectrometer (Q-FTMS) and developed the first automation platform for top-down characterization of intact proteins and their post-translational modifications (PTMs). Dr. Patrie received a Post-Doctoral Scholar Award from the Department of Pathology at University of Chicago (2004). During this time he independently spearheaded the development of novel biochip & mass spectrometry assays that could translate protein or PTM candidate biomarkers into the clinical laboratories. This work included close interactions with physician-scientists in the Department of Pathology, UC Hospital Laboratories, as well as, an extensive collaboration with Dr. Milan Mrksich’s materials science laboratory in the Department of Chemistry.
Dr. Patrie’s interests range widely but generally are affiliated with understanding the roles PTMs play in autoimmune disorders and cancer biology; and developing mass spectrometry and protein biochip technologies to simplify PTM analysis. Dr. Patrie’s interdisciplinary labs at both UTSW and UTD will allow 1) understanding of how PTMs drive interactions between proteins in diseased cell signaling pathways and in gene trascription; 2) the development of novel therapies that antagonize deleterious signaling driven by PTMs; and 3) the creation of a translational proteomics pipeline that rapidly identifies and validates PTM-based biomarkers enabling a new class of early detection or prognostic tools for hospital laboratories.
