Cyclotron and Radiochemistry
The Cyclotron and Radiochemistry Program is a UT Southwestern Medical Center-wide effort to develop the full capability of nuclear imaging, namely radioisotope-based imaging, for noninvasive assessment of biological processes and abnormalities in preclinical models and in humans. Its mission is to facilitate translation of basic biomedical research into clinical practice.
The Cyclotron and Radiochemistry facility has been fully operational since January 2015. Equipped with a GE PETrace cyclotron (16.5 MeV and 130 µA of proton beam), the facility is capable of routine production of [15O], [13N], [11C], [18F] and other longer-lived radioisotopes (e.g., 64Cu and 89Zr) at high specific radioactivity for the development of novel radiotracers for Positron Emission Tomography (PET) in a research radiochemistry laboratory and the current good manufacturing practice (CGMP) production and delivery of PET radiopharmaceuticals for human use in full compliance with the U.S. Food and Drug Administration's 21 CFR Part 212 and the United States Pharmacopeia Chapter 823.
In addition, the Program has a preclinical nuclear imaging laboratory that's equipped with two state-of-the-art small animal nuclear imaging scanners (Siemens Inveon PET/CT Multimodality System and NanoSPECT/CT Plus system) and a fully operational radiochemistry research facility.