Clinical Research by Disease

The Department of Radiation Oncology enrolls as many as 80 new patients each year in clinical trials. Faculty members hold leadership positions in the Radiation Therapy Oncology Group (RTOG), which develops and oversees all national radiation oncology trials funded by the National Cancer Institute.

See current clinical trial information below or contact the Clinical Research office at 214-648-5536.

Brain

Randomized, Phase Il, Double-Blind, Placebo-Controlled Trial Of Conventional Chemoradiation And Adjuvant Temozolomide Plus Cediranib Versus Conventional Chemoradiation And Adjuvant Temozolomide Plus Placebo In Patients With Newly Diagnosed Glioblastoma
RTOG 0837
Principal Investigator: Hak Choy, MD — Coordinator: Jessica Crockett, CCRP

Interstitial Radioactive Iodine Implants for the Treatment of Pan-invasive Pituitary Macroadenomas
042011-075
Principal Investigator: Robert Timmerman, MD — Coordinator: Jessica Crockett, CCRP
 
Phase II trial of Hippocampal-Avoiding Whole Brain Irradiation with Simultaneous Integrated Boost for Treatment of Brain Metastases
042011-050
Principal Investigator: Robert Timmerman, MD — Coordinator: Jessica Crockett, CCRP

E3F05 Phase III Study of Radiation Therapy with or without Temozolomide for Symptomatic or Progressive Low-Grade Gliomas
E3F05
Coordinator: Jessica Crockett, CCRP

Breast

A Phase I Study of CyberKnife® Partial Breast Irradiation (PBI) for Early Stage Breast Cancer
042010-052
Principal Investigator: Robert Timmerman, MD — Coordinator: Laurin Loudat

A Phase II Study of Repeat Breast Preserving Surgery and 3D-Conformal Partial Breast Re-Irradiation (PBRI) For Local Recurrence of Breast Carcinoma
RTOG 1014
Principal Investigator: Ann Spangler, MD — Coordinator: Jessica Crockett, CCRP

A Phase III Trial Of Accelerated Whole Breast Irradiation With Hypofractionation Plus Concurrent Boost Versus Standard Whole Breast Irradiation Plus Sequential Boost For Early-Stage Breast Cancer
RTOG 1005
Coordinator: Jessica Crockett, CCRP

Gastrointestinal

Dose Escalating Study of Single Fraction Stereotactic Body Radiation Therapy (SBRT) for Patients with Hepatic Metastases
052010-013
Radiation Oncology Investigator: Jeffrey Meyer, MD — Coordinator: Irma Smith

A Pilot and Phase II Study of Altered Chemotherapy Sequencing During Neoadjuvant Therapy for Patients with Stage II or III Rectal Adenocarcinoma
082010-335 Rectal Study
Principal Investigator: Jeffrey Meyer, MD —Coordinator: Jessica Crockett

Gynecologic

A Phase III Trial of Pelvic Radiation Therapy Versus Vaginal Cuff Brachytherapy Followed by Paclitaxel/Carboplatin in Patients with High-Risk, Early Stage Endometrial Cancer
GOG 0249
Radiation Oncology Investigator: Kevin Albuquerque, MD — Coordinator: Melana Weir

A randomized trial of pelvic irradiation with or without concurrent weekly cisplatin in patients with pelvic-only recurrence of carcinoma of the uterine corpus
GOG 0238
Radiation Oncology Investigator: Kevin Albuquerque, MD 

A randomized phase III trial of cisplatin and tumor volume directed irradiation followed by carboplatin and paclitaxel vs. carboplatin and paclitaxel for optimally debulked, advanced endometrial carcinoma
GOG 0258
Radiation Oncology Investigator: Kevin Albuquerque, MD

Phase III Randomized Study of Concurrent Chemotherapy and Pelvic Radiation Therapy with or without Adjuvant Chemotherapy in High-Risk Patients with Early-stage Cervical Carcinoma Following Radical Hysterectomy
GOG 0724
Radiation Oncology investigator: Kevin Albuquerque, MD — Coordinator: Paula Rogers

A Phase I Trial of Tailored Radiation Therapy With Concomitant Cetuximab (C225, NSC #714692) and Cisplatin (NSC #119875) in the Treatment of Patients with Cervical Cancer
GOG 9918
Radiation Oncology investigator: Kevin Albuquerque, MD — Coordinator: Paula Rogers

Head and Neck

A Phase II Multi-Center Study of Concomitant Cetuximab and Cisplatin with Re-irradiation Using Intensity-Modulated Radiotherapy (IMRT) in Patients with Recurrent Squamous Cell Carcinoma of the Head and Neck
BMS CA 225314
Principal Investigator: Lucien Nedzi, MD —  Coordinator: Irma Charles, MS

A Phase I/II Study of Nab-paclitaxel, Cisplatin and Cetuximab With Concurrent Radiation Therapy for Local-Regionally Advanced Head-and-Neck Squamous Cell Carcinoma
Principal Investigator: Lucien Nedzi, MD — Coordinator: Susan Cooley, RN

RTOG 0920 A Phase III Study of Postoperative Radiation Therapy (IMRT) /- Cetuximab for Locally-Advanced Resected Head and Neck Cancer
RTOG 0920
Principal Investigator: Lucien Nedzi, MD — Coordinator: Irma Smith

A Randomized Phase II Study of Adjuvant Concurrent Radiation and Chemotherapy Versus Radiation Alone in Resected High-Risk Malignant Salivary Gland Tumors
RTOG 1008
Principal Investigator: Lucien Nedzi, MD — Coordinator: Gary Stuard

Lung (Thoracic)

Small Cell Lung Cancer

A Phase III Comparison of Thoracic Radiotherapy Regimes With Cisplatin and Etoposide In Limited Small Cell Lung Cancer
CALGB 30610/RTOG 0538
Principal Investigator: Hak Choy, MD — Coordinator: Laurin Loudat

Non-Small Cell Lung Cancer

Stage I

A Randomized Phase III Study of Sublobar Resection (+/- Brachytherapy) versus Stereotactic Body Radiation Therapy in High Risk Patients with Stage I NSCLC
RTOG 1021
Principal Investigator: Robert Timmerman, MD — Coordinator: Irma Smith, CCRP

Locally Advanced (Stage III) or Inoperable (Stage I or Stage II)

A Randomized Phase III Comparison of Standard-Dose (60 Gy) Versus High-Dose (74 Gy) Conformal Radiotherapy With Concurrent and Consolidation Carboplatin/Paclitaxel /- Cetuximab (IND #103444) In Patients With Stage IIIA/IIIB Non-Small Cell Lung Cancer
RTOG 0617
Principal Investigator: Hak Choy, MD — Coordinator: Laurin Loudat

Seamless Phase I/II Study of Stereotactic Body Radiotherapy (SBRT) For Early Stage, Centrally Located Non-Small Cell Lung Cancer (NSCLC) In Medically Inoperable Patients
RTOG 0813
Principal Investigator: Robert Timmerman, MD — Coordinator: Irma Charles, MS

Phase I Study of Accelerated Hypofractionated Image-Guided Radiation Therapy (IGRT) in Patients with Stage II-IV Non-Small Cell Lung Cancer and Poor Performance Status
072009-061
Principal Investigator: Robert Timmerman, MD — Coordinator: Laurin Loudat

Metastatic (2 or more sites)

A Phase II Trial of Erlotinib (Tarceva®) In Combination With Stereotactic Body Radiation Therapy (SBRT) For Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
42007003
Principal Investigator: Robert Timmerman, MD — Coordinator: Irma Charles, MS

Prostate and Bladder

A Phase III Trial Of Short Term Androgen Deprivation With Pelvic Lymph Node Or Prostate Bed Only Radiotherapy (SPPORT) In Prostate Cancer Patients With A Rising PSA After Radical Prostatectomy
RTOG 534
Coordinator: Susan Cooley, RN

A Phase III Prospective Randomized Trial of Dose-Escalated Radiotherapy With or Without Short-Term Androgen Deprivation Therapy for Patients With Intermediate-Risk Prostate Cancer
RTOG 0815
Principal Investigator: David Pistenmaa, MD — Coordinator: Susan Cooley, RN

Spine

A Phase II Study of Stereotactic Body Radiation Therapy and Vertebroplasty for Localized Spine Metastasis
SCCC-03Z08
Principal Investigator: Robert Timmerman, MD — Coordinator: Susan Cooley, RN

A Phase II/III Study of Image-guided Radiosurgery/SBRT for Localized Spine Metastasis
RTOG 0631
Principal Investigator: Robert Timmerman, MD — Coordinator: Laurin Loudat

General Non-therapeutic

Tissue Procurement and Outcome Collection for Radiotherapy Treated Patients 
Principal Investigator: Hak Choy, MD –- Coordinator: Gary Stuard