Research

Researchers in the Division of Molecular Radiation Biology seek to understand the molecular mechanisms behind critical cellular responses to ionizing radiation (including DNA repair, cellular proliferation, and inflammation), as well as to develop biological markers that predict how an individual may respond. Their research encompasses several areas of investigation, including:

  • Radiation resistance and radiation sensitization
  • DNA double-strand break repair
  • Prognostic markers for therapeutic outcomes
  • Biology of stereotactic body radiation therapy (SBRT)
  • Space radiation biology

Todd Aguilera Lab

  • Understand factors that influence immune heterogeneity in the tumor microenvironment
  • Investigate mechanisms of immune privilege that can enhance immunotherapy efficacy
  • Explore tolerogenic and immunogenic mechanisms activated by radiation

Prasanna Alluri Lab

  • Molecular mechanisms of endocrine therapy- and CDK 4/6 inhibitor-resistance in breast cancer
  • Targeting epigenetic pathways to overcome treatment resistance in breast cancer
  • New therapeutic approaches to mitigate radiation-induced heart disease

Asaithamby Aroumougame Lab

  • Radio-immunotherapy in cancer prevention and treatment
  • Molecular understanding of the pathophysiology of Werner Syndrome
  • Heart damage associated with radiotherapy and space radiation

Sandeep Burma Lab

  • Genetic basis of radioresistance of glioblastomas
  • Particle radiation and carcinogenesis (NASA)
  • Sensing, signaling, and repair of DNA double-strand breaks

Benjamin Chen Lab

  • DNA damage response and repair
  • Genomic instability and cancer development
  • Radiation biology

David Chen Lab

  • DNA damage responses induced by HZE particles in human cells
  • Structural cell biology of DNA repair machines
  • The role of DNA-PK in DNA double-strand break repair

Anthony Davis Lab

  • Cellular response to DNA damage
  • The role of aberrant DNA repair and signaling in cancer etiology
  • The role of the DNA-PK complex in repairing DNA damage

Raquibul Hannan Lab

  • Innate and adaptive immune responses generated by tumor irradiation with stereotactic ablative radiotherapy (SAbR)
  • Investigate strategies to combine immunotherapy with SAbR (i-SAbR) for cancer treatment
  • Improve cancer patient treatment outcome through the design of i-SAbR clinical trials

Puneeth Iyengar Lab

  • Metabolic and immune regulation of cancer cachexia
  • Lung cancer tumor metabolism
  • Inflammation driven radiation resistance of lung cancer

Guo-Min Li Lab

  • Genetic and epigenetic regulations of DNA mismatch repair
  • Targeting DNA repair on cancer therapy
  • Mechanism of trinucleotide repeat expansion and neurodegenerative disorders

Debabrata Saha Lab

  • The role of DAB2IP in chromosome stability
  • Developing physiologically relevant tumor models that improve preclinical predictions and translational success
  • Developing drug delivery system using nanoparticles

Michael Story Lab

  • Carcinogenesis associated with HZE particle exposure
  • Intrinsic radiosensitivity
  • Modulation of drug and radiation response by GSTO expression
  • Molecular markers of radioresponse
  • Radiotherapy research: SBRT and other

Kenneth Westover Lab

  • Structural biology of cancer-associated proteins
  • Drug development for cancer therapy
  • Biochemistry and chemical biology