Faculty

David Mangelsdorf, Ph.D.
Professor of Pharmacology and Biochemistry
Chair of Pharmacology
Raymond and Ellen Willie Distinguished Chair in Molecular Neuropharmacology in Honor of Harold B. Crasilneck, Ph.D.
Investigator, Howard Hughes Medical Institute
Lab
Phone: 214-645-5957
davo.mango@utsouthwestern.edu

The Mango/Kliewer lab is interested in understanding the physiologic role of nuclear hormone receptors and endocrine fibroblast growth factors in regulating metabolic processes. A further goal of our work is to exploit the signaling networks governed by these factors to discover novel therapeutic options for diseases, such as atherosclerosis, cholestasis, obesity, cancer, and nematode parasitism.


Joseph Albanesi, Ph.D.
Professor of Pharmacology
Phone: 214-645-6119
joseph.albanesi@utsouthwestern.edu

Research projects in our lab are investigating the dysregulation of dynamin in neuromyopathies and the role of phosphoinositides in endocytic trafficking.


Yuh Min Chook, Ph.D.
Professor of Pharmacology
Lab
Phone: 214-645-6167
yuhmin.chook@utsouthwestern.edu

Research in our lab is directed toward understanding the physical and cellular mechanisms of nuclear trafficking by the Karyopherin-β family of proteins. We would like to understand how the macromolecular nuclear traffic patterns coordinated by the 19 human Karyopherin-βs contribute to overall cellular organization.


Melanie Cobb, Ph.D.
Professor of Pharmacology
Jane and Bill Browning, Jr. Chair in Medical Science
Phone: 214-645-6122
melanie.cobb@utsouthwestern.edu

My laboratory investigates signal transduction mechanisms, in particular MAPK and other protein kinase pathways. In addition to a focus on nutrient regulation in pancreatic beta cells and neuroendocrine cancers, we examine functions of the unusual WNK protein kinases in regulation of ion homeostasis, vesicular trafficking, and regulation of RNA binding proteins.


David Corey, Ph.D.
Professor of Pharmacology and Biochemistry
Lab
Phone: 214-645-6155
david.corey@utsouthwestern.edu

Modulation of gene expression with nucleic acids.


Alfred Gilman, M.D., Ph.D.
Regental Professor of Pharmacology Emeritus
aggilman@gmail.com

Dr. Gilman, Chairman of the Department from 1981-2006 and former Dean of Southwestern Medical School, is best known for discovery and characterization of signal-transducing G proteins and mechanisms of regulation of cyclic AMP synthesis by these proteins.


Joel Goodman, Ph.D.
Professor of Pharmacology
Jan and Bob Bullock Distinguished Chair for Science Education
Director, UT Southwestern STARS Program
Lab
Phone: 214-645-6139
joel.goodman@utsouthwestern.edu

Organelle biogenesis and associated protein and lipid trafficking, focused on understanding the assembly and maintenance of cytoplasmic lipid droplets.


Kent Hamra, Ph.D.
Assistant Professor of Pharmacology
Lab
Phone: 214-645-6279
kent.hamra@utsouthwestern.edu

Research in our laboratory is based on the biology and applications of sperm stem cells. Areas of focus include: understanding the genetic basis of sperm development, which will lead to new therapies to correct infertility; the discovery of novel contraceptive targets; insights into innovative cancer therapies; the design of original cellular therapeutics for regenerative medicine; and the production of advanced animal models to support drug discovery and to facilitate translational research.


Bethany Janowski, Ph.D.
Associate Professor of Pharmacology
Phone: 214-645-6109
bethany.janowski@utsouthwestern.edu

Our research focuses on understanding how non-coding RNAs regulate gene expression. We are also using small RNAs to modulate the expression of oncogenes and tumor suppressor genes in cancer cells.


Steven Kliewer, Ph.D.
Professor of Molecular Biology and Pharmacology
Lab
Phone: 214-645-6304
steven.kliewer@utsouthwestern.edu

The Mango/Kliewer lab is interested in understanding the physiologic role of nuclear hormone receptors and endocrine fibroblast growth factors in regulating metabolic processes. A further goal of our work is to exploit the signaling networks governed by these factors to discover novel therapeutic options for diseases such as atherosclerosis, cholestasis, obesity, cancer, and nematode parasitism.


Mark Lehrman, Ph.D.
Professor of Pharmacology
Phone: 214-645-6172
mark.lehrman@utsouthwestern.edu

We study processes in health and disease which depend upon the synthesis and recognition of glycoconjugates, which are polysaccharides coupled to proteins and lipids. Our focus is on the stress signaling pathways of the endoplasmic reticulum, a major site for glycoconjugate production.


Xuelian Luo, Ph.D.
Associate Professor of Pharmacology
Phone: 214-645-6368
xuelian.luo@utsouthwestern.edu

Our work focuses on the structure and biology of signaling proteins in the Hippo pathway for organ size control, and structural and biochemical studies of the spindle checkpoint in chromosome segregation.


Elisabeth Martinez, Ph.D.
Assistant Professor of Pharmacology
Phone: 214-648-5150
elisabeth.martinez@utsouthwestern.edu

The goal of our research is to identify novel chemical modulators of transcriptional and epigenetic pathways with application in disease models, particularly in cancer, and to use these chemical tools to dissect new aspects of disease biology.


Anthony Michael, Ph.D.
Associate Professor of Pharmacology
Phone: 214-648-4170
anthony.michael@utsouthwestern.edu

Our research is focused on understanding the evolution and biological function of metabolic pathways by using a multidisciplinary approach encompassing comparative and functional genomics, protein structure analysis, biochemistry, analytical chemistry, genetics and molecular biology.


Margaret Phillips, Ph.D.
Professor of Pharmacology
Phone: 214-645-6164
margaret.phillips@utsouthwestern.edu

Research in the Phillips lab focuses on essential metabolic enzymes in the parasitic protozoa that cause African sickness (Trypanosoma brucei) and Malaria (Plasmodium falciparum), both significant contributors to global health problems. We are focused on both biochemical understanding of parasite metabolism and on exploiting the identified processes for drug discovery.


Michael Reese, Ph.D.
Assistant Professor of Pharmacology
Lab
Phone: 214-645-5843
michael.reese@utsouthwestern.edu

The Reese lab combines molecular genetics, cell biology, and biophysics to determine how a pathogen's influence on signal transduction can alter disease.


Elliott Ross, Ph.D.
Professor of Pharmacology
Greer Garson and E. E. Fogelson Distinguished Chair in Medical Research
Lab
Phone: 214-645-6134
elliott.ross@utsouthwestern.edu

Ross' group studies how cells process information, particularly through heterotrimeric G proteins: the molecular mechanisms used to detect, sort, amplify and convey information, and how these mechanisms are regulated to provide G protein signaling modules with adaptability and diversity.


Dean Smith, M.D., Ph.D.
Professor of Pharmacology
Lab
Phone: 214-648-1650
dean.smith@utsouthwestern.edu

The Smith lab is interested in the molecular basis of behavior, using volatile pheromone signaling and information processing in Drosophila as a model system.


Paul Sternweis, Ph.D.
Professor of Pharmacology
Alfred and Mabel Gilman Chair in Molecular Pharmacology
Director, Cell Regulation Graduate Program
Phone: 214-645-6149
paul.sternweis@utsouthwestern.edu

Our research focuses on elucidation of pathways and mechanisms by which cell surface receptors regulate intracellular function. Current studies, which center on G protein pathways, combine biochemical, structural, fluorescent, and cell-based techniques to gain better understanding of both molecular mechanisms and physiological impact of these pathways.


Ronald Taussig, Ph.D.
Associate Professor of Pharmacology
Phone: 214-645-6146
ronald.taussig@utsouthwestern.edu

Research in my laboratory focuses on signal transduction processes that are mediated by heterotrimeric G proteins. We employ a variety of approaches including biochemical, genetic, and cell based assays toward understanding the regulation of adenylyl cyclase and intracellular cyclic AMP.


Yihong Wan, Ph.D.
Assistant Professor of Pharmacology
Lab
Phone: 214-645-6062
yihong.wan@utsouthwestern.edu

To understand the transcriptional regulation of development, metabolism and cancer using the skeleton and mammary gland as model systems.


Thomas Wilkie, Ph.D.
Associate Professor of Pharmacology
Lab
Phone: 214-645-6175
thomas.wilkie@utsouthwestern.edu

We study G protein coupled receptor signaling regulating pancreas development, beta cell regeneration in diabetes, and aberrant cell growth and metastasis in pancreatic ductal adenocarcinoma.


Hongtao Yu, Ph.D.
Professor of Pharmacology
Investigator, Howard Hughes Medical Institute
Lab
Phone: 214-645-6161
hongtao.yu@utsouthwestern.edu

We study the cellular mechanisms that maintain chromosomal stability using a multidisciplinary approach.


Xuewu Zhang, Ph.D.
Assistant Professor of Pharmacology and Biochemistry
Lab
Phone: 214-645-6116
xuewu.zhang@usouthwestern.edu

Our laboratory is focused on studying signaling and regulation mechanisms of cell surface receptors, such as the neuron axon guidance receptors plexins. We use multidisciplinary approaches including X-ray crystallography, biophysical, biochemical, and cell-based analyses in our studies.