David Mangelsdorf, Ph.D.
Professor of Pharmacology and Biochemistry
Chair of Pharmacology
Raymond and Ellen Willie Distinguished Chair in Molecular Neuropharmacology in Honor of Harold B. Crasilneck, Ph.D.
Investigator, Howard Hughes Medical Institute
The Mango/Kliewer lab is interested in understanding the physiologic role of nuclear hormone receptors and endocrine fibroblast growth factors in regulating metabolic processes. A further goal of our work is to exploit the signaling networks governed by these factors to discover novel therapeutic options for diseases, such as atherosclerosis, cholestasis, obesity, cancer, and nematode parasitism.
Research projects in our lab are investigating the dysregulation of dynamin in neuromyopathies and the role of phosphoinositides in endocytic trafficking.
The Altschuler/Wu Lab studies how signaling networks in chemotaxis, metabolism, and development give rise to predictable behaviors in unpredictable environments, and how predictability is lost in disease states, such as cancer.
Research in our lab is directed toward understanding the physical and cellular mechanisms of nuclear trafficking by the Karyopherin-β family of proteins. We would like to understand how the macromolecular nuclear traffic patterns coordinated by the 19 human Karyopherin-βs contribute to overall cellular organization.
My laboratory investigates signal transduction mechanisms, in particular MAPK and other protein kinase pathways. In addition to a focus on nutrient regulation in pancreatic beta cells and neuroendocrine cancers, we examine functions of the unusual WNK protein kinases in regulation of ion homeostasis, vesicular trafficking, and regulation of RNA binding proteins.
Modulation of gene expression with nucleic acids.
Dr. Gilman, Chairman of the Department from 1981-2006 and former Dean of Southwestern Medical School, is best known for discovery and characterization of signal-transducing G proteins and mechanisms of regulation of cyclic AMP synthesis by these proteins.
Joel Goodman, Ph.D.
Professor of Pharmacology
Jan and Bob Bullock Distinguished Chair for Science Education
Director, UT Southwestern STARS Program
Organelle biogenesis and associated protein and lipid trafficking, focused on understanding the assembly and maintenance of cytoplasmic lipid droplets.
Research in our laboratory is based on the biology and applications of sperm stem cells. Areas of focus include: understanding the genetic basis of sperm development, which will lead to new therapies to correct infertility; the discovery of novel contraceptive targets; insights into innovative cancer therapies; the design of original cellular therapeutics for regenerative medicine; and the production of advanced animal models to support drug discovery and to facilitate translational research.
Our research focuses on understanding how non-coding RNAs regulate gene expression. We are also using small RNAs to modulate the expression of oncogenes and tumor suppressor genes in cancer cells.
The Mango/Kliewer lab is interested in understanding the physiologic role of nuclear hormone receptors and endocrine fibroblast growth factors in regulating metabolic processes. A further goal of our work is to exploit the signaling networks governed by these factors to discover novel therapeutic options for diseases such as atherosclerosis, cholestasis, obesity, cancer, and nematode parasitism.
We study processes in health and disease which depend upon the synthesis and recognition of glycoconjugates, which are polysaccharides coupled to proteins and lipids. Our focus is on the stress signaling pathways of the endoplasmic reticulum, a major site for glycoconjugate production.
Our work focuses on the structure and biology of signaling proteins in the Hippo pathway for organ size control, and structural and biochemical studies of the spindle checkpoint in chromosome segregation.
Elisabeth Martinez, Ph.D.
Assistant Professor of Pharmacology
The goal of our research is to identify novel chemical modulators of transcriptional and epigenetic pathways with application in disease models, particularly in cancer, and to use these chemical tools to dissect new aspects of disease biology.
Anthony Michael, Ph.D.
Associate Professor of Pharmacology
Our research is focused on understanding the evolution and biological function of metabolic pathways by using a multidisciplinary approach encompassing comparative and functional genomics, protein structure analysis, biochemistry, analytical chemistry, genetics and molecular biology.
Research in the Phillips lab focuses on essential metabolic enzymes in the parasitic protozoa that cause African sickness (Trypanosoma brucei) and Malaria (Plasmodium falciparum), both significant contributors to global health problems. We are focused on both biochemical understanding of parasite metabolism and on exploiting the identified processes for drug discovery.
Rama Ranganathan, M.D., Ph.D.
Professor of Pharmacology
Director, Division of Systems Biology of the Green Center for Systems Biology
Cecil H. and Ida M. Green Chair in Biomedical Science
The central goal of our laboratory is to understand the principles underlying the evolutionary "design" of biological systems. We work on this problem at both the atomic and cellular scales.
Ross' group studies how cells process information, particularly through heterotrimeric G proteins: the molecular mechanisms used to detect, sort, amplify and convey information, and how these mechanisms are regulated to provide G protein signaling modules with adaptability and diversity.
The Smith lab is interested in the molecular basis of behavior, using volatile pheromone signaling and information processing in Drosophila as a model system.
Our research focuses on elucidation of pathways and mechanisms by which cell surface receptors regulate intracellular function. Current studies, which center on G protein pathways, combine biochemical, structural, fluorescent, and cell-based techniques to gain better understanding of both molecular mechanisms and physiological impact of these pathways.
Research in my laboratory focuses on signal transduction processes that are mediated by heterotrimeric G proteins. We employ a variety of approaches including biochemical, genetic, and cell based assays toward understanding the regulation of adenylyl cyclase and intracellular cyclic AMP.
To understand the transcriptional regulation of development, metabolism and cancer using the skeleton and mammary gland as model systems.
We study G protein coupled receptor signaling regulating pancreas development, beta cell regeneration in diabetes, and aberrant cell growth and metastasis in pancreatic ductal adenocarcinoma.
The Altschuler/Wu Lab studies how signaling networks in chemotaxis, metabolism, and development give rise to predictable behaviors in unpredictable environments, and how predictability is lost in diseases states, such as cancer.
We study the cellular mechanisms that maintain chromosomal stability using a multidisciplinary approach.
Our laboratory is focused on studying signaling and regulation mechanisms of cell surface receptors, such as the neuron axon guidance receptors plexins. We use multidisciplinary approaches including X-ray crystallography, biophysical, biochemical, and cell-based analyses in our studies.