Dr. Diego Castrillon receives $900K grant from The Cancer Prevention and Research Institute of Texas

Congratulations to Dr. Diego Castrillon, Associate Professor of Pathology, for being awarded a $900,000 grant from The Cancer Prevention and Research Institute of Texas to study the LKB1 tumor suppressor gene.

The LKB1 tumor suppressor is inactivated in a wide range of incurable malignancies, including several cancers that arise in women (endometrial and cervical cancer). Cancers characterized by LKB1 inactivation tend to spread rapidly and are particularly lethal. However, relatively little is known about how LKB1 inactivation leads to cancers with a particularly poor prognosis. This project  seeks to understand the diverse biological actions of LKB1 and how these actions work together in driving tumor initiation and spread in different types of cancers of the uterus including endometrial and cervical cancer. The goal is to gain a sufficient understanding of how LKB1 causes cancer to facilitate the development and implementation of effective therapeutic combinations that will specifically target these women’s cancers caused by LKB1 inactivation.