Hasan Zaki, Ph.D., joins Pathology Department
Hasan Zaki, Ph.D., Assistant Professor of Pathology, studies gastrointestinal inflammation and cancer. His research interests include host-pathogen interaction, the role of pathogen sensors in intestinal inflammation and cancer, pathogenic mechanisms of inflammatory bowel disease and colorectal cancer, and identifying immune checkpoints of gastrointestinal disorders that could be targeted for therapeutic intervention and drug development.
Dr. Zaki earned his undergraduate and master's degrees in microbiology at the University of Dhaka, Bangladesh. He then joined the International Center for Diarrheal Disease Research, Bangladesh, where he studied immune responses against enteric pathogens. He did his doctoral research in the Department of Microbiology at Kumamoto University School of Medicine, Kumamoto, Japan, where he investigated the molecular mechanisms of host defense function of nitric oxide during gastrointestinal infection caused by Salmonella Typhimurium.
Dr. Zaki did postdoctoral research at Kumamoto University and later in the laboratory of Thirumala-Devi Kanneganti, Ph.D., at St. Jude Children's Research Hospital in Memphis, Tenn. There, his research focused on the role of NOD-like receptors (NLRs) in inflammatory bowel diseases and colorectal cancer. He demonstrated how NLR family members, particularly NLRP3 and NLRP12, suppress intestinal inflammation and cancer and maintain intestinal homeostasis.