Faculty Investigative Pathology

Our diverse faculty members share a common goal of probing fundamental mechanisms of disease through basic and applied investigations. Dominant themes of research include cancer biology and immunology, with expertise in aging, DNA repair, developmental and reproductive biology, bioinformatics, and signal transduction. Labs are staffed by accomplished graduate and medical students, postdoctoral scholars, technical personnel, and physicians.

Highlights of our Investigative Pathology area include:

  • Ties between the labs are strengthened by an annual retreat, as well as bimonthly seminars including the departmental seminar series and a pathophysiology of disease seminar given by pathology residents
  • Wide array of departmental core facilities including molecular histology and flow cytometry 

Numerous opportunities exist for collaborations aimed at maximizing the interactions between basic scientists and physicians in the elucidation of mechanisms of disease. We invite you to explore the individual web pages of our investigative faculty.

James S. Malter, M.D.

Professor and Chair of Pathology

Research Interests: Post-transcriptional gene regulation and signaling in the immune and nervous system.

Malter Lab

Usha Avirneni, Ph.D.

Assistant Instructor

Research Interests: Member of the Galindo Lab.

Dennis K. Burns, M.D.

Professor

Research Interests: Neuromuscular pathology, electron microscopy, and the evaluation of phenotypic alterations in genetically engineered mouse models.

Kelley Carrick, M.D.

Associate Professor

Research Interests: Gynecologic pathology

Diego Castrillon, M.D., Ph.D.

Associate Professor

Director, Investigative Pathology

Research Interests: Understanding the molecular basis of reproduction and diseases of the reproductive tract, with an emphasis on the stem cells that drive these processes.

Castrillon Lab

Weina Chen, M.D., Ph.D.

Weina Chen, M.D., Ph.D.

Associate Professor

Director of Hematopathology

Co-Director of Flow Cytometry

Medical Director of Hematology and Bone Marrow Laboratory

Research Interests: Hematopathology, pathobiology of myeloid and lymphoid neoplasms, and flow cytometry

Ileana Cuevas, Ph.D.

Instructor

Research Interests: Member of the Castrillon Lab.

Errol Friedberg, M.D.

Professor Emeritus

Research Interests: Understanding the molecular mechanism of DNA repair and mutagenesis in eukaryotes and the roles of these processes in cancer associated with both spontaneous DNA damage and that caused by environmental carcinogens.

Friedberg Lab

Rene Galindo, M.D., Ph.D.

Assistant Professor

Associate Dean of Medical Student Research

Research Interests: Genetic and molecular underpinnings of childhood cancer. To address these issues, we are presently utilizing multiple animal model systems (including invertebrate and mammalian models) to dissect the biology of the most common soft-tissue sarcoma of childhood –- the skeletal muscle-type tumor rhabdomyosarcoma.

Galindo Lab

Rita Gander, Ph.D.

Professor

Research Interests: Evaluation of new diagnostic tests in clinical microbiology.

Adi Gazdar, M.D.

Professor

Research Interests: Long term goals of Dr. Gazdar’s research efforts are to determine the molecular and genetic basis of human cancers, and to develop molecular insights to provide prognostic and diagnostic therapies in the treatment of human cancers.

Gazdar Lab

Robert M. Genta, M.D.

Clinical Professor

Research Interests: Gastritis (Helicobacter pylori) and its associations, eosinophilic esophagitis and patho-epidemiologic studies based on analyses from large databases.

Ibrahim A. Hashim, M.Sc., Ph.D.

Professor

Chief of Clinical Pathology

Director of Clinical Chemistry

Research Interests: Elucidating the role of inflammatory cytokines and their mediators in the pathogenesis of heatstroke, trauma, and meningitis. I am also interested in proteomics and molecular heterogeneity of prolactin and of cytokines and on posttranslational modifications affecting their biological and immunological activities.

Kimmo Hatanpaa, M.D., Ph.D.

Associate Professor

Research Interests: Brain tumors and neuropathology.

Emily Herndon, M.D.

Faculty Associate

Research Interests: Study of Huntington disease, frontotemporal dementia, multiple sclerosis, autism spectrum disorders, and inflammatory myopathies.

Sarah Johnson-Welch, M.D.

Associate Professor

Director of Autopsy, Children’s Health℠ 

Research Interests: Perinatal and placental pathology and autopsy pathology.

Patricia Jones, Ph.D.

Professor

Director of Chemistry, Children’s Health℠ 

Research Interests: Inborn errors of metabolism, especially disorders of fatty acid metabolism.

Payal Kapur, M.D.

Associate Professor

Medical Director Surgical Pathology, Parkland Memorial Hospital

Group Leader, Genitourinary Pathology, UTSW

Kidney Cancer Program Co-Leader, Simmons Cancer Center

Research Interests: Adult genitourinary pathology.

Erik Knudsen, Ph.D.

Professor

Cheryl Lewis, Ph.D.

Assistant Professor

Director of Tissue Repository

Research Interests: Identifying biomarkers of DCIS progression, and studying gastrointestinal and liver pathology cancers using clinically annotated biospecimens.

Xiao-Yun Liu, Ph.D.

Instructor

Research Interests: Member of the Gazdar Lab.

Kyle Molberg, M.D.

Professor

Chief of Pathology Services, Parkland Memorial Hospital

Research Interests: General surgical pathology and urologic pathology.

Sara Monaghan, M.D.

Associate Professor

Research Interests: Translational studies involving myeloid neoplasms and plasma cell myeloma.

Yuji Nakada, Ph.D.

Instructor

Research Interests: Member of the Castrillon Lab.

Daniel Noland, M.D.

Assistant Professor

Director of Tissue and Transfusion Services, Children’s Health℠ 

Research Interests: Clinical and translation applications of therapeutic apheresis and pediatric transfusion medicine.

Dwight Oliver, M.D.

Associate Professor

Research Interests: Development of molecular diagnostic assays and their applications in oncology and infectious disease.

Steven Pakes, D.V.M., Ph.D.

Adjunct Professor

Research Interests: Development and elucidation of animal models for human diseases.

Jason Park, M.D., Ph.D.

Assistant Professor

Clinical Director of Advanced Diagnostics, Children’s Health℠ 

Research Interests: Development of clinical laboratory technologies with a focus on gastrointestinal and liver pathology and pediatric diseases.

Steven Patrie, Ph.D.

Assistant Professor

Research Interests: Proteomics, mass spectrometry, and protein array methods development; mechanisms in autoimmune/neurodegenerative disorders and cancer epigenetics.

Patrie Lab

Lan Peng, M.D.

Assistant Professor

Research Interests: Autoimmune hepatitis, acute liver failure, pancreatic neoplasm, inflammatory bowel disease.

Yan Peng, M.D., Ph.D.

Associate Professor

Research Interests: To explore prognostic and predictive tumor biomarkers for breast cancer by immunohistochemistry and molecular techniques.

Dinesh Rakheja, M.D.

Associate Professor

Chief of Pediatric Pathology, Children’s Health℠ 

Research Interests: Pediatric solid tumors

James Richardson, D.V.M., Ph.D.

Professor

Director of Sophomore Medical School Course

Research Interests: Analysis of murine phenotypes, comparative pathology, and developmental biology.

Richardson Lab/Molecular Pathology

Ravi Sarode, M.D.

Professor

Chief of Pathology and Medical Director, Clinical Laboratory Services

Research Interests: TTP platelet function disorders, HIT, management of anticoagulation related bleeding, thrombophilia, and patient blood management.

Venetia Sarode, M.D.

Associate Professor

Research Interests: Related to breast cancer biomarkers and the impact of neoadjuvant chemotherapy on biomarker expression and the biology of HER2-positive breast cancer.

Zhong-Jian Shen, M.D., Ph.D.

Instructor

Research Interests: Member of the Malter Lab.

Mark Siegelman, M.D., Ph.D.

Associate Professor

Research Interests: Molecular biology of cell surface molecules governing adhesion to and transmigration through vascular endothelium.

Siegleman/Estess Lab

Timothy Sliter, Ph.D.

Associate Professor

Research Interests: Molecular genetics of DNA polymorphisms of value in forensic evidence examinations.

Paul Southern, M.D.

Professor

Director of Microbiology, Parkland Memorial Hospital

Research Interests: Define the prevalence of infection due to Trypanosoma cruzi (Chagas disease) in the human population of the Toledo District of Belize.

Southern Lab

Jose Torrealba, M.D.

Associate Professor

Associate Director of Anatomic Pathology

Medical Director of Histology, IHC Laboratories, and Renal Pathology

Director of General Surgical Pathology – Zale Lipshy University Hospital

Research Interests: Immunopathology of solid organ transplantation; mechanisms involved in the development of chronic allograft injury, including alloimmunity, autoimmunity, and non-immune related allograft injury.

Charles White III, M.D.

Professor

Director of Neuropathology

Research Interests: Neurodegenerative diseases and forensic neuropathology

Agnes Witkiewicz, M.D.

Associate Professor

Director of Tissue Repository

Hasan Zaki, Ph.D.

Assistant Professor

Research Interests: NOD-like receptors, host-pathogen interaction, inflammatory bowel disease, and colorectal cancer

Ram Mani, Ph.D.

Assistant Professor

Research Interests: Epigenetic mechanisms underlying cancer progression, ETS gene fusions in prostate cancer, Genomic rearrangements in cancer, Transcriptional regulation in prostate cancer