Molecular Diagnostics Rotation

The Molecular Diagnostics rotation includes training in basic and advanced molecular biology techniques as applied to modern pathology. The resident will observe molecular diagnostic tests for hematopoietic malignancies, infectious diseases, solid tumors, pharmacogenomics, and inherited disorders.

During this rotation, the resident will have numerous interactions with the Director, including problem-based teaching on various aspects of Molecular Pathology, signing out results, and investigating unusual test results.

At the end of the rotation, the resident will be able to describe the various target-based and signal-based amplification methods and list the pros and cons for each method.

Additionally, the resident will diagram the workflow of a molecular diagnostic laboratory, list the possible pitfalls of molecular diagnostic tests, and be exposed to "real-time" PCR, molecular karyotyping, MLPA, clinical sequencing, array-based tests, and solid tumor theranostic tests.

The resident will also meet with the Translational Pathology faculty and learn about emerging technologies and approaches in modern pathology.

Faculty

Duration

One month

Prerequisites

None

Objectives

Conferences

  • Clinical Pathology Rounds
  • Update in Pathophysiology

Basic Reading

  • Color Atlas of Genetics by Passarge
  • Principles of Molecular Pathology by Killeen
  • Also includes the following links: