Faculty and Research Interests

Faculty with Primary Appointments in Neuroscience

Joseph Takahashi, Ph.D.EmailLab Website

Joseph Takahashi

The long-term goals of the Takahashi Laboratory are to understand the molecular and genetic basis of circadian rhythms in mammals and to use forward genetic approaches in the mouse as a tool for gene discovery for complex behavior.

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Carla Green, Ph.D.EmailLab Website

Carla Green

The Green Laboratory studies the molecular mechanisms by which the circadian clock controls rhythmic processes within the cell, with a particular focus on post-transcriptional regulatory mechanisms.

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Jay Gibson, Ph.D.EmailLab Website

Jay Gibson

Researchers in the Gibson Laboratory use electrophysiological methods to study neocortical circuit development and plasticity. Group members focus on how circuits are altered in the mouse model of fragile X Syndrome.

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Ryan Hibbs, Ph.D.EmailLab Website

Ryan Hibbs

The Hibbs Laboratory studies the mechanisms of ligand-gated ion channel function at the atomic scale, using biochemistry, electrophysiology, and X-ray crystallography.

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Kim Huber, Ph.D.EmailLab Website

Kim Huber

The Huber Laboratory studies mechanisms of synaptic plasticity that occur during development and in the adult. We focus on the role of local translation in synaptic plasticity, and how genes linked with human mental disorders affect these processes. We use a combination of electrophysiology, imaging and biochemistry.

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Jane Johnson, Ph.D.EmailLab Website

Jane Johnson

The Johnson Lab focuses on the function of neural bHLH transcription factors to probe molecular mechanisms that control the balance of neural progenitor cell maintenance and differentiation, and the generation of neuronal diversity, particularly in the spinal cord. Her group also uses those factors to study the generation of neural cancers such as glioblastoma and neuroendocrine lung carcinoma. 

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Ege Kavalali, Ph.D.EmailLab Website

Ege Kavalali

Dr. Kavalali studies mechanisms of neurotransmission and synaptic signaling in the central nervous system. His group examines the molecular basis and functional consequences of heterogeneity among synaptic vesicle recycling pathways present within individual synapses.

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Tae-Kyung (TK) Kim, Ph.D.EmailLab Website

TK Kim

The Kim Laboratory studies how sensory stimulation can be accurately translated into cellular and behavioral plasticity through genetic and epigenetic mechanisms. We focus on the role of various types of long non-coding RNAs in brain development and function, and neuronal activity-regulated epigenetic mechanisms underlying cognitive diseases.

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Gena Konopka, Ph.D.EmailLab Website

Gena Konopka

The Konopka Laboratory uses a combination of functional genomics, animal and human cellular modeling, and evolutionary comparisons. Her group's goal is to identify genes and molecular pathways that enhance cognitive function in the human brain, and whose dysfunction may play a role in disorders such as autism and schizophrenia.

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Helmut Krämer, Ph.D.EmailLab Website

Helmut Krämer

The Krämer Laboratory uses Drosophila genetics to study the pathways that regulate the delivery of cargo from endosomes, phagosomes, and autophagosomes to lysosomes. His group also seeks to understand the role of glia cells in visual neurotransmission.

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Weichun Lin, Ph.D.EmailLab Website

Weichun Lin

The Lin Laboratory uses the vertebrate neuromuscular junction as a model to study synaptic biology. Our current research focuses on determining (1) how signals from the muscle regulate the differentiation of the motor nerve terminals, and (2) the contribution of myogenic activity to the maintenance of the synapses. Our techniques include mouse genetics, electrophysiology, electron microscopy, biochemistry, and molecular biology.

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Julian Meeks, Ph.D.EmailLab Website

Julian Meeks

The Meeks Laboratory studies the neural mechanisms underlying pheromone-mediated social and reproductive behaviors in mice. Our research focuses on synaptic interactions between excitatory and inhibitory neurons in the accessory olfactory bulb, and how those interactions sculpt information flowing through this circuit.

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Lisa Monteggia, Ph.D.EmailLab Website

Lisa Monteggia

Dr. Monteggia studies molecular and synaptic mechanisms underlying neurodevelopmental disorders, as well as mechanisms of antidepressant action in the central nervous system. Her group focuses on the role of epigenetic factors in autism spectrum disorders, and also investigates the molecular basis of novel, fast-acting antidepressants.

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Todd Roberts, Ph.D. • Email • Lab Website

Todd Roberts

The Roberts Lab studies the circuit and cellular mechanisms for vocal learning, how the brain encodes long-term memories during social interactions and uses auditory feedback to shape vocal behaviors. We are identifying the neural circuit mechanisms engaged as juvenile songbirds learn to imitate their father’s song using two-photon imaging, optogenetics, and electrophysiological approaches.

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Dean Smith, M.D., Ph.D.EmailLab Website

Dean Smith

The Smith Lab explores the mechanisms mediating volatile pheromone signaling in Drosophila. Image: localization of a lipid flippase required for normal pheromone sensitivity in the dendrites of a subset of olfactory neurons in the antenna.

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Jonathan Terman, Ph.D.EmailLab Website

Jonathan Terman

The Terman Lab explores the cellular, molecular, and biochemical mechanisms underlying cellular process formation, extension, and navigation. We are particularly interested in how axons, the cellular processes of neurons, find their targets and can be encouraged to regrow following injury or disease.

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Shin Yamazaki, Ph.D.EmailLab Website

Shin Yamazaki

The Yamazaki Laboratory studies circadian pacemaker structures that control feeding and locomotor activity rhythms as well as in vivo and environmental factors that influence circadian organization.

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Gang Yu, Ph.D.EmailLab Website

Gang Yu

The Yu Laboratory studies the molecular and cellular basis of Alzheimer’s and related diseases. We use biophysics, biochemistry, and cell biology to understand the inner workings of the gamma-secretase complex.

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Faculty with Secondary Appointments in Neuroscience

Woo-Ping Ge, Ph.D.Email • Lab Website

Woo-Ping Ge

The Ge Laboratory studies the interactions between the brain vasculature and the nervous system: how a brain builds the gliovascular and neurovascular network during development, how this network is damaged during strokes, and how the network is repaired after strokes.

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Joachim Herz, M.D.EmailLab Website

Joachim Herz

The Herz Lab studies the molecular basis of Alzheimer’s disease and frontotemporal dementia. We specifically investigate how disruption of endosomal trafficking by Apolipoprotein E4 affects the synapse and how progranulin deficiency leads to lysosomal dysfunction, and then apply these insights to drug discovery.

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Adjunct Faculty

Thomas Südhof, M.D. • Lab Website

Thomas

Thomas Südhof, M.D., now at Stanford University School of Medicine, is a leader in research on nerve cell interaction and neurotransmitter release during normal and pathological brain function. His work on the machinery regulating vesicle transport in synaptic transmission led to his receiving the 2013 Nobel Prize in Physiology or Medicine. Dr. Südhof spent 25 years at UT Southwestern from 1983 to 2008. He retains his association as Adjunct Faculty in the Department of Neuroscience.

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