Lipodystrophy Therapies

Cosmetic disfigurement due to fat loss is a major cause of concern for patients. Besides fat loss and excessive muscular appearance and hirsutism (increased body hair), dark color pigmentation and thickening of the skin in the neck, armpits, groin, and the trunk due to acanthosis nigricans may pose cosmetic problems.

Diabetes is usually severe, and may produce short and long-term complications such as kidney disease, retinal (eye) disease, heart disease, and neuropathy (nerve damage).

Hypertriglyceridemia (high levels of blood fats) may cause acute pancreatitis (acute pancreatic injury with severe abdominal pain) and can potentially further contribute to early-onset coronary heart disease.

Cosmetic Management

Several surgical methods have been used including facial reconstruction with transplanted tissue flaps, transposition of facial muscles, facial implants, and collagen injections in the cheeks, however the results are variable. Liposuction and lipectomy for removal of excessive facial or neck fat have been carried out in several patients with familial partial lipodystrophies. The decision to undergo any such modes of treatment must be undertaken with the advice of the physician. Areas of excess fat accumulation may reduce with weight loss.

Diet

Low-fat diet is advised for patients with hypertriglyceridemia. Regular exercise and weight loss may reduce the chances of developing diabetes and dyslipidemia and are useful when these conditions are established. Children with lipodystrophies should be allowed to consume adequate calories to allow for proper growth and nutrition.

Therapy for Diabetes

The efficacy of various drugs such as sulfonylureas (glyburide, glipizide), biguanides (metformin) ,and thiazolidinediones (rosiglitazone, pioglitazone) has not systematically been investigated, although they have been used to control blood glucose levels in patients with lipodystrophies. Insulin is commonly given to control hyperglycemia. Extremely high doses of insulin are often required to control levels of blood glucose. In such cases, concentrated preparation of insulin containing 500 units/mL can be helpful.

Therapy for High Blood Cholesterol and Triglycerides

Patients with extreme high blood triglyceride levels should be treated with fibrates (gemfibrozil, clofibrate, benzafibrate, fenofibrate) and omega-3 polyunsaturated fatty acids (omega-3 fatty acids) from fish oils. Occasionally patients may require a combination of drugs including fibrates and statins (Lovastatin, simvastatin, atorvastatin, etc.), however, risk of muscle toxicity may limit their use. Niacin should be avoided since it may exacerbate hyperglycemia. Oral contraceptives and postmenopausal hormone replacement therapy should be avoided in females as the estrogens in these preparations may increase the blood level of triglycerides.

Management of Lipodystrophies in HIV-Infected Patients

General principles of dietary therapy remain as above. Aerobic exercise should be encouraged to improve hyperlipidemia. Exercise and the dietary restriction can also reduce excess abdominal fat. General principles of drug therapy of hyperlipidemia remain as above. However, most of the lipid-lowering drugs have potential for interaction with antiretroviral drugs and may produce adverse reactions. Diabetes is usually managed with oral drugs as appropriate.

Cessation and Alterations of Antiretroviral Therapies

Withdrawal of protease inhibitors (PIs, a class of anti-HIV medication) from the therapy or switching of PIs with other anti-retroviral drugs may result in the improvement of fat loss and in lipid profile. Many clinical trials of "switch therapy" assessing the benefits and problems are currently underway. However, this decision should be made carefully, since there is a chance that HIV-infection may not remain controlled.

Recombinant Human Growth Hormone (rhGH)

Therapy with rhGH has been reported to cause reduction in the size of 'buffalo hump' and truncal fat in a small number of patients. However, fat loss and lipid abnormalities did not improve and blood glucose control worsened.

Anabolic Steroids (Testosterone, Oxandrolone)

These medications have previously been used to treat AIDS wasting syndrome, which is different than HIV-associated lipodystrophy. Anabolic steroids may lessen intra-abdominal fat, but there will likely be a worsening of blood cholesterol and triglyceride levels in addition to worsened glucose control.