Recent Publications

Basic Research Related to Inflammation and Injury

Bartuzi P, Wijshake T, Dekker DC, Fedoseienko A, Kloosterhuis NJ, Youssef SA, Li H, Shiri-Sverdlov R, Kuivenhoven JA, de Bruin A, Burstein E, Hofker MH, van de Sluis B. (2014) A cell-type-specific role for murine Commd1 in liver inflammation. Biochim Biophys Acta. Nov;1842(11):2257-65. PMID: 2507258.

Li H, Chan L, Bartuzi P, Melton SD, Weber A, Ben-Shlomo S, Varol C, Raetz M, Mao X, Starokadomskyy P, van Sommeren S, Mokadem M, Schneider H, Weisberg R, Westra HJ, Esko T, Metspalu A, Kumar V, Faubion WA, Yarovinsky F, Hofker M, Wijmenga C, Kracht M, Franke L, Aguirre V, Weersma RK, Gluck N, van de Sluis B, Burstein E. (2014) Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer. Gastroenterology. Jul;147(1):184-195. PMID:  24727021.

Raetz M, Kibardin A, Sturge CR, Pifer R, Li H, Burstein E, Ozato K, Larin S, Yarovinsky F. (2013) Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin. J Immunol. Nov 1;191(9):4818-27. PMID: 24078692.

Starokadomskyy P, Gluck N, Li H, Chen B, Wallis M, Maine GN, Mao X, Zaidi IW, Hein MY, McDonald FJ, Lenzner S, Zecha A, Ropers HH, Kuss AW, McGaughran J, Gecz J, Burstein E. (2013) CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling. J Clin Invest. May 1;123(5):2244-56. PMID: 23563313.

Colleran A, Collins PE, O'Carroll C, Ahmed A, Mao X, McManus B, Kiely PA, Burstein E, Carmody RJ. (2013) Deubiquitination of NF-κB by Ubiquitin-Specific Protease-7 promotes transcription. Proc Natl Acad Sci U S A. Jan 8;110(2):618-23. PMID: 23267096.

Ziesché E, Kettner-Buhrow D, Weber A, Wittwer T, Jurida L, Soelch J, Müller H, Newel D, Kronich P, Schneider H, Dittrich-Breiholz O, Bhaskara S, Hiebert SW, Hottiger MO, Li H, Burstein E, Schmitz ML, Kracht M. (2013) The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB. Nucleic Acids Res. Jan 7;41(1):90-109. PMID: 23087373.

Basic Research Related to Metabolism

Aqul A, Lopez AM, Posey KS, Taylor AM, Repa JJ, Burns DK, Turley SD. (2014)  Hepatic entrapment of esterified cholesterol drives continual expansion of whole-body sterol pool in lysosomal acid lipase-deficient mice.  Am J Physiol Gastrointest Liver Physiol. Oct 15;307(8):G836-47. PMID: 25147230.

Lopez AM, Terpack SJ, Posey KS, Liu B, Ramirez CM, Turley SD. (2014)  Systemic administration of 2-hydroxypropyl-β-cyclodextrin to symptomatic Npc1-deficient mice slows cholesterol sequestration in the major organs and improves liver function. Clin Exp Pharmacol Physiol. Oct;41(10):780-7. PMID: 25115571.

Mundy DI, Lopez AM, Posey KS, Chuang JC, Ramirez CM, Scherer PE, Turley SD. (2014) Impact of the loss of caveolin-1 on lung mass and cholesterol metabolism in mice with and  without the lysosomal cholesterol transporter, Niemann-Pick type C1. Biochim Biophys Acta. Jul;1841(7):995-1002. PMID: 24747682.

Chuang JC, Valasek MA, Lopez AM, Posey KS, Repa JJ, Turley SD. (2014) Sustained and selective suppression of intestinal cholesterol synthesis by Ro 48-8071, an inhibitor of 2,3-oxidosqualene:lanosterol cyclase, in the BALB/c mouse. Biochem Pharmacol.  Apr 1;88(3):351-63. PMID: 24486573.

Ramirez CM, Lopez AM, Le LQ, Posey KS, Weinberg AG, Turley SD. (2014)
Ontogenic changes in lung cholesterol metabolism, lipid content, and histology in mice with Niemann-Pick type C disease. Biochim Biophys Acta. Jan;1841(1):54-61. PMID: 24076310.

Moon YA, Ochoa CR, Mitsche MA, Hammer RE, Horton JD. (2014) Deletion of ELOVL6 Blocks the Synthesis of Oleic Acid but does not Prevent the Development of Fatty Liver or Insulin Resistance. J Lipid Res. Dec;55(12):2597-605. PMID: 25281760.

Duarte JA, Carvalho F, Pearson M, Horton JD, Browning JD, Jones JG, Burgess SC. (2014)  A HFD suppresses de novo lipogenesis and desaturation, but not elongation and triglyceride synthesis in mice. J Lipid Res. Dec;55(12):2541-53. PMID:  25271296.

Xu M, Nagati JS, Xie J, Li J, Walters H, Moon YA, Gerard RD, Huang CL, Comerford SA, Hammer RE, Horton JD, Chen R, Garcia JA. (2014) An acetate switch regulates stress erythropoiesis. Nat Med. Sep;20(9):1018-26. PMID: 25108527.

Sankella S, Garg A, Horton JD, Agarwal AK  (2014) Hepatic gluconeogenesis is enhanced by phosphatidic acid which remains uninhibited by insulin in lipodystrophic Agpat2-/- mice. J Biol Chem. Feb 21;289(8):4762-77. PMID: 24425876.

Cortés VA, Cautivo KM, Rong S, Garg A, Horton JD, Agarwal AK. (2014) Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors. J Lipid Res. Feb;55(2):276-88. PMID: 24293639.

Fitzgerald K, Frank-Kamenetsky M, Shulga-Morskaya S, Liebow A, Bettencourt BR, Sutherland JE, Hutabarat RM, Clausen VA, Karsten V, Cehelsky J, Nochur SV, Kotelianski V, Horton J, Mant T, Chiesa J, Ritter J, Munisamy M, Vaishnaw AK, Gollob JA, Simon A. (2014) Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial. Lancet. Jan 4;383(9911):60-8. PMID: 24094767.

Fabbrini E, Higgins PB, Magkos F, Bastarrachea RA, Voruganti VS, Comuzzie AG, Shade RE, Gastaldelli A, Horton JD, Omodei D, Patterson BW, Klein S. (2013)  Metabolic response to high-carbohydrate and low-carbohydrate meals in a nonhuman primate model. Am J Physiol Endocrinol Metab. Feb 15;304(4):E444-51. PMID: 23269412. 

Ding B, Wang W, Selvakumar T, Xi HS, Zhu H, Chow CW, Horton JD, Gronostajski RM, Kilpatrick RM. (2013). Temporal regulation of nuclear factor one occupancy by calcineurin/NFAT governs a voltage-sensitive developmental switch in late maturing neurons. J Neurosci. Feb 13;33(7):2860-72. PMID: 23407945.

Deng Y, Wang ZV, Tao C, Gao N, Holland WL, Ferdous A, Repa JJ, Liang G, Ye J, Lehrman MA, Hill JA, Horton JD, Scherer PE. (2013) The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism. Jan 2;123(1):455-68. PMID: 23257357.

Clinical Research Related to Upper GI

Dunbar KB, Spechler SJ: (2014) Controversies in Barrett esophagus. Mayo Clinic proceedings. Jul;89(7):973-84. PMID: 24867396.

Dunbar KB: (2013) Endoscopic eradication therapy for mucosal neoplasia in Barrett's esophagus. Current opinion in gastroenterology, Jul;29(4):446-53. PMID: 23703368.

Dunbar KB: (2013) Endomicroscopy in Barrett's esophagus. Gastrointestinal endoscopy clinics of North America. Jul;23(3):565-79. PMID: 23735103.

Clinical Research Related to Endoscopy and Imaging

Ahmed A, Bailey A, Agrawal D. (2014) Unusual complication of endoscopic cystogastrostomy.
Gastroenterology. May;146(5). PMID: 24681175.

Agrawal D, Rockey DC. (2013) Sterile water in endoscopy: habit, opinion, or evidence.
Gastrointest Endosc. Jul;78(1):150-2. PMID: 23570621.

Clinical Research Related to Colon Cancer

Tian C, Champlin S, Mackert M, Lazard A, Agrawal D. (2014) Readability, suitability, and health content assessment of web-based patient education materials on colorectal cancer screening. Gastrointest Endosc. Aug;80(2):284-90. PMID: 24674352.

Agrawal D, Rockey DC. (2013) Propofol for screening colonoscopy in low-risk patients: are we paying too much? JAMA Intern Med. Oct 28;173(19):1836-8. PMID: 23857456.

Clinical Research Related to Liver Diseases

Rahimi RS, Singal AG, Cuthbert JA, Rockey DC. (2014) Lactulose vs Polyethylene Glycol 3350-Electrolyte Solution for Treatment of Overt Hepatic Encephalopathy: The HELP Randomized Clinical Trial. JAMA Intern Med. Nov 1;174(11):1727-33. PMID: 25243839.

Hashim IA, Cuthbert JA (2014) Elevated ammonia concentrations: Potential for pre-analytical and analytical contributing factors. Clin Biochem. Nov;47(16-17):233-6. PMID: 25175939.

Hashim IA, Cuthbert JA. (2014)Establishing, harmonizing and analyzing critical values in a large academic health center. Clin Chem Lab Med. Aug;52(8):1129-35. PMID: 24622791.

Cuthbert JA, Arslanlar S, Yepuri J, Montrose M, Ahn CW, Shah JP. (2014) Predicting short-term mortality and long-term survival for hospitalized US patients with alcoholic hepatitis. Dig Dis Sci. Jul;59(7):1594-602. PMID: 24445730.

Singal AG, Li X, Tiro J, Kandunoori P, Adams-Huet B, Nehra MS, Yopp A: (2014) Racial, Social, and Clinical Determinants of Hepatocellular Carcinoma Surveillance. The American journal of medicine. Jan;128(1):90. PMID: 25116425.

Dalton-Fitzgerald E, Tiro J, Kandunoori P, Halm EA, Yopp A, Singal AG: (2014) Practice Patterns and Attitudes of Primary Care Providers and Barriers to Surveillance of Hepatocellular Carcinoma in Patients With Cirrhosis. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association. Jul 11. pii: S1542-3565(14)00987-2. PMID: 25019694.

Gopal P, Yopp AC, Waljee AK, Chiang J, Nehra M, Kandunoori P, Singal AG: (2014) Factors that affect accuracy of α-fetoprotein test in detection of hepatocellular carcinoma in patients with cirrhosis. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association. May;12(5):870-7. PMID: 24095974.

Salgia RJ, Singal AG, Fu S, Pelletier S, Marrero JA: (2014) Improved post-transplant survival in the United States for patients with cholangiocarcinoma after 2000. Digestive diseases and sciences, May;59(5):1048-54. PMID: 23504331.

Singal AG, Pillai A, Tiro J: (2014) Early detection, curative treatment, and survival rates for hepatocellular carcinoma surveillance in patients with cirrhosis: a meta-analysis. PLoS medicine, Apr 1;11(4):e1001624. PMID: 24691105.

Yopp AC, Mansour JC, Beg MS, Arenas J, Trimmer C, Reddick M, Pedrosa I, Khatri G, Yakoo T, Meyer JJ, Shaw J, Marrero J, Singal AG et al: (2014) Establishment of a multidisciplinary hepatocellular carcinoma clinic is associated with improved clinical outcome. Annals of surgical oncology. Apr;21(4):1287-95. PMID: 24318095.

Singal AG, Marrero JA, Yopp A: (2014) Screening process failures for hepatocellular carcinoma. Journal of the National Comprehensive Cancer Network : JNCCN, Mar 1;12(3):375-82  PMID: 24616543.

Singal AG, Manjunath H, Yopp AC, Beg MS, Marrero JA, Gopal P, Waljee AK: (2014) The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis. The American journal of gastroenterology, Mar;109(3):325-34. PMID: 24445574.

Singal AG, Mukherjee A, Elmunzer BJ, Higgins PD, Lok AS, Zhu J, Marrero JA, Waljee AK: (2013) Machine learning algorithms outperform conventional regression models in predicting development of hepatocellular carcinoma. The American journal of gastroenterology,  Nov;108(11):1723-30. PMID: 24169273.

Tan D, Yopp A, Beg MS, Gopal P, Singal AG: (2013)  Meta-analysis: underutilisation and disparities of treatment among patients with hepatocellular carcinoma in the United States. Alimentary pharmacology & therapeutics, Oct;38(7):703-12. PMID: 23957569.

Singal AG, Rahimi RS, Clark C, Ma Y, Cuthbert JA, Rockey DC, Amarasingham R: (2013) An automated model using electronic medical record data identifies patients with cirrhosis at high risk for readmission. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association, Oct;11(10):1335-1341. PMID: 23591286.

Singal AG, Dharia TD, Malet PF, Alqahtani S, Zhang S, Cuthbert JA: (2013) Long-term benefit of hepatitis C therapy in a safety net hospital system: a cross-sectional study with median 5-year follow-up. BMJ open, Sep 3;3(9).  PMID: 24002983.

Singal AG, Waljee AK, Patel N, Chen EY, Tiro JA, Marrero JA, Yopp AC: (2013) Therapeutic delays lead to worse survival among patients with hepatocellular carcinoma. Journal of the National Comprehensive