Center for Autophagy Research: Faculty
Autophagy in Cell Death Regulation and Cancer Biology
Autophagy in Innate Immunity against Intracellular Pathogens
The Zhong lab studies the biochemical mechnaism of mammalian autophagy, including PI3P production, membrane curvature sensing, cargo recruitment, and membrane tethering/fusion.
The Ball Protein Chemistry Technology Center provides advanced peptide synthesis, MALDI mass spectrometry and Edman sequencing services, for a fee or through a collaborative arrangement.
Autophagy and Cancer Biology
Autophagy and Cell Death Regulation
We study how autophagy is activated during viral infection (i.e. Virophagy) and how virophagy functions to restrict the replication of some viruses. We utilize an image-based genome-wide siRNA screen approach and genetic and biochemical approaches to identify and characterize host virophagy factors. Unraveling the molecular mechanisms of virology will enhance our understanding of the interplay between host and viruses, as well as potentially identify additional targets that can be used to therapeutically modulate autophagy in the treatment of viral diseases.
My work is focused on investigating selective autophagy as a novel pathway of host innate immunity. I am exploring the role of newly identified selective autophagy factors in host defense against viruses, in the removal of damaged mitochondria, and in the regulation of proinflammatory cytokine production.