Green Center Members and Labs

The Green Center consists of members from the Department of Obstetrics and Gynecology, as well as about 20 additional members from a variety of other departments on the North and South campuses.

The Director, W. Lee Kraus, Ph.D., is located on the 7th floor of the Moss (J) Building. The new faculty hires will also be located there. Drs. Halvorson, Mahendroo, and Word (Department of Obstetrics and Gynecology) are located on the 2nd floor of the Cary (F) Building. Dr. Mendelson (Biochemistry) is located on the 3rd floor of the Jonsson (K) Building.

Green Center Members

W. Lee Kraus, PhD, Director of the Green  Center.
W. Lee Kraus, Ph.D., Director of the Green Center.

W. Lee Kraus, Ph.D.
Director
Green Center
Department of Obstetrics and Gynecology
Laboratory: Kraus Research Laboratory
lee.kraus@utsouthwestern.edu

Research: Mechanisms of nuclear signaling and gene regulation by small molecules and the relationship of these signaling pathways to human diseases. Our focus is on two distinct, but probably related, nuclear signaling pathways controlled by estrogens and NAD.

Xiaoying Bai, Ph.D.
Obstetrics and Gynecology
xiaoying.bai@utsouthwestern.edu  

Research: Using zebrafish as a genetic and developmental model in combination with mammalian systems to study transcriptional mechanisms that regulate the differentiation of hematopoietic stem cells, focusing on the interplay between different transcriptional phases. She will also study the epigenetic regulation affecting the Pol II elongation through chromatin and identify novel pathways interacting with the elongation machinery.

Bruce Carr, M.D.
Division of REI/Department of Obstetrics and Gynecology
bruce.carr@utsouthwestern.edu

Research: Regulation of Steroidogensis in the ovary, adrenal and placenta. Specifically, the regulation of CYP 17 expression. In addition, conducting clinical trials of women with endometriosis, uterine leiomyoma, infertility, and fertility control.

Diego Castrillon, M.D., Ph.D.
Pathology
Laboratory: Castrillon Research Lab
diego.castrillon@utsouthwestern.edu

Research: The Castrillon laboratory has broad interests in the intersection of reproduction, infertility, and cancer. Areas of special interest include P13K/Foxo signaling in the control and preservation of the gemline and the role of the LKB1/MTOR pathway in diverse cancers of the reproductive tract.

Cheng-Ming Chiang, Ph.D.
Cancer Center/Pathology
Laboratory: Chiang Laboratory
cheng-ming.chiang@utsouthwestern.edu

Research: Epigenetic control of gene regulation, mechanisms of transcriptional regulation in mammalian cells and in human papillomaviruses, and posttranslational modification of protein function.

Joel Elmquist, D.V.M., Ph.D.
Internal Medicine/Hypothalamic Research
Laboratory: Elmquist Lab
joel.elmquist@utsouthwestern.edu

Research: Dr. Elmquist's research focuses on identifying the pathways in the brain regulating body weight and glucose homeostasis. Toward these goals, Dr. Elmquist and colleagues have developed several mouse models that allow specific manipulation of key genes regulating energy balance and glucose homeostasis.

F. Kent Hamra, Ph.D.
Pharmacology
Laboratory: Hamra Lab
kent.hamra@utsouthwestern.edu

Research: Research in our laboratory is based on the biology and applications of sperm cells (i.e. spermatogonial cells). Spermatogonial stem cells function physiologically as germline stem cells in the testis by continuously renewing developing spermatozoa during the reproductive life of males. By nature, this links our investigations in pharmacology to several general scientific fields, in particular, reproductive biology, developmental biology, and genetics.

Bethany Janowski, Ph.D.
Pharmacology
bethany.janowski@utsouthwestern.edu

Research: Our lab is interested in understanding how duplex RNAs target non-coding RNA transcripts that overlap the PR locus and either silence or activate gene expression. We have applied this capability to other target genes to further study the mechanism and to study the biological consequences of altering expression of endogenous genes inside cells.

Ralf Kittler, Ph.D.
Eugene McDermott Center for Growth and Development
Laboratory: Kittler Lab
ralf.kittler@utsouthwestern.edu

Research: Cancer genomics. The Kittler lab is studying cancer-specific genetic programs, which are key for the development of new diagnostic, prognostic, and therapeutic strategies. We combine analyses of the genomic binding sites (ChIP-Seq) of cancer-relevant transcription factors, epigenetic, gene expression, and clinical outcome data to make specific predictions about the role of transcription factors and functional interaction of multiple transcription factors in the regulation of cancer-relevant gene networks.

Xin Liu, Ph.D.
Obstetrics and Gynecology, Biophysics 
xin.liu@utsouthwestern.edu

Research: Using structural biology to study the molecular mechanisms of pRb inactivation by a viral oncoprotein, the structural basis of protein acetylation by p300/CBP, and the mechanisms of transcriptional initiation by RNA polymerase II and associated factors. He will address the molecular mechanisms of start site selection for RNA polymerase II. In parallel, he will explore the RNA polymerase II transcription in the context of the three-dimensional structure of the genome, focusing on transcription-dependent gene looping. 

Mala Mahendroo, Ph.D.
Obstetrics and Gynecology
Laboratory: Mahendroo Laboratory
mala.mahendroo@utsouthwestern.edu

Research: My research interests include an understanding of the molecular mechanisms by which the cervix remodels during pregnancy, parturition and postpartum to allow birth and subsequent recovery of the cervix to the nonpregnant state. Our focus is on understanding the contribution of the extracellular matrix, immune cells, and cervical cells to this process and their regulation during all phases of cervical remodeling.

David Mangelsdorf, Ph.D.
Pharmacology
Laboratory: Mangelsdorf-Kliewer Lab
davo.mango@utsouthwestern.edu

Research: The Mangelsdorf/Kliewer lab studies nuclear receptor regulation of metabolism and cancer. Recent studies have elucidated two endocrine signaling pathways mediated by fibroblast growth factors that govern fasting and feeding.

Carole Mendelson, Ph.D.
Biochemistry, Obstetrics and Gynecology
Laboratory: Mendelson Laboratory
carole.mendelson@utsouthwestern.edu

Research: Genetic and epigenetic mechanisms that mediate expression of specific genes in a tissue- and cell-specific manner, that activate gene expression at distinct phases of embryonic development, and modulate their expression by hormones and second messengers.

Yunsun Nam, Ph.D.
Laboratory: Nam Lab
yunsun.nam@utsouthwestern.edu 

Research: Mechanisms of non-coding RNAs and their role in gene regulation important for development and cancer. A major focus  is the molecular mechanism and regulation of microRNA processing. The long-term goal is not only to elucidate how ncRNAs work but also to identify new avenues for developing therapeutics.

Eric Olson, Ph.D.
Molecular Biology
Laboratory: Olson Lab
eric.olson@utsouthwestern.edu

Research: Our lab studies muscle cells as a model for understanding how embryonic cells adopt specific fates, and how programs of cell differentiation and morphogenesis are controlled during development. We have focused on discovering novel transcription factors and extracellular signals, as well as novel transcription factors that control development of these muscle cell types and remodeling in response to cardiovascular and neuromuscular diseases.

Charles Rosenfeld, M.D.
Pediatrics, Obstetrics and Gynecology, Anesthesiology
charles.rosenfeld@utsouthwestern.edu

Research: My lab is interested in establishing the mechanisms that contribute to the regulation of uteroplacental and fetal umbilical blood flows during pregnancy, in particular estrogens, K channels, and angiotensin II, and how they are modified in disease states such as maternal hypertension and diabetes. We are also interested in understanding vascular smooth muscle development, how that contributes to prenatal and postnatal blood pressure regulation, and how alterations in fetal growth and development alter subsequent blood pressure regulation in infancy, childhood, and the adult.

Philip Shaul, M.D.
Pediatrics
Laboratory: Shaul-Mineo-Umetani Lab
philip.shaul@utsouthwestern.edu

Research: Our lab is primarily engaged in endothelial cell biology. Our overall goal is to identify the molecular components, the protein-protein interactions, the regulatory events occurring within signaling modules on the plasma membrane which dictate endothelial cell phenotype, and the propensity for vascular disease. Investigations are performed in cell culture models and in both in vitro and in vivo reconstitution systems in genetically modified mice.

Clifford Wai, M.D.
Division of Urogynecology, Department of Obstetrics and Gynecology
Laboratory: Wai Laboratory
clifford.wai@utsouthwestern.edu

Research: Animal models for lower urinary tract dysfunction and anal incontinence. More recently, interests have included exploring the role of mechanical trauma, denervation, pregnancy, and the effects of growth factors and myogenic stem cells on wound healing of the external anal sphincter. Other research interests include urogynecology education, functional anatomy and biomechanics of gynecologic surgical procedures, patient outcomes in incontinence, and pelvic organ prolapse.

Yihong Wan, Ph.D.
Pharmacology
Laboratory: Laboratory of Yihong Wan
yihong.wan@utsouthwestern.edu

Research: Our long term goal is to understand how the nuclear receptor family of transcription factors and associated pathways regulate development, metabolism, and cancer, using the skeleton and the mammary gland as model systems.

Michael White, Ph.D.
Cell Biology
Laboratory: White (Michael) Lab
michael.white@utsouthwestern.edu

Research: Mechanisms of cell regulation. Cancer cell biology. Drug target discovery and development.

Ann Word, M.D.
Obstetrics and Gynecology
Laboratory: Word Laboratory
ann.word@utsouthwestern.edu

Research: Mechanisms of extracellular matrix remodeling of the female reproductive tract in both physiologic states (e.g., during pregnancy, parturition, and the puerperium) and pathologic conditions (pelvic organ prolapse, urinary incontinence, and injury of the external anal sphincter)..

Jiang Wu, Ph.D.
Physiology
Laboratory: Jiang Wu Lab
jiang9.wu@utsouthwestern.edu

Research: We are interested in chromatin regulation of signaling pathways that are important for stem cell self-renewal and differentiation. The current focus is the function of ATP-dependent chromatin remodeling complexes in embryonic and neural development.

Andrew Zinn, M.D., Ph.D.
Internal Medicine/Eugene McDermott Center for Growth and Development
Laboratory: Zinn Laboratory
andrew.zinn@utsouthwestern.edu

Research: Genetic disorders of human growth, development, and reproduction, with emphasis on obesity and sex chromosome abnormalities.