Green Center Faculty

The Green Center consists of eight faculty members from the Department of Obstetrics and Gynecology, as well as more than 20 additional members from a variety of other departments across campus.

Our faculty work in wide areas related to reproductive biology, gene regulation, genomics, stem cells, RNA biology, structural biology, and biochemistry.

Core Green Center Faculty

Affiliated Members

Research Focus Areas and Other UTSW Faculty


Core Green Center Faculty

Xiaoying Bai, Ph.D.
Obstetrics and Gynecology
xiaoying.bai@utsouthwestern.edu

Research: Using zebrafish as a genetic and developmental model in combination with mammalian systems to study transcriptional mechanisms that regulate the differentiation of hematopoietic stem cells, focusing on the interplay between different transcriptional phases. She will also study the epigenetic regulation affecting the Pol II elongation through chromatin and identify novel pathways interacting with the elongation machinery.

Laura Banaszynski, Ph.D.
Obstetrics and Gynecology
Laboratory: Banaszynski Lab
laura.banaszynski@utsouthwestern.edu

Research: Dr. Banaszynski studies epigenetic contributions to gene expression and genome stability in mammalian systems. Her research focuses on the dynamic regulation of chromatin states at both coding and non-coding regions including the influence of histone variant incorporation on histone post-translational modification states. Her long-term goal is to improve our understanding of the chromatin-based mechanisms regulating fundamental cell-fate decisions in pluripotency and differentiation that are essential to our understanding of developmental processes.

Gary Hon, Ph.D.
Obstetrics and Gynecology
Laboratory: Hon Lab
gary.hon@utsouthwestern.edu

Research: Our primary research interest is to develop a comprehensive understanding of how the millions of non-coding regulatory elements encoded in our genomes precisely coordinate gene expression in developmental and disease contexts. A major focus is elucidating how genetic and epigenetic dysregulation of transcriptional enhancers supports a cancer cell’s altered transcriptional program. To accomplish this, we take a systems biology approach: developing and employing integrative techniques at the interface of gene regulation, epigenetics, functional genomics, and bioinformatics.

W. Lee Kraus, Ph.D.
Obstetrics and Gynecology
Laboratory: Kraus Research Laboratory
lee.kraus@utsouthwestern.edu

Research: Mechanisms of nuclear signaling and gene regulation by small molecules and the relationship of these signaling pathways to human diseases. Our focus is on two distinct, but probably related, nuclear signaling pathways controlled by estrogens and NAD.

Xin Liu, Ph.D.
Obstetrics and Gynecology, Biophysics
Laboratory: Liu Lab
xin.liu@utsouthwestern.edu

Research: Using structural biology to study the molecular mechanisms of pRb inactivation by a viral oncoprotein, the structural basis of protein acetylation by p300/CBP, and the mechanisms of transcriptional initiation by RNA polymerase II and associated factors. He will address the molecular mechanisms of start site selection for RNA polymerase II. In parallel, he will explore the RNA polymerase II transcription in the context of the three-dimensional structure of the genome, focusing on transcription-dependent gene looping.

Mala Mahendroo, Ph.D.
Obstetrics and Gynecology
Laboratory: Mahendroo Laboratory
mala.mahendroo@utsouthwestern.edu

Research: My research interests include an understanding of the molecular mechanisms by which the cervix remodels during pregnancy, parturition and postpartum to allow birth and subsequent recovery of the cervix to the nonpregnant state. Our focus is on understanding the contribution of the extracellular matrix, immune cells, and cervical cells to this process and their regulation during all phases of cervical remodeling.

Yunsun Nam, Ph.D.
Obstetrics and Gynecology
Laboratory: Nam Lab
yunsun.nam@utsouthwestern.edu

Research: Mechanisms of non-coding RNAs and their role in gene regulation important for development and cancer. A major focus is the molecular mechanism and regulation of microRNA processing. The long-term goal is not only to elucidate how ncRNAs work but also to identify new avenues for developing therapeutics.

Ann Word, M.D.
Obstetrics and Gynecology
Laboratory: Word Laboratory
ann.word@utsouthwestern.edu

Research: Mechanisms of extracellular matrix remodeling of the female reproductive tract in both physiologic states (e.g., during pregnancy, parturition, and the puerperium) and pathologic conditions (pelvic organ prolapse, urinary incontinence, and injury of the external anal sphincter). 


Affiliated Members

Bruce Carr, M.D.
Division of REI/Department of Obstetrics and Gynecology
bruce.carr@utsouthwestern.edu

Research: Regulation of Steroidogensis in the ovary, adrenal, and placenta. Specifically, the regulation of CYP 17 expression. In addition, conducting clinical trials of women with endometriosis, uterine leiomyoma, infertility, and fertility control.

Diego Castrillon, M.D., Ph.D.
Pathology
diego.castrillon@utsouthwestern.edu

Research: The Castrillon laboratory has broad interests in the intersection of reproduction, infertility, and cancer. Areas of special interest include P13K/Foxo signaling in the control and preservation of the gemline and the role of the LKB1/MTOR pathway in diverse cancers of the reproductive tract.

Cheng-Ming Chiang, Ph.D.
Cancer Center/Pathology
Laboratory: Chiang Laboratory
cheng-ming.chiang@utsouthwestern.edu

Research: Epigenetic control of gene regulation, mechanisms of transcriptional regulation in mammalian cells and in human papillomaviruses, and posttranslational modification of protein function.

Joel Elmquist, D.V.M., Ph.D.
Internal Medicine/Hypothalamic Research
Laboratory: Elmquist Lab
joel.elmquist@utsouthwestern.edu

Research: Dr. Elmquist's research focuses on identifying the pathways in the brain regulating body weight and glucose homeostasis. Toward these goals, Dr. Elmquist and colleagues have developed several mouse models that allow specific manipulation of key genes regulating energy balance and glucose homeostasis.

Taekyung Kim, Ph.D.
Neuroscience
Laboratory: Kim Lab
joel.elmquist@utsouthwestern.edu

Research: Dr. Kim's research focuses studying how neuronal activity controls gene expression in neurons to mediate synapse remodeling and plasticity.

Ralf Kittler, Ph.D.
Eugene McDermott Center for Growth and Development
Laboratory: Kittler Lab
ralf.kittler@utsouthwestern.edu

Research: Cancer genomics. The Kittler lab is studying cancer-specific genetic programs, which are key for the development of new diagnostic, prognostic, and therapeutic strategies. We combine analyses of the genomic binding sites (ChIP-Seq) of cancer-relevant transcription factors, epigenetic, gene expression, and clinical outcome data to make specific predictions about the role of transcription factors and functional interaction of multiple transcription factors in the regulation of cancer-relevant gene networks. 

David Mangelsdorf, Ph.D.
Pharmacology
Laboratory: Mangelsdorf-Kliewer Lab
davo.mango@utsouthwestern.edu

Research: The Mangelsdorf/Kliewer lab studies nuclear receptor regulation of metabolism and cancer. Recent studies have elucidated two endocrine signaling pathways mediated by fibroblast growth factors that govern fasting and feeding.

Carole Mendelson, Ph.D.
Biochemistry, Obstetrics and Gynecology
Laboratory: Mendelson Laboratory
carole.mendelson@utsouthwestern.edu

Research: Genetic and epigenetic mechanisms that mediate expression of specific genes in a tissue- and cell-specific manner, that activate gene expression at distinct phases of embryonic development, and modulate their expression by hormones and second messengers. 

Eric Olson, Ph.D.
Molecular Biology
Laboratory: Olson Lab
eric.olson@utsouthwestern.edu

Research: Our lab studies muscle cells as a model for understanding how embryonic cells adopt specific fates, and how programs of cell differentiation and morphogenesis are controlled during development. We have focused on discovering novel transcription factors and extracellular signals, as well as novel transcription factors that control development of these muscle cell types and remodeling in response to cardiovascular and neuromuscular diseases.

Charles Rosenfeld, M.D.
Pediatrics, Obstetrics and Gynecology, Anesthesiology
charles.rosenfeld@utsouthwestern.edu

Research: My lab is interested in establishing the mechanisms that contribute to the regulation of uteroplacental and fetal umbilical blood flows during pregnancy, in particular estrogens, K channels, and angiotensin II, and how they are modified in disease states such as maternal hypertension and diabetes. We are also interested in understanding vascular smooth muscle development, how that contributes to prenatal and postnatal blood pressure regulation, and how alterations in fetal growth and development alter subsequent blood pressure regulation in infancy, childhood, and the adult.

Philip Shaul, M.D.
Pediatrics
Laboratory: Shaul-Mineo-Umetani Lab
philip.shaul@utsouthwestern.edu

Research: Our lab is primarily engaged in endothelial cell biology. Our overall goal is to identify the molecular components, the protein-protein interactions, the regulatory events occurring within signaling modules on the plasma membrane which dictate endothelial cell phenotype, and the propensity for vascular disease. Investigations are performed in cell culture models and in both in vitro and in vivo reconstitution systems in genetically modified mice.

Clifford Wai, M.D.
Division of Urogynecology, Department of Obstetrics and Gynecology
Laboratory: Wai Laboratory
clifford.wai@utsouthwestern.edu

Research: Animal models for lower urinary tract dysfunction and anal incontinence. More recently, interests have included exploring the role of mechanical trauma, denervation, pregnancy, and the effects of growth factors and myogenic stem cells on wound healing of the external anal sphincter. Other research interests include urogynecology education, functional anatomy and biomechanics of gynecologic surgical procedures, patient outcomes in incontinence, and pelvic organ prolapse.

Yihong Wan, Ph.D.
Pharmacology
Laboratory: Laboratory of Yihong Wan
yihong.wan@utsouthwestern.edu

Research: Our long-term goal is to understand how the nuclear receptor family of transcription factors and associated pathways regulate development, metabolism, and cancer, using the skeleton and the mammary gland as model systems. 

Jiang Wu, Ph.D.
Physiology
Laboratory: Jiang Wu Lab
jiang9.wu@utsouthwestern.edu

Research: We are interested in chromatin regulation of signaling pathways that are important for stem cell self-renewal and differentiation. The current focus is the function of ATP-dependent chromatin remodeling complexes in embryonic and neural development.

Jian Xu, Ph.D.
Children's Medical Center Research Institute at UTSW
Laboratory: Jian Xu Lab
jiang9.wu@utsouthwestern.edu

Research: We are interested in chromatin regulation of signaling pathways that are important for stem cell self-renewal and differentiation. The current focus is the function of ATP-dependent chromatin remodeling complexes in embryonic and neural development. 

Andrew Zinn, M.D., Ph.D.
Internal Medicine/Eugene McDermott Center for Growth and Development
Laboratory: Zinn Laboratory
andrew.zinn@utsouthwestern.edu

Research: Genetic disorders of human growth, development, and reproduction, with emphasis on obesity and sex chromosome abnormalities.