Research in Biochemistry

Biochemistry at UT Southwestern Medical Center represents a rich variety of diverse disciplines ranging from chemical synthesis and metabolism to structural biology and disease states. Research within the Department of Biochemistry is pursued along three major areas: biochemistry/molecular biology, biophysics and chemistry. A major thread of chemistry links and binds our faculty together within this Department.

Chemical Investigation

Natural Product Isolation and Synthesis

Chuo Chen, Ph.D.
Associate Professor

Jef DeBrabander, Ph.D.
Professor

John MacMillan, Ph.D.
Assistant Professor

Uttam Tambar, Ph.D.
Assistant Professor

Organometallic and Medicinal Chemistry

J. Russell Falck, Ph.D.
Professor

Total Synthesis of Complex Molecules

László Kürti, Ph.D.
Assistant Professor

Joseph Ready, Ph.D.
Associate Professor

Metabolic Research

Amino and Ketoacid Metabolism

David Te-Chao Chuang, Ph.D.
Professor

Richard Max Wynn, Ph.D.
Associate Professor

P450 Metabolism

Ronald Estabrook, Ph.D.
Professor Emeritus

Biology of Glycoconjugates

Jennifer J Kohler, Ph.D.
Assistant Professor

Lipids and Nuclear Hormones

David Mangelsdorf, Ph.D.
Professor

Metabolites of Both Simple and Complex Carbohydrates

Benjamin Tu, Ph.D.
Assistant Professor

Kosaku Uyeda, Ph.D.
Professor

High-Throughput Screening and Small-Molecule Studies

Small-Molecule Isolation and Mechanisms of Action

Michael Roth, Ph.D.
Professor

Bruce Posner, Ph.D.
Associate Professor

Noelle Williams, Ph.D.
Associate Professor

Structure and Function Studies

X-ray Crystallography

Dominika Borek, Ph.D.
Assistant Professor

Chad Brautigam, Ph.D.
Assistant Professor

Johann Deisenhofer, Ph.D.
Professor

Elizabeth Goldsmith, Ph.D.
Professor

Zbyszek Otwinowski, Ph.D.
Professor

Luke Rice, Ph.D.
Assistant Professor

Daniel Rosenbaum, Ph.D.
Assistant Professor

Diana Tomchick, Ph.D.
Professor

Hong Zhang, Ph.D.
Associate Professor

Xuewu Zhang, Ph.D.
Assistant Professor

NMR Structural Analysis

Kevin Gardner, Ph.D.
Professor

Jose Rizo-Rey, Ph.D.
Professor

Michael Rosen, Ph.D.
Professor

Computational Biology

Nick Grishin, Ph.D.
Professor

Molecular Biology/Biochemistry

Gene Regulation

Richard Bruick, Ph.D.
Associate Professor

Cheng-Ming Chiang, Ph.D.
Professor

Masato Kato, Ph.D.
Assistant Professor

Steven McKnight, Ph.D.
Professor

Carole Mendelson, Ph.D.
Professor

Functions for RNA and Nucleic Acids

David Reid Corey, Ph.D.
Professor

Qinghua Liu, Ph.D.
Associate Professor

Signaling Mechanisms

Marie-Alda Gilles-Gonzalez, Ph.D.
Associate Professor

Kim Orth, Ph.D.
Professor

Vanessa Sperandio, Ph.D.
Professor

Disease States Studies

The Role of Oncogenes in Producing Cancer

Robert Hammer, Ph.D.
Professor

Molecular Engineering of Photonic Probes

Wen-Hong Li, Ph.D.
Associate Professor

Peptidomimetics

Gomika Udugamasooriya, Ph.D.
Assistant Professor