Research in Biochemistry

Biochemistry at UT Southwestern represents a rich variety of diverse disciplines ranging from chemical synthesis and metabolism to structural biology and disease states. Research within the Department of Biochemistry is pursued along three major areas: biochemistry/molecular biology, biophysics and chemistry. A major thread of chemistry links and binds our faculty together within this Department.

Chemical Investigation

Natural Product Isolation and Synthesis

Faculty
Chuo Chen, PhD
Associate Professor
Jef DeBrabander, PhD
Professor
John MacMillan, PhD
Assistant Professor
Uttam Tambar, PhD
Assistant Professor

Organometallic and Medicinal Chemistry

Faculty
J. Russell Falck, PhD
Professor

Total Synthesis of Complex Molecules

Faculty
László Kürti, PhD
Assistant Professor
Joseph Ready, PhD
Associate Professor

Metabolic Research

Amino and Ketoacid Metabolism

Faculty
David Te-Chao Chuang, PhD
Professor
Richard Max Wynn, PhD
Associate Professor

P450 Metabolism

Faculty
Ronald Estabrook, PhD
Professor Emeritus

Biology of Glycoconjugates

Faculty
Jennifer J Kohler, PhD
Assistant Professor

Lipids and Nuclear Hormones

Faculty
David Mangelsdorf, PhD
Professor

Metabolites of Both Simple and Complex Carbohydrates

Faculty
Benjamin Tu, PhD
Assistant Professor
Kosaku Uyeda, PhD
Professor

High-Throughput Screening and Small-Molecule Studies

Small-Molecule Isolation and Mechanisms of Action

Faculty
Michael Roth, PhD
Professor
Bruce Posner, PhD
Associate Professor
Noelle Williams, PhD
Associate Professor

Structure and Function Studies

X-ray Crystallography

Faculty
Dominika Borek, PhD
Assistant Professor
Chad Brautigam, PhD
Assistant Professor
Johann Deisenhofer, PhD
Professor
Elizabeth Goldsmith, PhD
Professor
Zbyszek Otwinowski, PhD
Professor
Luke Rice, PhD
Assistant Professor
Daniel Rosenbaum, PhD
Assistant Professor
Diana Tomchick, PhD
Professor
Hong Zhang, PhD
Associate Professor
Xuewu Zhang, PhD
Assistant Professor

NMR Structural Analysis

Faculty
Kevin Gardner, PhD
Professor
Jose Rizo-Rey, PhD
Professor
Michael Rosen, PhD
Professor

Computational Biology

Faculty
Nick Grishin, PhD
Professor

Molecular Biology/Biochemistry

Gene Regulation

Faculty
Richard Bruick, PhD
Associate Professor
Cheng-Ming Chiang, PhD
Professor
Masato Kato, PhD
Assistant Professor
Steven McKnight, PhD
Professor
Carole Mendelson, PhD
Professor

Functions for RNA and Nucleic Acids

Faculty
David Reid Corey, PhD
Professor
Qinghua Liu, PhD
Associate Professor

Signaling Mechanisms

Faculty
Marie-Alda Gilles-Gonzalez, PhD
Associate Professor
Kim Orth, PhD
Professor
Vanessa Sperandio, PhD
Professor

Disease States Studies

The Role of Oncogenes in Producing Cancer

Faculty
Robert Hammer, PhD
Professor

How Small Molecules Affect Neuropsychiatric Diseases

Faculty
Andrew A. Pieper, MD, PhD

Molecular Engineering of Photonic Probes

Faculty
Wen-Hong Li, PhD
Associate Professor

Peptidomimetics

Faculty
Gomika Udugamasooriya, PhD
Assistant Professor