Positron Emission Tomography
Positron emission tomography (PET) research in this laboratory includes:
- Design, synthesis, and in vivo evaluation of hybrid agents for PET/CT or PET/MRI dual-modality imaging of cancer and diabetes
- Design and synthesis of biocompatible nanosized scaffolds for multivalent presentation of functionalities for detection and intervention of disease states
The research interests of this group involve developing novel molecular imaging probes for the early detection of biological abnormalities and the efficacy evaluation of disease treatments.
The research involves multidisciplinary collaborations to identify and modify functional molecules or substrates for specific disease targets and modify them with radioisotopes, enabling them to be used in PET imaging while maintaining the desired biological activity. The radioisotopes emit positrons that annihilate with electrons to produce a pair of 511 keV photons, called gamma photons, for in vivo noninvasive detection and investigation of diseases via small animal nuclear imaging.