49th Annual Medical Student Research Forum
Sandeep Mehta, MS1
“AMPK Suppresses Autophagy in Redox-Stressed Cardiomyocytes”
Suzette Toombs, MS 2
“Prospective Validation of Prognostic Biomarker Panel for Bladder Cancer Management at Time of Transurethral Resection”
Jia Wang, MS 2
“Perioperative Continuation versus Interruption of Oral Hypoglycemic Agents in Type 2 Diabetic Patients Undergoing Ambulatory Surgery”
Viswatej Avutu, MS 1
“Peptide H2009.1 Uptake by αvβ6 in Non-Small Cell Lung Cancer Cells”
Nikhil Narang, Doris Duke Clinical Research Fellow
“Substantial Error in Estimation versus Measurement of Oxygen Consumption: Implications for Clinical Hemodynamic Assessment”
Jacob Grange, MS 2
“Regulation of Urine Calcium by Acid-Base and Magnesium”
Kathryn Bowman, MS 2
“Boosting of HIV-Specific CTL Responses Following Therapeutic Vaccination of HIV-Infected Individuals”
Jay Coleman, MS 1
“Myocyte Autophagy is Maladaptive in Doxorubicin-induced Cardiotoxicity”
48th Annual Medical Student Research Forum
"Factors Influencing Re-Excision Rates In Breast Conserving Surgery for Cancer"
Alison Unzeitig, MS2
Mentors: D Euhus, AM Leitch, J Huth, V Andrews, A Moldrem, R Rao
"Autophagic Activation and Loss of Mitochondrial Content during Mechanical Unloading-Induced Cardiac Atrophy"
Bennett Waxse, MS2
Mentors: Andrew Blagg and Joseph Hill, Department of Internal Medicine
"Hypoglycemia (H) in the Late-Preterm Neonate (LPN)"
Roselynn Nguyen, MS2
Mentors: S. Raff, M.D. Manning, W.D. Engle, G.L. Jackson
"Burden of Medical Radiation Exposure in Children with Sickle Cell Disease"
Courtney L. Wendel, MS2
Mentors: John A. Anderson, Timothy J. Blackburn, and Charles T. Quinn, Center for Cancer and Blood Disorders, Departments of Radiology and Pediatrics
"Effects of Reduced Transcription Rate on hTERT Alternative Splicing"
Radhika Kainthla, MS2
Mentor: Woodring Wright, Department of Cell Biology
"Reliable Quantification of Daily Cardiac Work for Long Duration Spaceflight"
David Liang, MS2
Mentor: Benjamin Levine; IEEM-Presbyterian Hospital
"Combining SMAC Mimetic Targeted Therapy with Gefitinib or Doxorubicin Demonstrates Dramatic Differences in Non-Small Cell Lung Cancer Drug Response Phenotypes"
Leila Zuo, MS1
Mentors: John Minna, Hamon Center for Therapeutic Oncology
"Stroke Volume during Exercise is associated with Insulin Sensitivity among Women with Polycystic Ovarian Syndrome"
Juhee Choi, MS1
Mentors: Peter Snell, M. Dean Palmer, Benjamin D. Levine, Alice Y. Chang, Department of Internal Medicine
"Clinical Spectrum of Disease Associated with Telomerase (TERT) Mutations"
Alberto Diaz de Leon, Doris Duke Clinical Research Fellow
Mentor: Christine Garcia, Division of Pulmonary and Critical Care
"Why Are So Many Eligible Children Still Uninsured? The Perspectives of Parents of Uninsured African-American Children"
David Leverenz, MS1
Mentor: Glenn Flores, General Pediatrics
"Multifunctional pH Responsive Polymer Micelles for Therapeutic and Diagnostic Cancer Nanomedicine"
Jason Liu, MS2
Mentors: Jinming Gao, Associate Professor, Simmons Comprehensive Cancer Center
"Genotype G Hepatitis B Virus (HBV) and Advanced Liver Fibrosis in HIV/HBV Co-Infected Patients"
Doan Y Dao, MS2
Mentors: Jody Balko, Nahid Attar, He-Jun Yuan, William M. Lee, Mamta K. Jain. Department of Internal Medicine
47th Annual Medical Student Research Forum
Saiqa Khan, MS 2
Mentors: Ian Mitchell and Fiemu Nwariaku, Department of Surgery
"Response of Anaplastic Thyroid Tumors to VEGF-Trap, an Anti-Angiogenic Agent"
Heather Copeland Hummel, MS2
Mentors: Dian Cao and Joseph Hill, Division of Cardiology
"HDAC Inhibition and Autophagy in in vitro Cardiomyocyte Hypertrophy"
Jerry P. Kalangara, MS 3
Mentors: Danielle Robertson and H. Dwight Cavanagh, Department of Ophthalmology
"Tissue Engineered Universal Artificial Corneal Epithelium"
Juanita Garces, MS 2
Mentors: Ramon Diaz-Arrastia, and Carlos Marquez de la Plata, Department of Neurology, UT Southwestern, and Center for Brain Health, UT Dallas
"Resting State Functional MRI in Traumatic Brain Injury Reveals Deficits in Connectivity of Limbic and Frontal Circuits"
Premal Bhavsar, MS 1
Mentors: Christopher J. Madden and Ramon Diaz-Arrastia,
"Observational Cohort Study of the Impact of Anemia and Transfusion on Outcome after Traumatic Brain Injury"
Doan Dao, NIDDK Medical Student Research Trainee Award Recipient,
Mentors: R. Ann Word and William M. Lee, Dept. of Internal Medicine.
"Host Responses and Virologic Profiles in Patients with Acute Liver Failure Secondary to Acute Hepatitis B Virus Infection (HBV) or Acute Exacerbation on Chronic HBV"
Shinjita Das, MS 2, Mentors: Andrew Blagg and Joseph Hill, Division of Cardiology
"Autophagic Processing of Polyubiquitinated Protein Aggregates During Unloading-Induced Cardiac Atrophy"
46th Annual Medical Student Research Forum
The speaker at the 46th Annual Forum was Errol Crook, MD, Chairman of the Internal Medicine Department at the University of Southern Alabama. The title of his talk was "Why Medical Research Is More Important Than Ever". A reception and poster session followed the Forum in the Faculty Club. Student co-chairs for the event were Blake Gregory, MS2 and Meghan McDonald, MS2.
Timothy Brown, MS1
Mentors: Ian Mitchell, Fiemu Nwariaku, Dept. of Surgery
"Development of an In-Vivo Zebrafish Model for Knockdown of Vascular Endothelial Cadherin"
Dhriti Mukhopadhyay, MS2
Mentors: Hongyu Wang, Shuxin Li, Dept. of Neurology
"Promoting Myelination with RhoA-inhibiting NSAIDs in the CNS"
Dhruti M. Patel, Doris Duke Fellow
Mentors: Lalitha Subramanyam, Claudia Quittner, Vinaya Simha, Dolores Peterson, Abhimanyu Garg, Dept. of Internal Medicine
"Longitudinal Assessment of Lipodystrophy in Naïve HIV-infected Patients Randomized to a protease inhibitor (PI)-based or an nonnucleoside reverse transcriptase Inhibitor (NNRTI)-based antiretroviral regimen"
Rohit Sharda, MS2
Mentors: Samuel D. Luber; Lynn Roppolo, Ahamed Idris, Dept. of Surgery
"Blood Pressure Response to the Impedance Threshold Device in Hypotensive Emergency Department Patients"
Blake Gregory, MS2
Mentors: Clarita Odvina, Orson Moe, Joseph Zerwekh, Khashayar Sakhaee, William M. Lee, Dept. of Internal Medicine
"Abnormal Urinary Excretion of Phosphate is Responsible for Hypophosphatemia in Acute Liver Failure"
Anh Nguyen, MS2
Mentors: Ahamed Idris, Chris Madden, Karla Saner, Jane G. Wigginton, D/FW Center for Resuscitation Research, Department of Neurosurgery
"Sex Steroid Level Alterations in the Blood and CSF Following Severe Traumatic Brain Injury"
Justin Chen, MS2
Mentors: Jay D. Horton, Depts. of Internal Medicine / Molecular Genetics
"Inhibition of PSCK9 mediated destruction of hepatic LDL receptor by blocking their interaction at the cell surface"
Rebecca Adelagun, MS2
Mentors: Xiaoyun Liu, Laurentiu Pop, Ellen Vitetta, Cancer Immunobiology Center.
"The Generation and Evaluation of Immunotoxins Prepared With Chimeric, Monoclonal Antibodies Containing Mutations in Their Fc Portions"
45th Annual Medical Student Research Forum
The speaker at the 45th Annual Forum that was held on January 16, 2007, was Joan H. Schiller, MD, Chief, Division of Hematology and Oncology, Deputy Director of the Simmons Comprehensive Cancer Center. The title of her talk was "A Career in Academic Medicine: Pros and Cons". Student co-chairs were Jarrod Dale and Daniel Yang.
Myda Luu, MS2
Mentor: Dr. Thomas Anthony
“Surgical Site Infections in Patients Undergoing Colorectal Surgery”
Matthew Eng, MS2
Mentor: Dr. Paul F. White
“Effect of Short-Term Postoperative Celecoxib Administration on Patient Outcomes after Outpatient Laparoscopic Surgery”
Justin Grodin, MS2
Mentor: Ellen Vitetta
“A New Multidrug Resistant (MDR) Human B-lymphoma Cell Line (R18V) was Generated by Drug Selection to Stably Express P-glycoprotein (P-gp)”
Shahed Shakouri, MS2
Mentor: Dr. Mamta Jain
“Factors Associated with Death in HIV-Infected Persons: A Six Year Survival Analysis”
Nikki Garg, MS2, Tanzim Ludhi, MS2
Mentor: Dr. Ildiko Lingvay
“The Effect of Treatment of Type 2 Diabetes on Hepatic Steatosis”
Swalpa Udit, MS1
Mentor: Dr. Osamu Nakagawa
“Regulation of MEF2-Dependent Transcription by the HRT Family of Transcriptional Repressors in the Heart”
Blake Gregory, MS1
Mentor: Dr. William M. Lee
“Reliability of Acetaminophen Dosing Information in ACM-Induced Acute”
Karen Chen, MS2
Mentor: Dr. Darren McGuire
“Independent and Additive Influence of Metabolic Syndrome and Diabetes Mellitus on Atherosclerosis: Observations from the Dallas Heart Study”
Meghan McDonald, MS1
Mentor: Dr. Helen Hobbs
“PCSK9 and LDLR Trafficking in Hepatocytes”
44th Annual Medical Student Research Forum
The guest speaker at the 44th Annual Medical Student Research Forum was Dr. Beth Levine, M.D., Professor of Internal Medicine and Microbiology, Chief, Division of Infectious Diseases. Her topic was "A Cellular Garbage Disposal System and Human Disease”. Student co-chairs were Mariam Orji and Daniel Sherbet.
Mentor: Paul F. White
"Preemptive Analgesic Efficacy of Oral Celecoxib (Celebrex®) in Patients Undergoing Major Plastic Surgery Procedures"
Mentors: Joseph Goldstein and Michael Brown
"Purification and Characterization of Membrane-Bound Oxysterol Binding Protein (MOBP)"
Mentors: Mark A. Valasek, R. H. Unger, and Joyce J. Repa
"The Vitamin D Receptor does not regulate leptin receptor expression during adipocyte differentiation, although 1,25-dihydroxyvitamin D blocks adipogenesis"
Mentors: Hiroshi Noto and Philip Raskin
"The Role of Platelet Activating Factor Acetylhydrolase (PAF-AH) in the Metabolic Syndrome in Diabetic Patients"
Mentors: Jonathan Cohen and Helen Hobbs
"Sequence Variations in Protein Convertase Subtilisin/Kexin 9"
Mentors: Joseph Goldstein and Michael Brown
"Varying levels of Insig-1 after feedback regulation of SREBP processing"
Mentor: Connie C.W. Hsia
"Impairment of Pulmonary Function in Patients with Diabetes Mellitus"
Mentors: Daniel B. Hardy and Carole R. Mendelson
"Developmental Regulation of the Eicosanoid Pathway Mediates the Induction of Surfactant Protein A (SP-A) Expression in the Fetal Lung"
Mentors: Helen Hobbs and Jonathan Cohen
"Novel genetic defect that causes extreme responsiveness to dietary cholesterol"
43rd Annual Medical School Research Forum
Mariam Orji, MS1, "Phosphoinositide - 3 Kinase Pathway Inhibition Reduces Hypoxia- Induced VEGF Secretion In Follicular Thyroid Cancer"
Benjamin Hatten, MS3, "A Prospective Study Comparing Standard Laryngoscopy to the Trachview Videoscope System For Orotracheal Intubation by Emergency Medicine Residents and Medical Students"
Jill Vilaythong, MS2, "Identification of Proteins that interact with the AR Coactivator Protein, ARA70"
Christina Robinson, MS1, "Infarct Artery Patency and Prior Treatment with Beta-Blockers, Aspirin, Statins, and ACE-Inhibitors"
Agnes Wang, "Saturation Prostate Biopsies after Negative Office-based TRUS Biopsies: Analyses of Outcome Predictors"
Sarah Guinn, MS2, "Targeting Multiple Her-2 Epitopes with IgG or F(ab)'2 Fragments of anti-Her-2 monoclonal antibodies (M Abs) to induce Anti-growth Activity of BT474 Human Breast Cancer Cells"
Sandra Saldaña, Doris Duke Medical Student Research Fellow, "Are Serial Liver Biopsies Useful in Individuals with Primary Biliary Cirrhosis"?
Daniel Sherbet, HHMI Medical Student Researcher, "Structural determinants of 17 beta-hydroxysteroid dehydrogenase directionality"
42nd Annual Medical Student Research Forum
William R. Keller, MS II, " AD Subjects Have Quantitatively Greater Leukoariosis than Normal Controls"
Monisha Dandekar, MS II, " Quantification of Neural Precursor Cells in the Hippocampus of Young and Adult Mice using FACS analysis on GFP Expressing Transgenic Mice"
Shilpa R. Miniyar, MS II, "Depo-Provera ® and Herpes Genitalis: Is There an Association?"
Kelly Kovaric, MS I, "Changes in Expression and Modification of the Progesterone Receptor (PR) in Human Myometrium and Mouse Uterus at Term May Contribute to the Initiation of Labor"
Erica P. Ruger, MS II, "Can a Barbershop-Based Intervention Change the Health Beliefs and Behaviors that Impact Awareness, Treatment and Control of Hypertension in African-American Men?"
Bryan Ong, MS II, "Liver X Receptors: A Novel Role in Androgenetic Alopecia"
Fatema Uddin, MS II, "Ethnicity and Heart Failure (HF) Outcomes: Experience from a Dedicated HF Clinic in an Urban Public Hospital"
Michelle C. Crank, MS II, "Mechanisms Underlying the Reversal of Multidrug Resistance (MDR) in Human B-Cell Lymphoma by the Anti-CD20 Monoclonal Antibody (Mab), Rituximab (RTX)"
41st Annual Medical Student Research Forum
Joy Falola, “Anti-Proliferative Effects of SRC Inhibition on MAPK Activity and Proliferation of Medullary Thyroid Cancer ”
Jeremiah Seely, “Transcriptional Regulation of Dihydroepiandrosterone Sulfotransferase (SULT2A1) by Estrogen-Related Receptor alpha (ERRalpha)”
Lyndsey Cox, “Comparative Study of COX-2 Inhibitors in Preventing Pain After Ambulatory Surgery”
Geoff Elmore, “Exogenous Retinoic Acid Enhances Strain-induced Lung Growth Following Pneumonectomy”
Danika Taylor, “Cloning of a Novel Isoform of 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) from Human Liver”
Agnes Wang, “Effect of AEP Monitoring on Intraoperative Drug Use and Recovery After Inpatient Surgical Procedures: A Clinical Utility Study”
J. Wade Wilson, “The Induction of Progesterone Metabolizing Enzymes in Human Myometrium at Term May Contribute to the Initiation of Labor”
Jennifer York, “LXR-agonist Associated Increase in Biliary Cholesterol Secretion Requires ATP Binding Cassette Transporters ABCG5 and ABCG8”
40th Annual Medical Student Research Forum
Patricia Jimenez, MS 1, “Transcriptional regulation of 3beta-hydroxysteroid dehydrogenase type II (3beta-HSD) by the transcription factor NGFI-B”
Travis Brown, MS 1, “HIV-1 Coreceptor Expression and Cutaneous Immune Response to Treponema pallidum”
Gregory Moses, MS 1, “Hepatitis C Virus NS5A Protein Inhibits The PKR Mediated Cellular Antiviral Response During Viral RNA Replication In Human Liver Cell Lines”
Matthew Stair, MS 2, “Differential Sensitivities of the Xenopus Androgen Receptor and the Human Androgen Receptor”
Ahmed Shakir, MS 1, “Lung Nitric Oxide Production is Impaired in Sarcoidosis”
Neil Patel, MS 2, “Evidence for interaction between clathrin and ARH, the protein defective in autosomal recessive hypercholesterolemia”
Mark Valasek, MS 1, “Mast Cell Degranulating Dodecapeptide from Rana rugosa, Granuliberin-R, Specifically Activates a Human Orphan G Protein-Coupled Receptor”
Daniel Sherbet, MS 1, “Mutation E305G In The Active Site Of CYP17 Causes Isolated 17, 20-Lyase Deficiency By A Novel Mechanism”
39th Annual Medical Student Research Forum
Joseph Berger, MS 1, "Serum Autoantibodies Against Adipocyte Proteins In Acquired Generalized Lipodystrophy"
Cecilia Garcia, MS 3, "A New Expandable Bioresorbable Polymeric Ureteral Stent"
Chad Hanson, , MS 1, "Sarcoidosis Reduces Pulmonary Diffusing Capacity By Destroying Capillaries"
Alan Lam, MS 2, "Iliac Apophysis Allografts In Rabbit Distal Femoral Growth Plates"
Zhi Mao, MS 1, and Jason Jones, MS 1, "Enhancement Of Alloproliferative Responses By CD27 - CD27L (CD70) Interactions"
Rashmi Mullur, MS 1, "Elucidation Of The Mechanism By Which (+) - Acylcarnitines Inhibit Mitochondrial Fatty Acid Oxidation"
Ross Thormahlen, MS 1, "The Oncogene EWS/FLI-1 Interacts With The Transcriptional Coactivators P300/CBP and Alters The Differentiation Program Of The Multipotential Cell LineC2C12"
Su Yin, MS 1, "Gene Profiling Of Pregnant and Non-pregnant Myometrium"
38th Annual Medical Student Research Forum
Preetpaul Bajwa (MSI) "Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice" (Mentor: Dr. Laurence Tecott).
Antonia M. Davidson (MSII) "Palmitoylation in the Regulation of Cellular G Protein Levels" (Mentor: Dr. Susanne Mumby).
Warren L. Dinges, Ph.D. (MSII) "Magnetic Resonance Imaging (MRI) of Lipodystrophy in HIV-Infected patients (LDHIV)" (Mentor: Dr. Dolores Peterson).
Christina A. Dooley (MSIII ) "Bone Morphogenetic Protein Inhibits Ovarian Androgen Production" (Mentor: Drs. Bruce Carr and William Rainey).
Rajul Jain (MSIII) "Elucidating Relationships between Structure and Energy in Proteins" (Mentor: Dr. Rama Ranganathan).
Daniel J. Kim (MSII) "The Bone-Implant Interface in Ream and Unreamed Uncemented Femoral Implants" (Mentor: Drs. Maureen Finnegan and F. Gottschalk).
Aimee Seungdamrong (MSIV) "Xenogenic Co-cultures of Rat Spermatogenic Cells with a Blasticidin S-Resistant Mouse Sertoli Cell Line: MSC-KL Cells" (Mentor: Dr. David Garbers).
Jing Shen (MSII ) "Kinase Regulation of the NF-KB Pathway" (Mentor: Dr. Richard Gaynor).
1999 Medical Student Research Forum
Interleukin 1 Regulates Surfactant Protein A Gene Expression in Fetal Lung: Possible Role of Transcription Factor NF-KB, Amit R. Patel, Mentor: Carole R. Mendelson, Department of Biochemistry.
Angiogenesis and Antifolate Chemotherapy: A New Target For Old Drugs, Miriam C. White, Mentor: Barton Kamon, Pediatric Oncology and Pharmacology.
The Stone-Forming Risk of Calcium Consumption, Mark F. Doerner, Mentor: Howard J. Heller, Department of Internal Medicine.
Regulation of Steroidogenic Acute Regulatory (STAR) Protein Expression in Human Ovarian Theca-Like Tumor Cells, Christina A. Dooley, Mentor: Bruce R. Carr, OB/GYN
Mechanisms of HTLV-1 TAX Activation of the NF-KB Pathway, Kevin T. Palka, Mentor: Richard Gaynor, Departments of Internal Medicine and Microbiology.
Changes in Thymic Function with Age and During the Treatment of HIV Infection, Earl A. Gage, Mentor: Richard A. Koup, Departments of Internal Medicine and Microbiology.
Hyperspectral Imaging Microscopy: a Novel Method for Microscopic Analysis, Thomas Nielsen and Jeff Zavaleta, Mentor: Harold Garner, Departments of Biochemistry and Internal Medicine.
Targeting Axon Growth Along a Preformed Pathway from Transplanted Neurons to a Neurotrophic Source, Ajith Nair, Mentor: George M. Smith, Department of Anesthesiology.