Pharmacological Sciences Faculty
David Mangelsdorf, Ph.D.
Joseph Albanesi, Ph.D.
Research Interests: Mechanisms of membrane fusion; role of lipids in membrane trafficking; membrane vesiculation of dynamin
Steven Altschuler, Ph.D.
Research Interests: Single cell perturbation analysis of cell signaling pathways
Rolf A. Brekken, Ph.D.
Research Interests: Tumor-host interactions in pancreatic cancer
Yuh Min Chook, Ph.D.
Research Interests: Structures and mechanisms of nuclear transport and the nuclear pore complex
Melanie Cobb, Ph.D.
Research Interests: Protein kinase cascades; MAP kinases; signal-transduction mechanisms
David R. Corey, Ph.D.
Research Interests: Engineering proteins and nucleic acids for novel function
J. R. Falck, Ph.D.
Research Interests: Total synthesis of natural products; synthetic methodology; organometalics; eicosanoids; medicinal chemistry
Kevin H. Gardner, Ph.D.
Research Interests: NMR-based structural studies of proteins involved in transcriptional regulation
Alfred Gilman, MD, Ph.D.
Research Interests: Hormonal regulation of cyclic AMP metabolism; mechanisms of control of hormone-sensitive adenylate cyclase; regulatory GTP-binding proteins
Joel Goodman, Ph.D.
Research Interests: Intracellular sorting of newly synthesized proteins; organelle biogenesis and membrane structure and function; the yeast peroxisome as a model of organellar assembly
Jin Jiang, Ph.D.
Research Interests: Signal-transduction pathways in development and human disease; genetic control of organ growth and patterning; tumor suppressor genes
Jane E. Johnson, Ph.D.
Research Interests: Molecular biology of mammalian neural development
Steven Kliewer, Ph.D.
Research Interests: Physiology of nuclear receptors
Mark Lehrman, PhD
Research Interests: Informational carbohydrates in the endoplasmic reticulum: roles in protein folding, stress responses, and human disease
David Mangelsdorf, Ph.D.
Research Interests: Mechanism of nuclear hormone receptor action; role of retinoids in cancer; transcriptional regulation of lipid metabolism
John Minna, M.D.
Research Interests: Molecular genetics of human cancer; growth factors, and signal transduction in human tumors
Margaret Phillips, Ph.D.
Research Interests: Polyamine and pyrimidine metabolism in trypanosome and malaria parasites
Rama Ranganathan, M.D., Ph.D.
Research Interests: Structural basis for signal processing in Drosophila photoreceptors
Jose Rizo-Rey, Ph.D.
Research Interests: Structural analysis by nuclear magnetic resonance of proteins involved in calcium-triggered synaptic vesicle exocytosis
Michael Rosen, Ph.D.
Research Interests: Analysis of the structural, biochemical, and cell biological mechanisms that regulate the actin cytoskeleton
Elliott Ross, Ph.D.
Research Interests: Mechanisms and regulatory behavior of G-protein signaling; regulated protein-protein interactions in signal transduction
Dean Smith, M.D., Ph.D.
Research Interests: Sensory transduction in Drosophila melanogaster
Paul Sternweis, Ph.D.
Research Interests: Regulation of intracellular events by cell-surface receptors; structure and function of GTP-dependent regulatory proteins and their effectors
Ronald Taussig, Ph.D.
Research Interests: G protein-mediated signaling
Jonathan Terman, Ph.D.
Research Interests: Axonal growth and guidance; neuronal connectivity; axonal regeneration
Philip Thorpe, Ph.D.
Research Interests: Development of novel angiogenesis inhibitors and agents for inducing thrombosis of tumor blood vessels for cancer treatment
Thomas Wilkie, Ph.D.
Research Interests: Signal-transduction pathways in mammalian development and energy homeostasis
Lani Wu, Ph.D.
Altschuler and Wu Lab
Research Interests: Design principles in biological networks
Hongtao Yu, Ph.D.
Research Interests: Study of cell division cycle
Research Interests: Growth factor-mediated signal transduction in embryonic stem-cell biology, germ-cell fate determination and nuclear reprogramming
Yingming Zhao, Ph.D.
Research Interests: Functional proteomics and mass spectrometry