Computational and Systems Biology Faculty

Lindsay Cowell, Ph.D.
Associate Professor
Research Interests: Somatic diversification of antigen receptor genes; repertoire characteristics as biomarkers of immune status and disease; host-pathogen interactions


Gaudenz Danuser, Ph.D.
Professor
Research Interests: Mechanical and chemical signal integration in migration, survival, and drug response of the metastatic cell; computer vision, machine learning and mathematical modeling of complex signal transduction pathways; live cell imaging.


Nick Grishin, Ph.D.
Professor
Grishin Lab 
Research Interests: Computational biology; analysis of protein sequences and structures


Tae Hyun Hwang, Ph.D.
Assistant Professor
Hwang Lab 
Research InterestsBioinformatics, computational biology, network analysis, next generation sequencing analysis, machine learning, and big data analysis


Khuloud Jaqaman, Ph.D.
Assistant Professor
Jaqaman Lab
Research Interests: Quantitative spatiotemporal structure-function relationships of multi-molecular assemblies; linking molecular and cellular behavior across multiple scales; computational image analysis and mathematical modeling.


Steve Jiang, Ph.D.
Professor
Jiang Lab 
Research Interests: Dr. Jiang been working on the use of personal high performance computing device such as GPU to improve the efficiency and more importantly, to change the way we diagnose and treat patients in cancer radiotherapy. Particularly, he and his team have developed dozens of GPU tools allowing ultra-fast image registration and reconstruction, as well as real-time radiotherapy treatment optimization and planning. Currently, they are focused on the development of a GPU and cloud computing based next generation treatment planning system.


W. Lee Kraus, Ph.D.
Professor
Kraus Lab 
Research Interests: Computational genomics. Using molecular, genetic, genomic, and computational approaches to understanding signal-regulated gene expression. Integrating data from different genomic platforms using computational approaches.


Zbyszek Otwinowski, Ph.D.
Professor
Otwinowski Lab
Research Interests: Development of methods to study next generation sequencing and X-ray crystallographic data


Rama Ranganathan, M.D., Ph.D.
Professor
Ranganathan Lab
Research Interests: The evolutionary design of proteins and cellular signaling networks


Kimberly Reynolds, Ph.D.
Assistant Professor
Reynolds Lab
Research Interests: Statistical analysis and rational design of cellular systems


Luke Rice, Ph.D.
Assistant Professor
Rice Lab
Research Interests: Integrating structure, kinetics, and computation to understand the molecular determinants and regulatory mechanisms of microtubule dynamics


Elliott Ross, Ph.D.
Professor
Ross Lab
Research Interests: Cellular information processing; molecular mechanisms of G protein-mediated signaling:  amplification, selectivity, response kinetics  and signal integration  


Guanghua Xiao, Ph.D.
Associate Professor
Xiao Lab
Research Interests: Our lab focuses on improving treatments for cancer by applying computer science and statistical methodologies to analyzing high-throughput biological data. New models and tools are currently in development to assist the investigation of disease mechanisms and their related diagnostic innovations.


Yang Xie, Ph.D.
Associate Professor
Xie Lab
Research Interests: Biostatistics, bioinformatics, statistical genomics, clinical trial design, and biomarker studies.


Chao Xing, Ph.D.
Associate Professor
Xing Lab
Research Interests:  Statistical genetics, genetic epidemiology, bioinformatics, gene mapping for complex traits.


Xiaowei Zhan, Ph.D.
Assistant Professor
Research Interests: Statistical genetics, forward genetics screening, statistical computation, next-generation sequencing, genetic association studies


Associate Members

Dominika Borek, Ph.D.
Assistant Professor
Research Interests:  Development of methods to study heteroplasmy and the somatic evolution of cancers.


Gary Hon, Ph.D.
Assistant Professor
Research Interests: Integrating genomics and bioinformatics techniques to develop a comprehensive understanding of how the millions of non-coding regulatory elements encoded in our genomes precisely coordinate gene expression in developmental and disease contexts.


Julia Kozlitina, Ph.D.
Assistant Professor
Research Interests: Statistics, statistical genetics, genetic epidemiology, genome-wide association studies.


Steven Patrie, Ph.D.
Assistant Professor 
Patrie Lab
Research Interests: Analytical, informatics, and big data methods in proteomics


Junmei Wang, Ph.D.
Assistant Professor
Wang Lab
Research Interests: Molecular mechanical force field development; virtual screenings for drug lead identification; Molecular dynamics simulations of protein folding and drug delivery; and rational protein design